Search Results - "Helsen, Christopher"

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity by Helsen, Christopher W., Hammill, Joanne A., Lau, Vivian W. C., Mwawasi, Kenneth A., Afsahi, Arya, Bezverbnaya, Ksenia, Newhook, Lisa, Hayes, Danielle L., Aarts, Craig, Bojovic, Bojana, Denisova, Galina F., Kwiecien, Jacek M., Brain, Ian, Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.

“…Engineering T cells with chimeric antigen receptors (CARs) is an effective method for directing T cells to attack tumors, but may cause adverse side effects…”
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Insight into Molecular Basis of Curing of [PSI+] Prion by Overexpression of 104-kDa Heat Shock Protein (Hsp104) by Helsen, Christopher W., Glover, John R.

“…Yeast prions are a powerful model for understanding the dynamics of protein aggregation associated with a number of human neurodegenerative disorders. The AAA+…”
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Primary Structure Elements of Spider Dragline Silks and Their Contribution to Protein Solubility by Huemmerich, Daniel, Helsen, Christopher W, Quedzuweit, Susanne, Oschmann, Jan, Rudolph, Rainer, Scheibel, Thomas

“…Spider silk proteins have mainly been investigated with regard to their contribution to mechanical properties of the silk thread. However, little is known…”
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T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively target multiple myeloma by Bezverbnaya, Ksenia, Hammill, Joanne A., Cummings, Derek, Bojovic, Bojana, Groisman, Bella, Baker, Christopher L., Aarts, Craig, Hayes, Danielle L., Rill, Donna, Xu, Stacey X., Bader, Andreas G., Helsen, Christopher W., Bramson, Jonathan L.

“…B-cell maturation antigen (BCMA) is a clinically validated target for multiple myeloma. T-cell engineered with chimeric antigen receptors (CARs) directed…”
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Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes by Hammill, Joanne A, Afsahi, Arya, Bramson, Jonathan L, Helsen, Christopher W

“…The adoptive transfer of a bolus of tumor-specific T lymphocytes into cancer patients is a promising therapeutic strategy. In one approach, tumor specificity…”
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors by Hammill, Joanne A, VanSeggelen, Heather, Helsen, Christopher W, Denisova, Galina F, Evelegh, Carole, Tantalo, Daniela G M, Bassett, Jennifer D, Bramson, Jonathan L

“…Adoptive cell transfer of tumor-specific T lymphocytes (T cells) is proving to be an effective strategy for treating established tumors in cancer patients. One…”
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Tumor-targeting domains for chimeric antigen receptor T cells by Bezverbnaya, Ksenia, Mathews, Ashish, Sidhu, Jesse, Helsen, Christopher W, Bramson, Jonathan L

“…Immunotherapy with chimeric antigen receptor (CAR) T cells has been advancing steadily in clinical trials. Since the ability of engineered T cells to recognize…”
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A new perspective on Hsp104-mediated propagation and curing of the yeast prion [PSI+] by Helsen, Christopher W., Glover, John R.

“…Most prions in yeast form amyloid fibrils that must be severed by the protein disaggregase Hsp104 to be propagated and transmitted efficiently to newly formed…”
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118 Development of Claudin 18.2 TAC T cells for the treatment of gastric cancer by Helsen, Christopher, Benatar, Tania, Philbert, IP, Xu, Stacey, Shaver, Laura, Nitya-Nootan, Thanyashanthi, Bader, Andreas, Lal, Prabha

“…BackgroundThe T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the re-direction of T cells to tumor cells and activates…”
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The C-terminal Extension of Saccharomyces cerevisiae Hsp104 Plays a Role in Oligomer Assembly by Mackay, Ryder G., Helsen, Christopher W., Tkach, Johnny M., Glover, John R.

“…The Saccharomyces cerevisiae protein Hsp104, a member of the Hsp100/Clp AAA+ family of ATPases, and its orthologues in plants (Hsp101) and bacteria (ClpB)…”
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372 TAC-T cells persist and remain functional during and after repeated tumor exposure in vitro and in vivo by MacGregor, Heather L, Prosser, Suzanna L, Xu, Stacey X, MacDonald, Kyle, Kadri, Aksha, Randhawa, Ritu R, Shetty, Swati, Pirati, Sailaja, Bhemarasetty, Deepika, Helsen, Christopher W, Sengupta, Sadhak, Bader, Andreas G

“…BackgroundT cell antigen coupler (TAC) is a chimeric receptor that redirects T cells (TAC-T) towards surface-expressed tumor antigens to create safe and…”
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347 Functional characterization of GUCY2C-TAC T cells for the treatment of colorectal cancer using preclinical models by Benatar, Tania, Nitya-Nootan, Thanyashanthi, Thakor, Gargi, Prosser, Suzanna L, Ip, Philbert, Lal, Prabha, Khan, Alima, Xu, Stacey X, Pirati, Sailaja, Bhemarasetty, Deepika, Helsen, Christopher W, Bader, Andreas G

“…BackgroundThe T cell antigen coupler (TAC) is a novel chimeric receptor that facilitates the redirection of T cells to tumor cells and activates T cells by…”
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400 Preclinical characterization and modelling of allogeneic Vγ9Vδ2 TAC T cells for the treatment of solid tumors by Xu, Stacey X, Prosser, Suzanna L, Wang, Ling, Randhawa, Ritu R, Pirati, Sailaja, Bhemarasetty, Deepika, MacDonald, Kyle, Yoo, Seung Mi, Jung, Miyoung E, Gheorghiu, Laurentia A, Ayers, Chris L, Sengupta, Sadhak, Helsen, Christopher W, Bader, Andreas G

“…BackgroundThe T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the redirection of T cells to tumor cells and activates T…”
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Abstract 1424: Preclinical development of TAC01-CD19, a CD19 specific T-cell Antigen Coupler (TAC) therapy for the treatment of CD19-positive B cell malignancies by Helsen, Christopher W., Hayes, Danielle, Hammill, Joanne, Aarts, Criag, Bader, Andreas, Rill, Donna, Bramson, Jonathan

“…Background: The T cell antigen coupler (TAC) is a chimeric receptor co-opting the natural TCR receptor signaling complex to target tumor antigens in an…”
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T Cells Engineered with T Cell Antigen Coupler (TAC) Receptors for Haematological Malignancies by Helsen, Christopher, Lau, Vivian, Hammill, Joanne, Mwawasi, Kenneth, Hayes, Danielle, Afsahi, Arya, Bezverbnaya, Ksenia, Aarts, Craig, Denisova, Galina, Bramson, Jonathan

“…Background: We recently described the T cell antigen coupler (TAC) technology (Helsen et. al. Nature Communications) which is a chimeric receptor that targets…”
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T Cells Engineered with a Novel Chimeric Receptor Demonstrate Durable In Vivo Efficacy Against Disseminated Multiple Myeloma by Bezverbnaya, Ksenia, Lau, Vivian, Aarts, Craig, Denisova, Galina, Afsahi, Arya, Evelegh, Carole, Cummings, Derek, Helsen, Christopher, Bramson, Jonathan

“…▪ Despite recent therapeutic developments, multiple myeloma remains an incurable plasma cell malignancy. Poor prognosis for myeloma patients relapsing…”
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294 Preclinical studies of TAC01-CLDN18.2, an autologous claudin 18.2-directed TAC T cell therapy, in the treatment of gastric cancer by Wang, Ling, Xu, Stacey, Benatar, Tania, Prosser, Suzanna, Shaver, Laura, Randhawa, Ritu, Ip, Philbert, Lal, Prabha, Nitya-Nootan, Thanyashanthi, MacGregor, Heather, Sengupta, Sadhak, Helsen, Christopher, Bader, Andreas

“…BackgroundThe T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the re-direction of T cells to tumor cells and activates…”
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Abstract 572: Pre-clinical evaluation of Claudin 18.2 TAC T cells for the treatment of gastric cancer by Benatar, Tania, Wang, Ling, Nitya-Nootan, Thanyashanthi, MacGregor, Heather, Prosser, Suzanna, Ip, Philbert, Lal, Prabha, Shaver, Laura, Sengupta, Sadhak, Helsen, Christopher W., Bader, Andreas G.

“…Background: The T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the re-direction of T cells to tumor cells and…”
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Abstract 1773: Preclinical characterization of allogeneic Vγ9Vδ2 HER2-TAC T cells for the treatment of HER2-positive solid tumors by Prosser, Suzanna L., Xu, Stacey X., Wang, Ling, Randhawa, Ritu R., Pirati, Sailaja, Ravensbergen, Laura, Yoo, Seungmi, Jung, Miyoung, Gheorghiu, Laurentia, Gomez, Angel, Sandhu, Gurleen, Ayers, Chris, Rill, Donna, Helsen, Christopher W., Bader, Andreas G.

“…Background: The T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the redirection of T cells to tumor cells and activates…”
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Abstract 3188: Patient-derived TAC01-HER2 TAC T cells produced in Cocoon® Platform is highly functional in models of solid tumors by Wang, Ling, Xu, Stacey X., Benatar, Tania, Randhawa, Ritu R., Ip, Philbert, Lal, Prabha, Nitya-Nootan, Thanyashanthi, Ravensbergen, Laura, MacGregor, Heather, Prosser, Suzy, Sengupta, Sadhak, Helsen, Christopher W., Bader, Andreas G.

“…Background: The T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the re-direction of T cells to tumor cells and…”
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