Search Results - "Helps, Nicholas R"

Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication by Heidel, Andrew J, Lawal, Hajara M, Felder, Marius, Schilde, Christina, Helps, Nicholas R, Tunggal, Budi, Rivero, Francisco, John, Uwe, Schleicher, Michael, Eichinger, Ludwig, Platzer, Matthias, Noegel, Angelika A, Schaap, Pauline, Glöckner, Gernot

“…Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas,…”
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SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein by Browne, Gareth J, Fardilha, Margarida, Oxenham, Senga K, Wu, Wenjuan, Helps, Nicholas R, da Cruz E Silva, Odete A B, Cohen, Patricia T W, da Cruz E Silva, Edgar F

“…PP1 (protein phosphatase 1) is a ubiquitously expressed serine/threonine-specific protein phosphatase whose activity towards different substrates appears to be…”
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NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 by HELPS, Nicholas R., LUO, Xinmei, BARKER, Hazel M., COHEN, Patricia T. W.

“…The cell cycle-regulated protein serine/threonine NIMA-related kinase 2 (Nek2), which shows a predominant localization at centrosomes, is identified as a…”
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Cellular Mechanisms Regulating Protein Phosphatase-1 by Connor, John H., Frederick, Deborah, Huang, Hsien-bin, Yang, Jie, Helps, Nicholas R., Cohen, Patricia T.W., Nairn, Angus C., DePaoli-Roach, Anna, Tatchell, Kelly, Shenolikar, Shirish

“…Inhibitor-1 (I-1) and inhibitor-2 (I-2) selectively inhibit type 1 protein serine/threonine phosphatases (PP1). To define the molecular basis for PP1…”
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5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2Ac by Davies, S P, Helps, N R, Cohen, P T, Hardie, D G

“…Human protein phosphatase‐2Cα (PP2Cα) was purified to homogeneity after expression in Escherichia coli. AMP inhibited the dephosphorylation of AMP‐activated…”
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NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 by Helps, N R, Luo, X, Barker, H M, Cohen, P T

“…The cell cycle-regulated protein serine/threonine NIMA-related kinase 2 (Nek2), which shows a predominant localization at centrosomes, is identified as a…”
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Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution by Das, A. K., Helps, N. R., Cohen, P. T., Barford, D.

“…Protein phosphatase 2C (PP2C) is a Mn2+‐ or Mg2+‐dependent protein Ser/Thr phosphatase that is essential for regulating cellular stress responses in…”
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Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53 by Helps, Nicholas R., Barker, Hazel M., Elledge, Stephen J., Cohen, Patricia T.W.

“…The p53 binding protein, termed p53BP2, was identified as a protein interacting with protein phosphatase 1 (PP1) in the yeast two hybrid system. The…”
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Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos by Helps, N.R, Brewis, N.D, Lineruth, K, Davis, T, Kaiser, K, Cohen, P.T.W

“…The protein serine/threonine phosphatase 4 (PP4), which localises to centrosomes/spindle pole bodies in human cells, is shown to exhibit a similar localisation…”
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Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit by Connor, J H, Frederick, D, Huang, H b, Yang, J, Helps, N R, Cohen, P T, Nairn, A C, DePaoli-Roach, A, Tatchell, K, Shenolikar, S

“…Inhibitor-1 (I-1) and inhibitor-2 (I-2) selectively inhibit type 1 protein serine/threonine phosphatases (PP1). To define the molecular basis for PP1…”
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Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition by Helps, Nicholas R., Cohen, Patricia T.W.

“…A database search with human protein phosphatase inhibitor-2 (I-2) identified a Drosophila melanogaster cDNA that encoded a protein identical in length and…”
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Interaction with Protein Phosphatase 1 Is Essential for bifocal Function during the Morphogenesis of theDrosophila Compound Eye by Nicholas R. Helps, Patricia T. W. Cohen, Sami M. Bahri, William Chia, Kavita Babu

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interaction with Protein Phosphatase 1 Is Essential for bifocal Function during the Morphogenesis of the Drosophila Compound Eye by Helps, Nicholas R., Cohen, Patricia T. W., Bahri, Sami M., Chia, William, Babu, Kavita

“…The gene bifocal (bif), required for photoreceptor morphogenesis in the Drosophila compound eye, encodes a protein that is shown to interact with protein…”
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Characterisation of a novel Drosophila melanogaster testis specific PP1 inhibitor related to mammalian inhibitor-2: identification of the site of interaction with PP1 by Helps, Nicholas R., Vergidou, Cornillia, Gaskell, Terri, Cohen, Patricia T.W.

“…A novel Drosophila melanogaster protein, termed inhibitor-t, that bears 41% sequence similarity to human protein phosphatase inhibitor-2 has been identified…”
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Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli by Helps, Nicholas R., Street, Alasdair J., Elledge, Stephen J., Cohen, Patricia T.W.

“…The yeast two hybrid system has been employed to identify cDNAs encoding proteins which interact with the γ 1, isoform of human protein phosphatase 1. Here we…”
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5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C α and native bovine protein phosphatase-2A c by Davies, Stephen P., Helps, Nicholas R., Cohen, Patricia T.W., Hardie, D. Grahame

“…Human protein phosphatase-2C α (PP2C α) was purified to homogeneity after expression in Escherichia coli. AMP inhibited the dephosphorylation of AMP-activated…”
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