Search Results - "Helms, J"

Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels by Haaker, Maya W., Vaandrager, Arie B., Helms, J. Bernd

“…Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the immune response and the development of metabolic syndrome…”
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Identification of a candidate therapeutic autophagy-inducing peptide by Shoji-Kawata, Sanae, Sumpter, Rhea, Leveno, Matthew, Campbell, Grant R., Zou, Zhongju, Kinch, Lisa, Wilkins, Angela D., Sun, Qihua, Pallauf, Kathrin, MacDuff, Donna, Huerta, Carlos, Virgin, Herbert W., Helms, J. Bernd, Eerland, Ruud, Tooze, Sharon A., Xavier, Ramnik, Lenschow, Deborah J., Yamamoto, Ai, King, David, Lichtarge, Olivier, Grishin, Nick V., Spector, Stephen A., Kaloyanova, Dora V., Levine, Beth

“…The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,…”
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Climate, geography, and the mating phenology of ants by Helms, J. A.

“…Understanding an organism’s phenology is crucial for predicting the effects of anthropogenic impacts like climate change. Yet we lack a basic understanding of…”
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Oleic Acid Prevents Detrimental Effects of Saturated Fatty Acids on Bovine Oocyte Developmental Competence by AARDEMA, Hilde, VOS, Peter L. A. M, LOLICATO, Francesca, ROELEN, Bernard A. J, KNIJN, Hiemke M, VAANDRAGER, Arie B, BERND HELMS, J, GADELLA, Bart M

“…Mobilization of fatty acids from adipose tissue during metabolic stress will increase the amount of free fatty acids in blood and follicular fluid and, thus,…”
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The fate of porcine sperm CRISP2 from the perinuclear theca before and after in vitro fertilization by Zhang, Min, Bromfield, Elizabeth G., Helms, J. Bernd, Gadella, Bart M.

“…In a previous study, we reported that porcine sperm cysteine-rich secretory protein 2 (CRISP2) is localized in the post-acrosomal sheath-perinuclear theca (PT)…”
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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons by van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.

“…Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer’s disease (AD) may arise from altered cholesterol metabolism,…”
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Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion by Cebollero, Eduardo, van der Vaart, Aniek, Zhao, Mantong, Rieter, Ester, Klionsky, Daniel J., Helms, J. Bernd, Reggiori, Fulvio

“…The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of…”
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Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts by Helms, Erin J, Berry, Mark W, Chaw, R Crystal, DuFort, Christopher C, Sun, Duanchen, Onate, M Kathrina, Oon, Chet, Bhattacharyya, Sohinee, Sanford-Crane, Hannah, Horton, Wesley, Finan, Jennifer M, Sattler, Ariana, Makar, Rosemary, Dawson, David W, Xia, Zheng, Hingorani, Sunil R, Sherman, Mara H

“…Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood…”
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A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing by Yuan, X., Pei, X., Zhao, Y., Tulu, U.S., Liu, B., Helms, J.A.

“…Stem cells residing in the periodontal ligament (PDL) support the homeostasis of the periodontium, but their in vivo identity, source(s), and function(s)…”
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Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence by Arroyo-Olarte, Ruben D, Brouwers, Jos F, Kuchipudi, Arunakar, Helms, J Bernd, Biswas, Aindrila, Dunay, Ildiko R, Lucius, Richard, Gupta, Nishith

“…The major membrane phospholipid classes, described thus far, include phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine…”
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Retinyl esters form lipid droplets independently of triacylglycerol and seipin by Molenaar, Martijn R., Yadav, Kamlesh K., Toulmay, Alexandre, Wassenaar, Tsjerk A., Mari, Muriel C., Caillon, Lucie, Chorlay, Aymeric, Lukmantara, Ivan E., Haaker, Maya W., Wubbolts, Richard W., Houweling, Martin, Vaandrager, Arie Bas, Prieur, Xavier, Reggiori, Fulvio, Choudhary, Vineet, Yang, Hongyuan, Schneiter, Roger, Thiam, Abdou Rachid, Prinz, William A., Helms, J. Bernd

“…Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine…”
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LION/web: a web-based ontology enrichment tool for lipidomic data analysis by Molenaar, Martijn R, Jeucken, Aike, Wassenaar, Tsjerk A, van de Lest, Chris H A, Brouwers, Jos F, Helms, J Bernd

“…Abstract Background A major challenge for lipidomic analyses is the handling of the large amounts of data and the translation of results to interpret the…”
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Regulation of Functional Protein Aggregation by Multiple Factors: Implications for the Amyloidogenic Behavior of the CAP Superfamily Proteins by Sheng, Jie, Olrichs, Nick K, Gadella, Bart M, Kaloyanova, Dora V, Helms, J Bernd

“…The idea that amyloid fibrils and other types of protein aggregates are toxic for cells has been challenged by the discovery of a variety of functional…”
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Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids by Jeucken, Aike, Helms, J. Bernd, Brouwers, Jos F.

“…E. coli has three Cls-isoenzymes for cardiolipin (CL) synthesis but the differences between these three enzymes remain unresolved. All three Cls enzymes…”
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Lipidomic profiling of rat hepatic stellate cells during activation reveals a two-stage process accompanied by increased levels of lysosomal lipids by Molenaar, Martijn R., Haaker, Maya W., Vaandrager, A. Bas, Houweling, Martin, Helms, J. Bernd

“…Hepatic stellate cells (HSCs) are liver-resident cells best known for their role in vitamin A storage under physiological conditions. Upon liver injury, HSCs…”
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Multiscale Analyses of the Bone-implant Interface by Cha, J.Y., Pereira, M.D., Smith, A.A., Houschyar, K.S., Yin, X., Mouraret, S., Brunski, J.B., Helms, J.A.

“…Implants placed with high insertion torque (IT) typically exhibit primary stability, which enables early loading. Whether high IT has a negative impact on…”
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Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking by Helms, J. Bernd, Zurzolo, Chiara

“…Our view of biological membranes has evolved dramatically over the last few decades. In the bilayer model from Singer & Nicholson (Science 1972;175:720–731),…”
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Effects of Condensation on Peri-implant Bone Density and Remodeling by Wang, L., Wu, Y., Perez, K.C., Hyman, S., Brunski, J.B., Tulu, U., Bao, C., Salmon, B., Helms, J.A.

“…Bone condensation is thought to densify interfacial bone and thus improve implant primary stability, but scant data substantiate either claim. We developed a…”
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A critical analysis on quality‐of‐life in women with visible facial disfigurements by Okine, E., Helms, J. A., Luhrmann, T.

“…Aims This study aimed to examine whether surgical treatment for a facial disfigurement influenced an individual's quality of life. Methods and Results…”
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The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization by Sheng, Jie, Gadella, Bart M., Olrichs, Nick K., Kaloyanova, Dora V., Helms, J. Bernd

“…Cysteine-rich secretory proteins (CRISPs) are a subgroup of the CRISP, antigen 5 and PR-1 (CAP) superfamily that is characterized by the presence of a…”
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