Search Results - "Helmrath, Michael A."

Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents by Inge, Thomas H, Courcoulas, Anita P, Jenkins, Todd M, Michalsky, Marc P, Helmrath, Michael A, Brandt, Mary L, Harmon, Carroll M, Zeller, Meg H, Chen, Mike K, Xanthakos, Stavra A, Horlick, Mary, Buncher, C. Ralph

“…In this study, adolescents undergoing bariatric surgery were followed for 3 years. They had improvements in weight, cardiometabolic health, and quality of…”
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An in vivo model of human small intestine using pluripotent stem cells by Watson, Carey L, Mahe, Maxime M, Múnera, Jorge, Howell, Jonathan C, Sundaram, Nambirajan, Poling, Holly M, Schweitzer, Jamie I, Vallance, Jefferson E, Mayhew, Christopher N, Sun, Ying, Grabowski, Gregory, Finkbeiner, Stacy R, Spence, Jason R, Shroyer, Noah F, Wells, James M, Helmrath, Michael A

“…An in vivo model of the human small intestine is established in mice using human pluripotent stem cells. Differentiation of human pluripotent stem cells…”
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The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas by McGrath, Patrick S, Watson, Carey L, Ingram, Cameron, Helmrath, Michael A, Wells, James M

“…Neurogenin3 (NEUROG3) is a basic helix-loop-helix transcription factor required for development of the endocrine pancreas in mice. In contrast, humans with…”
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PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease by Moreno-Fernandez, Maria E., Giles, Daniel A., Oates, Jarren R., Chan, Calvin C., Damen, Michelle S.M.A., Doll, Jessica R., Stankiewicz, Traci E., Chen, Xiaoting, Chetal, Kashish, Karns, Rebekah, Weirauch, Matthew T., Romick-Rosendale, Lindsey, Xanthakos, Stavra A., Sheridan, Rachel, Szabo, Sara, Shah, Amy S., Helmrath, Michael A., Inge, Thomas H., Deshmukh, Hitesh, Salomonis, Nathan, Divanovic, Senad

“…Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and…”
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CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation by Bertaux-Skeirik, Nina, Feng, Rui, Schumacher, Michael A, Li, Jing, Mahe, Maxime M, Engevik, Amy C, Javier, Jose E, Peek, Jr, Richard M, Ottemann, Karen, Orian-Rousseau, Veronique, Boivin, Gregory P, Helmrath, Michael A, Zavros, Yana

“…The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA…”
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Long-term outcomes of bariatric surgery in adolescents with severe obesity (FABS-5+): a prospective follow-up analysis by Inge, Thomas H, Dr, Jenkins, Todd M, PhD, Xanthakos, Stavra A, MD, Dixon, John B, PhD, Daniels, Stephen R, MD, Zeller, Meg H, PhD, Helmrath, Michael A, MD

“…Summary Background Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of…”
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Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells by Nalapareddy, Kodandaramireddy, Nattamai, Kalpana J., Kumar, Rupali S., Karns, Rebekah, Wikenheiser-Brokamp, Kathryn A., Sampson, Leesa L., Mahe, Maxime M., Sundaram, Nambirajan, Yacyshyn, Mary-Beth, Yacyshyn, Bruce, Helmrath, Michael A., Zheng, Yi, Geiger, Hartmut

“…Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in…”
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Evaluation of transplantation sites for human intestinal organoids by Singh, Akaljot, Poling, Holly M, Sundaram, Nambirajan, Brown, Nicole, Wells, James M, Helmrath, Michael A

“…Our group has developed two transplantation models for the engraftment of Human Intestinal Organoids (HIOs): the renal subcapsular space (RSS) and the…”
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Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo by Finkbeiner, Stacy R., Hill, David R., Altheim, Christopher H., Dedhia, Priya H., Taylor, Matthew J., Tsai, Yu-Hwai, Chin, Alana M., Mahe, Maxime M., Watson, Carey L., Freeman, Jennifer J., Nattiv, Roy, Thomson, Matthew, Klein, Ophir D., Shroyer, Noah F., Helmrath, Michael A., Teitelbaum, Daniel H., Dempsey, Peter J., Spence, Jason R.

“…Human intestinal organoids (HIOs) are a tissue culture model in which small intestine-like tissue is generated from pluripotent stem cells. By carrying out…”
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Ontogeny and function of the circadian clock in intestinal organoids by Rosselot, Andrew E, Park, Miri, Kim, Mari, Matsu‐Ura, Toru, Wu, Gang, Flores, Danilo E, Subramanian, Krithika R, Lee, Suengwon, Sundaram, Nambirajan, Broda, Taylor R, McCauley, Heather A, Hawkins, Jennifer A, Chetal, Kashish, Salomonis, Nathan, Shroyer, Noah F, Helmrath, Michael A, Wells, James M, Hogenesch, John B, Moore, Sean R, Hong, Christian I

“…Circadian rhythms regulate diverse aspects of gastrointestinal physiology ranging from the composition of microbiota to motility. However, development of the…”
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Type I interferon sensing unlocks dormant adipocyte inflammatory potential by Chan, Calvin C., Damen, Michelle S. M. A., Moreno-Fernandez, Maria E., Stankiewicz, Traci E., Cappelletti, Monica, Alarcon, Pablo C., Oates, Jarren R., Doll, Jessica R., Mukherjee, Rajib, Chen, Xiaoting, Karns, Rebekah, Weirauch, Matthew T., Helmrath, Michael A., Inge, Thomas H., Divanovic, Senad

“…White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory…”
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Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport by McCauley, Heather A., Matthis, Andrea L., Enriquez, Jacob R., Nichol, Jonah T., Sanchez, J. Guillermo, Stone, William J., Sundaram, Nambirajan, Helmrath, Michael A., Montrose, Marshall H., Aihara, Eitaro, Wells, James M.

“…The ability to absorb ingested nutrients is an essential function of all metazoans and utilizes a wide array of nutrient transporters found on the absorptive…”
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Deriving functional human enteroendocrine cells from pluripotent stem cells by Sinagoga, Katie L, McCauley, Heather A, Múnera, Jorge O, Reynolds, Nichole A, Enriquez, Jacob R, Watson, Carey, Yang, Hsiu-Chiung, Helmrath, Michael A, Wells, James M

“…Enteroendocrine cells (EECs) are a minor cell population in the intestine yet they play a major role in digestion, satiety and nutrient homeostasis. Recently…”
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Intestine-Specific Ablation of Mouse atonal homolog 1 ( Math1 ) Reveals a Role in Cellular Homeostasis by Shroyer, Noah F, Helmrath, Michael A, Wang, Vincent Y.–C, Antalffy, Barbara, Henning, Susan J, Zoghbi, Huda Y

“…Background & Aims: Math1 ( Atoh1 ) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized…”
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CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium by Bertaux‐Skeirik, Nina, Wunderlich, Mark, Teal, Emma, Chakrabarti, Jayati, Biesiada, Jacek, Mahe, Maxime, Sundaram, Nambirajan, Gabre, Joel, Hawkins, Jennifer, Jian, Gao, Engevik, Amy C, Yang, Li, Wang, Jiang, Goldenring, James R, Qualls, Joseph E, Medvedovic, Mario, Helmrath, Michael A, Diwan, Tayyab, Mulloy, James C, Zavros, Yana

“…The CD44 gene encodes several protein isoforms due to alternative splicing and post translational modifications. Given that CD44 variant isoform 9 (CD44v9) is…”
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Expansion of intestinal epithelial stem cells during murine development by Dehmer, Jeffrey J, Garrison, Aaron P, Speck, Karen E, Dekaney, Christopher M, Van Landeghem, Laurianne, Sun, Xiaofei, Henning, Susan J, Helmrath, Michael A

“…Murine small intestinal crypt development is initiated during the first postnatal week. Soon after formation, overall increases in the number of crypts occurs…”
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Multiple Micronutrient Deficiencies among Patients with Intestinal Failure during and after Transition to Enteral Nutrition by Ubesie, Agozie C., MBBS, MPH, Kocoshis, Samuel A., MD, Mezoff, Adam G., MD, Henderson, Carol J., RD, PhD, Helmrath, Michael A., MD, Cole, Conrad R., MD, MPH, MSc

“…Objectives To determine the prevalence of deficiencies of specific micronutrients (iron, zinc, magnesium, phosphorus, selenium, copper, folate, and vitamins A,…”
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Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid by Aihara, Eitaro, Mahe, Maxime M., Schumacher, Michael A., Matthis, Andrea L., Feng, Rui, Ren, Wenwen, Noah, Taeko K., Matsu-ura, Toru, Moore, Sean R., Hong, Christian I., Zavros, Yana, Herness, Scott, Shroyer, Noah F., Iwatsuki, Ken, Jiang, Peihua, Helmrath, Michael A., Montrose, Marshall H.

“…Leucine-rich repeat-containing G-protein coupled receptor 5-expressing (Lgr5 + ) cells have been identified as stem/progenitor cells in the circumvallate…”
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In Vivo Model of Small Intestine by Mahe, Maxime M, Brown, Nicole E, Poling, Holly M, Helmrath, Michael A

“…The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and…”
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Mechanically induced development and maturation of human intestinal organoids in vivo by Poling, Holly M., Wu, David, Brown, Nicole, Baker, Michael, Hausfeld, Taylor A., Huynh, Nhan, Chaffron, Samuel, Dunn, James C. Y., Hogan, Simon P., Wells, James M., Helmrath, Michael A., Mahe, Maxime M.

“…The natural ability of stem cells to self-organize into functional tissue has been harnessed for the production of functional human intestinal organoids…”
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