Search Results - "Helmling, S."

Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats by Kobelt, P, Helmling, S, Stengel, A, Wlotzka, B, Andresen, V, Klapp, B F, Wiedenmann, B, Klussmann, S, Mönnikes, H

“…Background and aims: Ghrelin, the natural ligand of the growth hormone secretagogue receptor 1a, is the most powerful peripherally active orexigenic agent…”
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Structure of Yeast Poly(A) Polymerase Alone and in Complex with 3′-dATP by Bard, Joel, Zhelkovsky, Alexander M., Helmling, Steffen, Earnest, Thomas N., Moore, Claire L., Bohm, Andrew

“…Polyadenylate [poly(A)] polymerase (PAP) catalyzes the addition of a polyadenosine tail to almost all eukaryotic messenger RNAs (mRNAs). The crystal structure…”
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A New Class of Spiegelmers Containing 2′-Fluoro-nucleotides by Helmling, S., Moyroud, E., Schroeder, W., Roehl, I., Kleinjung, F., Stark, S., Bahrenberg, G., Gillen, C., Klussmann, S., Vonhoff, S.

“…Synthesis of 2′-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2′-fluoro-Spiegelmers binding to a neuropeptide…”
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Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice by Shearman, Lauren P, Wang, Sheng-Ping, Helmling, Steffen, Stribling, D. Sloan, Mazur, Paul, Ge, Lan, Wang, Liyang, Klussmann, Sven, Macintyre, D. Euan, Howard, Andrew D, Strack, Alison M

“…Ghrelin, an acylated peptide secreted from the stomach, acts as a short-term signal of nutrient depletion. Ghrelin is an endogenous ligand for the GH…”
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Inhibition of Ghrelin Action in vitro and in vivo by an RNA-Spiegelmer by Helmling, Steffen, Maasch, Christian, Eulberg, Dirk, Buchner, Klaus, Schröder, Werner, Lange, Christian, Vonhoff, Stefan, Wlotzka, Britta, Tschöp, Matthias H., Rosewicz, Stefan, Klussmann, Sven, Steiner, Donald F.

“…Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the…”
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Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor by Tacahashi, Yoko, Helmling, Steffen, Moore, Claire L.

“…Yth1, a subunit of yeast Cleavage Polyadenylation Factor (CPF), contains five CCCH zinc fingers. Yth1 was previously shown to interact with pre‐mRNA and with…”
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Fip1 Regulates the Activity of Poly(A) Polymerase through Multiple Interactions by Helmling, Steffen, Zhelkovsky, Alexander, Moore, Claire L.

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Pta1, a Component of Yeast CF II, Is Required for Both Cleavage and Poly(A) Addition of mRNA Precursor by Zhao, J, Kessler, M, Helmling, S, O'Connor, J P, Moore, C

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Mutations in the middle domain of yeast poly(A) polymerase affect interactions with RNA but not ATP by Zhelkovsky, Alexander, Helmling, Steffen, Bohm, Andrew, Moore, Claire

“…The eukaryotic poly(A) polymerase (PAP) is responsible for the posttranscriptional extension of mRNA 3' ends by the addition of a poly(A) tract. The recently…”
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Processivity of the Saccharomyces cerevisiae Poly(A) Polymerase Requires Interactions at the Carboxyl-Terminal RNA Binding Domain by Zhelkovsky, Alexander, Helmling, Steffen, Moore, Claire

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Anti-ghrelin spiegelmer NOX-b11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Commentary by HORNBY, P. J, KOBELT, P, HELMLING, S, STENGEL, A, WLOTZKA, B, ANDRESEN, V, KLAPP, B. F, WIEDENMANN, B, KLUSSMANN, S, MÖNNIKES, H

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Joyce, Pound, and Dr. Poindejenk by Helmling, Steven

“…James Joyce's "Finnegans Wake" is discussed. The character of Dr. Poindejenk is Ezra Pound among others…”
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The Bible and Secular Culture by Helmling, Steven

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Joyce the Irresponsible by Helmling, Steven

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The Grin of Tiresias: Humor in The Waste Land by Helmling, Steven

“…An examination of irony, humor and self-caricature in T. S. Eliot's poem "The Waste Land" is offered…”
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The promise of ghrelin antagonism in obesity treatment by Helmling, Steffen, Jarosch, Florian, Klussmann, Sven

“…According to the World Health Organization, 300 million people are clinically obese worldwide. As a major risk factor in the development of life-threatening…”
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Recent African-American Biography and Criticism by Helmling, Steven

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