Search Results - "Helminen, H. J."

Composition, structure and tensile biomechanical properties of equine articular cartilage during growth and maturation by Oinas, J., Ronkainen, A. P., Rieppo, L., Finnilä, M. A. J., Iivarinen, J. T., van Weeren, P. R., Helminen, H. J., Brama, P. A. J., Korhonen, R. K., Saarakkala, S.

“…Articular cartilage undergoes structural and biochemical changes during maturation, but the knowledge on how these changes relate to articular cartilage…”
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Normal and pathological adaptations of articular cartilage to joint loading by Arokoski, J. P. A., Jurvelin, J. S., Väätäinen, U., Helminen, H. J.

“…Joints are functional units that transmit mechanical loads between contacting bones during normal daily or specialized activities, e.g., sports. All components…”
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Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation by Korhonen, R.K, Laasanen, M.S, Töyräs, J, Rieppo, J, Hirvonen, J, Helminen, H.J, Jurvelin, J.S

“…At mechanical equilibrium, articular cartilage is usually characterized as an isotropic elastic material with no interstitial fluid flow. In this study, the…”
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Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound by Töyräs, J, Rieppo, J, Nieminen, M T, Helminen, H J, Jurvelin, J S

“…Ultrasound may provide a quantitative technique for the characterization of cartilage changes typical of early osteoarthrosis. In this study, specific changes…”
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Importance of the superficial tissue layer for the indentation stiffness of articular cartilage by Korhonen, R.K, Wong, M, Arokoski, J, Lindgren, R, Helminen, H.J, Hunziker, E.B, Jurvelin, J.S

“…Indentation testing is a widely used technique for nondestructive mechanical analysis of articular cartilage. Although cartilage shows an inhomogeneous,…”
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Application of second derivative spectroscopy for increasing molecular specificity of fourier transform infrared spectroscopic imaging of articular cartilage by Rieppo, L, Saarakkala, S, Närhi, T, Helminen, H.J, Jurvelin, J.S, Rieppo, J

“…Summary Objective Fourier transform infrared (FT-IR) spectroscopic imaging is a promising method that enables the analysis of spatial distribution of…”
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Hsp70 Accumulation in Chondrocytic Cells Exposed to High Continuous Hydrostatic Pressure Coincides with mRNA Stabilization rather than Transcriptional Activation by Kaarniranta, K., Elo, M., Sironen, R., Lammi, M. J., Goldring, M. B., Eriksson, J. E., Sistonen, L., Helminen, H. J.

“…In response to various stress stimuli, heat shock genes are induced to express heat shock proteins (Hsps). Previous studies have revealed that expression of…”
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Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis by Helminen, H. J., Säämänen, A.‐M., Salminen, H., Hyttinen, M. M.

“…The development of transgenic technology has made possible the generation of targeted gene‐mutated mouse lines suitable for use in experimental osteoarthritis…”
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Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis by Brommer, H, Brama, P.A.J, Laasanen, M.S, Helminen, H.J, Weeren, P.R. van, Jurvelin, J.S

“…Summary Reasons for performing study: The concept of functional adapatation of articular cartilage during maturation has emerged from earlier biochemical…”
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Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis by Arokoski, J P A, Arokoski, M H, Jurvelin, J S, Helminen, H J, Niemitukia, L H, Kröger, H

“…Objectives: Even though clinical findings support the idea that hip osteoarthritis (OA) is associated with increased bone mineral density (BMD), the subject…”
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Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility by Li, S W, Arita, M, Fertala, A, Bao, Y, Kopen, G C, Långsjö, T K, Hyttinen, M M, Helminen, H J, Prockop, D J

“…Transgenic mice were prepared with inactive alleles for procollagen N-proteinase (ADAMTS-2; where ADAMTS stands for a disintegrin and metalloproteinase with…”
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Remobilization does not fully restore immobilization induced articular cartilage atrophy by Haapala, J, Arokoski, J P, Hyttinen, M M, Lammi, M, Tammi, M, Kovanen, V, Helminen, H J, Kiviranta, I

“…The recovery of articular cartilage from immobilization induced atrophy was studied. The right hind limbs of 29-week-old beagle dogs were immobilized for 11…”
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Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer by Hyttinen, M M, Töyräs, J, Lapveteläinen, T, Lindblom, J, Prockop, D J, Li, S-W, Arita, M, Jurvelin, J S, Helminen, H J

“…OBJECTIVE To evaluate the influence of inactivation of one allele (“heterozygous knockout” or “heterozygous inactivation”) of the type II procollagen gene…”
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Site-specific immunostaining for type X collagen in noncalcified articular cartilage of canine stifle knee joint by Lammi, P.E, Lammi, M.J, Hyttinen, M.M, Panula, H, Kiviranta, I, Helminen, H.J

“…Type X collagen is a short-chain collagen that is strongly expressed in hypertrophic chondrocytes. In this study, we used an immunohistochemical technique…”
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Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation by Rieppo, J., M.D, Hyttinen, M.M., M.D, Halmesmaki, E., M.D, Ruotsalainen, H., M.Sc, Vasara, A., M.D., Ph.D, Kiviranta, I., M.D., Ph.D, Jurvelin, J.S., Ph.D, Helminen, H.J., M.D., Ph.D

“…Summary Objectives The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and…”
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Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage by Julkunen, P, Harjula, T, Iivarinen, J, Marjanen, J, Seppänen, K, Närhi, T, Arokoski, J, Lammi, M.J, Brama, P.A, Jurvelin, J.S, Helminen, H.J

“…Summary Objective The structure and composition of articular cartilage change during development and growth. These changes lead to alterations in the…”
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Articular cartilage superficial zone collagen birefringence reduced and cartilage thickness increased before surface fibrillation in experimental osteoarthritis by Panula, Harri E, Hyttinen, Mika M, Arokoski, Jari P A, Långsjö, Teemu K, Pelttari, Alpo, Kiviranta, Ilkka, Helminen, Heikki J

“…OBJECTIVES To investigate articular cartilage collagen network, thickness of birefringent cartilage zones, and glycosaminoglycan concentration in…”
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Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats by Vasara, A I, Hyttinen, M M, Lammi, M J, Lammi, P E, Långsjö, T K, Lindahl, A, Peterson, L, Kellomäki, M, Konttinen, Y T, Helminen, H J, Kiviranta, I

“…Repair of cartilage damage with autologous chondrocyte transplantation (ACT) has become popular in clinical use during the past few years. Although clinical…”
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Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs by Haapala, J, Arokoski, J P A, Rönkkö, S, Ågren, U, Kosma, V-M, Lohmander, L S, Tammi, M, Helminen, H J, Kiviranta, I

“…OBJECTIVE To monitor the concentration of markers of cartilage and synovium metabolism in the knee (stifle) joint synovial fluid of young beagles subjected to…”
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Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate by Mäkelä, O T, Lammi, M J, Uusitalo, H, Hyttinen, M M, Vuorio, E, Helminen, H J, Tulamo, R-M

“…Objective: To study the short and long term effects of radiosynovectomy on articular cartilage in growing and mature rabbits. Methods: The articular cartilage…”
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