Search Results - "Helmfors, Linda"

Protective properties of lysozyme on β-amyloid pathology: implications for Alzheimer disease by Helmfors, Linda, Boman, Andrea, Civitelli, Livia, Nath, Sangeeta, Sandin, Linnea, Janefjord, Camilla, McCann, Heather, Zetterberg, Henrik, Blennow, Kaj, Halliday, Glenda, Brorsson, Ann-Christin, Kågedal, Katarina

“…Abstract The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major…”
Get full text

Serum Amyloid P Component Ameliorates Neurological Damage Caused by Expressing a Lysozyme Variant in the Central Nervous System of Drosophila melanogaster by Helmfors, Linda, Bergkvist, Liza, Brorsson, Ann-Christin

“…Lysozyme amyloidosis is a hereditary disease in which mutations in the gene coding for lysozyme leads to misfolding and consequently accumulation of amyloid…”
Get full text

Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner by Pathak, Surajit, Meng, Wen-Jian, Nandy, Suman Kumar, Ping, Jie, Bisgin, Atil, Helmfors, Linda, Waldmann, Patrik, Sun, Xiao-Feng

“…Aberrant expression of miRNAs, cytokines and chemokines are involved in pathogenesis of colon cancer. However, the expression of p53 mediated miRNAs, cyto- and…”
Get full text

Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster by Sandin, Linnea, Bergkvist, Liza, Nath, Sangeeta, Kielkopf, Claudia, Janefjord, Camilla, Helmfors, Linda, Zetterberg, Henrik, Blennow, Kaj, Li, Hongyun, Nilsberth, Camilla, Garner, Brett, Brorsson, Ann‐Christin, Kågedal, Katarina

“…Genetic polymorphisms of immune genes that associate with higher risk to develop Alzheimer's disease (AD) have led to an increased research interest on the…”
Get full text

Understanding the Dual Nature of Lysozyme: Part Villain – Part Hero A Drosophila melanogaster Model of Lysozyme Amyloidosis by Helmfors, Linda

“…Amyloid proteins are a distinct class of proteins that can misfold into β-sheet rich structures that later mature to form the characteristic species known as…”
Get full text

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster by Kumita, Janet R., Helmfors, Linda, Williams, Jocy, Luheshi, Leila M., Menzer, Linda, Dumoulin, Mireille, Lomas, David A., Crowther, Damian C., Dobson, Christopher M., Brorsson, Ann‐Christin

“…ABSTRACT We have created a Drosophila model of lysozyme amyloidosis to investigate the in vivo behavior of disease‐associated variants. To achieve this…”
Get full text