Search Results - "Helmes, M"

Automatic detection of adult cardiomyocyte for high throughput measurements of calcium and contractility by Cao, L, Manders, E, Helmes, M

“…Simultaneous calcium and contractility measurements on isolated adult cardiomyocytes have been the gold standard for the last decades to study cardiac…”
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Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness by Cazorla, O, Freiburg, A, Helmes, M, Centner, T, McNabb, M, Wu, Y, Trombitás, K, Labeit, S, Granzier, H

“…Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac muscle. Previous studies of human cardiac titin transcripts…”
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Mechanically Driven Contour-Length Adjustment in Rat Cardiac Titin's Unique N2B Sequence: Titin Is an Adjustable Spring by Helmes, M, Trombitas, K, Centner, T, Kellermayer, M, Labeit, S, Linke, W.A, Granzier, H

“…The giant elastic protein titin is largely responsible for passive forces in cardiac myocytes. A number of different titin isoforms with distinctly different…”
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Galectin-3 binding protein, coronary artery disease and cardiovascular mortality: Insights from the LURIC study by Gleissner, Christian A, Erbel, Christian, Linden, Fabian, Domschke, Gabriele, Akhavanpoor, Mohammadreza, Helmes, Christian M, Doesch, Andreas O, Kleber, Marcus E, Katus, Hugo A, Maerz, Winfried

“…Abstract Background and aims Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role for coronary artery…”
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CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7+S100A8+ in vitro and in vivo by Erbel, Christian, Tyka, Mirjam, Helmes, Christian M, Akhavanpoor, Mohmmadreza, Rupp, Gregor, Domschke, Gabriele, Linden, Fabian, Wolf, Antonia, Doesch, Andreas, Lasitschka, Felix, Katus, Hugo A, Gleissner, Christian A

“…Macrophage heterogeneity in human atherosclerotic plaques has been recognized; however, markers for unequivocal identification of some subtypes are lacking. We…”
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Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction by Granzier, H., Kellermayer, M., Helmes, M., Trombitás, K.

“…Titin (also known as connectin) is a giant filamentous protein whose elastic properties greatly contribute to the passive force in muscle. In the sarcomere,…”
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Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics by Granzier, H., Helmes, M., Trombitás, K.

“…Titin (also known as connectin) is a muscle-specific giant protein found inside the sarcomere, spanning from the Z-line to the M-line. The I-band segment of…”
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Effects of a nurse-coordinated prevention programme on health-related quality of life and depression in patients with an acute coronary syndrome: results from the RESPONSE randomised controlled trial by Jørstad, Harald T, Minneboo, Madelon, Helmes, Harold J M, Fagel, Nick D, Scholte Op Reimer, Wilma J, Tijssen, Jan G P, Peters, Ron J G

“…Improvement of health-related quality of life (HRQOL) is an important goal in preventive cardiology. HRQOL is also related to depressive symptoms, which…”
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Mechanical properties of titin isoforms by Granzier, H, Helmes, M, Cazorla, O, McNabb, M, Labeit, D, Wu, Y, Yamasaki, R, Redkar, A, Kellermayer, M, Labeit, S, Trombitás, K

“…Titin is a giant filamentous polypeptide of multi-domain construction spanning between the Z- and M-lines of the sarcomere. As a result of differential…”
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An in vitro model to study heterogeneity of human macrophage differentiation and polarization by Erbel, Christian, Rupp, Gregor, Helmes, Christian M, Tyka, Mirjam, Linden, Fabian, Doesch, Andreas O, Katus, Hugo A, Gleissner, Christian A

“…Monocyte-derived macrophages represent an important cell type of the innate immune system. Mouse models studying macrophage biology suffer from the phenotypic…”
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CD31− but Not CD31+ Cardiac Side Population Cells Exhibit Functional Cardiomyogenic Differentiation by Pfister, Otmar, Mouquet, Frédéric, Jain, Mohit, Summer, Ross, Helmes, Michiel, Fine, Alan, Colucci, Wilson S, Liao, Ronglih

“…Heart failure remains a leading cause of morbidity and mortality. The cellular mechanism underlying the development of cardiac dysfunction is a decrease in the…”
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Empagliflozin for heart failure with preserved ejection fraction: targeting cardiac endothelial cell-cardiomyocyte interaction by Juni, R., Kuster, D.W.D., Goebel, M., Helmes, M., van der Velden, J., Musters, R., Koolwijk, P., Paulus, W., van Hinsbergh, V.

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NADH and FAD kinetics reveal altered mitochondrial function in right ventricular heart failure by Wust, R. C. I., Helmes, M., Stienen, G. J. M.

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P.163Mutations in fast skeletal troponin C (TNNC2) cause contractile dysfunction by van de Locht, M., de Winter, J., Conijn, S., Ma, W., Helmes, M., Irving, T., Donkervoort, S., Mohassel, P., Medne, L., Quinn, C., Neto, O., Moore, S., Foley, A., Pinto, J., Voermans, N., Bönnemann, C., Ottenheijm, C.

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NEW GENES, FUNCTIONS AND BIOMARKERS by van de Locht, M., Winter, J., Conijn, S., Ma, W., Helmes, M., Irving, T., Donkervoort, S., Mohassel, P., Medne, L., Quinn, C., Neto, O., Moore, S., Foley, A.R., Voermans, N., Bönnemann, C., Ottenheijm, C.

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CONGENITAL MYOPATHIES: GENERAL AND RYR1: P.41Dominant TNNC2 mutations cause a distinct congenital myopathy with vocal cord paralysis, ophthalmoplegia and clinical improvement over time by Donkervoort, S., Mohassel, P., Voermans, N., Quinn, C., van de Locht, M., de Winter, J., Conijn, S., Helmes, M., Medne, L., Lopes Abath Neto, O., Moore, S., Ottenheijm, C., Foley, A.R., Bönnemann, C.

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NEW GENES, FUNCTIONS AND BIOMARKERS: O.2Mutations in fast skeletal troponin C (TNNC2) cause contractile dysfunction by van de Locht, M., Winter, J., Conijn, S., Ma, W., Helmes, M., Irving, T., Donkervoort, S., Mohassel, P., Medne, L., Quinn, C., Neto, O., Moore, S., Foley, A.R., Voermans, N., Bönnemann, C., Ottenheijm, C.

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CONGENITAL MYOPATHIES: GENERAL AND RYR1 by Donkervoort, S., Mohassel, P., Voermans, N., Quinn, C., van de Locht, M., de Winter, J., Conijn, S., Helmes, M., Medne, L., Lopes Abath Neto, O., Moore, S., Ottenheijm, C., Foley, A.R., Bönnemann, C.

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Anthracyclines Induce Calpain-dependent Titin Proteolysis and Necrosis in Cardiomyocytes by Lim, Chee Chew, Zuppinger, Christian, Guo, Xinxin, Kuster, Gabriela M., Helmes, Michiel, Eppenberger, Hans M., Suter, Thomas M., Liao, Ronglih, Sawyer, Douglas B.

“…Titin, the largest myofilament protein, serves as a template for sarcomere assembly and acts as a molecular spring to contribute to diastolic function. Titin…”
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Titin Develops Restoring Force in Rat Cardiac Myocytes by Helmes, Michiel, Trombitas, Karoly, Granzier, Henk

“…When relaxed after contraction, isolated cardiac myocytes quickly relengthen back to their slack length. The molecular basis of the force that underlies…”
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