Search Results - "Helmerhorst, Theo J M"

To vaccinate or not to vaccinate? Perspectives on HPV vaccination among girls, boys, and parents in the Netherlands: a Q-methodological study by Patty, Nathalie J S, van Dijk, Hanna Maria, Wallenburg, Iris, Bal, Roland, Helmerhorst, Theo J M, van Exel, Job, Cramm, Jane Murray

“…Despite the introduction of Human papillomavirus (HPV) vaccination in national immunization programs (NIPs), vaccination rates in most countries remain…”
Get full text

Risk of recurrent high-grade cervical intraepithelial neoplasia after successful treatment: a long-term multi-cohort study by Kocken, Mariëlle, MD, Helmerhorst, Theo JM, Prof, Berkhof, Johannes, PhD, Louwers, Jacqueline A, MD, Nobbenhuis, Mariëlle AE, MD, Bais, Aagje G, MD, Hogewoning, Cornelis JA, MD, Zaal, Afra, MD, Verheijen, René HM, Prof, Snijders, Peter JF, Prof, Meijer, Chris JLM, Prof

“…Summary Background 15% of women treated for high-grade cervical intraepithelial neoplasia (CIN grade 2 or 3) develop residual or recurrent CIN grade 2 or 3 or…”
Get full text

Cancer risk in DES daughters by Verloop, Janneke, van Leeuwen, Flora E, Helmerhorst, Theo J. M, van Boven, Hester H, Rookus, Matti A

“…Objective We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero. Methods A total of 12,091 DES-exposed women in the…”
Get full text

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod by van Seters, Manon, van Beurden, Marc, ten Kate, Fiebo J.W, Beckmann, Ilse, Ewing, Patricia C, Eijkemans, Marinus J.C, Kagie, Marjolein J, Meijer, Chris J.M, Aaronson, Neil K, KleinJan, Alex, Heijmans-Antonissen, Claudia, Zijlstra, Freek J, Burger, Matthé P.M, Helmerhorst, Theo J.M

“…The efficacy of local treatment of vulvar intraepithelial neoplasia with imiquimod, an immune-response modifier, was tested in a double-blind, randomized…”
Get full text

Girls’ preferences for HPV vaccination: A discrete choice experiment by de Bekker-Grob, Esther W, Hofman, Robine, Donkers, Bas, van Ballegooijen, Marjolein, Helmerhorst, Theo J.M, Raat, Hein, Korfage, Ida J

“…Abstract A discrete choice experiment was developed to investigate if girls aged 12–16 years make trade-offs between various aspects of human papillomavirus…”
Get full text

Human papillomavirus testing on self‐sampled cervicovaginal brushes: An effective alternative to protect nonresponders in cervical screening programs by Bais, Aagje G., van Kemenade, Folkert J., Berkhof, Johannes, Verheijen, René H.M., Snijders, Peter J.F., Voorhorst, Feja, Babović, Milena, van Ballegooijen, Marjolein, Helmerhorst, Theo J.M., Meijer, Chris J.L.M.

“…Women not attending cervical screening programs are at increased risk of cervical cancer. We investigated in these nonresponders to what extent offering…”
Get full text

Different DNA damage and cell cycle checkpoint control in low- and high-risk human papillomavirus infections of the vulva by Santegoets, Lindy A.M., Baars, Romy van, Terlou, Annelinde, Heijmans-Antonissen, Claudia, Swagemakers, Sigrid M.A., van der Spek, Peter J., Ewing, Patricia C., Beurden, Marc van, van der Meijden, Willem I., Helmerhorst, Theo J.M., Blok, Leen J.

“…Human papillomavirus (HPV) infections may result in benign hyperplasia, caused by low‐risk HPV types, or (pre)malignant lesions caused by high‐risk HPV types…”
Get full text

Distribution Pattern and Marker Profile Show Two Subpopulations of Reserve Cells in the Endocervical Canal by Martens, Jolise E, Smedts, Frank M. M, Ploeger, Diana, Helmerhorst, Theo J. M, Ramaekers, Frans C. S, Arends, Jan W, Hopman, Anton H. N

“…A previous immunophenotyping study in the fetal uterine cervix provided evidence for the existence of 2 subpopulations of reserve cells, one giving rise to…”
Get full text

An Autoimmune Phenotype in Vulvar Lichen Sclerosus and Lichen Planus: A Th1 Response and High Levels of MicroRNA-155 by Terlou, Annelinde, Santegoets, Lindy A.M., van der Meijden, Willem I., Heijmans-Antonissen, Claudia, Swagemakers, Sigrid M.A., van der Spek, Peter J., Ewing, Patricia C., van Beurden, Marc, Helmerhorst, Theo J.M., Blok, Leen J.

“…Vulvar lichen sclerosus and lichen planus are T-cell–mediated chronic skin disorders. Although autoimmunity has been suggested, the exact pathogenesis of these…”
Get full text

Nonsteroidal anti‐inflammatory drugs do not interfere with imiquimod treatment for usual type vulvar intraepithelial neoplasia by Terlou, Annelinde, Kleinjan, Alex, Beckmann, Ilse, Heijmans‐Antonissen, Claudia, van Seters, Manon, Santegoets, Lindy A.M., van Beurden, Marc, Helmerhorst, Theo J.M., Blok, Leen J.

“…Imiquimod has been shown to be an effective treatment for usual type vulvar intraepithelial neoplasia (uVIN). Since local inflammation and burning are common…”
Get full text

Imiquimod‐induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia by Terlou, Annelinde, Seters, Manon van, Kleinjan, Alex, Heijmans‐Antonissen, Claudia, Santegoets, Lindy A.M., Beckmann, Ilse, Beurden, Marc van, Helmerhorst, Theo J.M., Blok, Leen J.

“…Recently, we reported on the efficacy of imiquimod for treatment of usual type vulvar intraepithelial neoplasia (uVIN). A histologic regression of uVIN to…”
Get full text

Quality of life assumptions determine which cervical cancer screening strategies are cost‐effective by de Kok, Inge M.C.M., Korfage, Ida J., van den Hout, Wilbert B., Helmerhorst, Theo J.M., Habbema, J. Dik F., Essink‐Bot, Marie‐Louise, van Ballegooijen, Marjolein

“…Quality‐adjusted life years are used in cost‐effectiveness analyses (CEAs). To calculate QALYs, a “utility” (0–1) is used for each health state induced or…”
Get full text

Adenocarcinoma in situ of the uterine cervix--a systematic review by Baalbergen, Astrid, Helmerhorst, Theo J M

“…This study aimed to review literature if therapeutic strategies in adenocarcinoma in situ of the cervix could lead to a more conservative approach. A review of…”
Get more information

Cytokine Release in HR-HPV(+)Women without and with Cervical Dysplasia (CIN II and III) or Carcinoma, Compared with HR-HPV(−) Controls by BAIS, Aagje G, BECKMANN, Ilse, EWING, Patricia C, EIJKEMANS, Marinus J. C, MEIJER, Chris J. L. M, SNIJDERS, Peter J. F, HELMERHORST, Theo J. M

“…We investigated the effect of HR-HPV infection on the capacity of the cytokine network in whole blood cultures during carcinogenesis of cervical carcinoma…”
Get full text

Conservative therapy in microinvasive adenocarcinoma of the uterine cervix is justified: an analysis of 59 cases and a review of the literature by Baalbergen, Astrid, Smedts, Frank, Helmerhorst, Theo J M

“…This study aimed to evaluate the treatment and follow-up in a large series of women with early cervical adenocarcinoma (AC), stages IA1 and IA2, and to perform…”
Get more information

Premalignant epithelial disorders of the vulva: squamous vulvar intraepithelial neoplasia, vulvar Paget's disease and melanoma in situ by Terlou, Annelinde, Blok, Leen J, Helmerhorst, Theo J M, van Beurden, Marc

“…No standard screening programs exist to detect vulvar carcinoma or its precursor lesions, and therefore gynecologists, dermatologists and other healthcare…”
Get more information

Chromosomal Signatures of a Subset of High-Grade Premalignant Cervical Lesions Closely Resemble Invasive Carcinomas by WILTING, Saskia M, STEENBERGEN, Renske D. M, YLSTRA, Bauke, MEIJER, Chris J. L. M, SNIJDERS, Peter J. F, TIJSSEN, Marianne, VAN WIERINGEN, Wessel N, HELMERHORST, Theo J. M, VAN KEMENADE, Folkert J, BLEEKER, Maaike C. G, VAN DE WIEL, Mark A, CARVALHO, Beatriz, MEIJER, Gerrit A

“…Cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (CIN) harboring a transforming infection with high-risk human…”
Get full text

Safety of extending screening intervals beyond five years in cervical screening programmes with testing for high risk human papillomavirus: 14 year follow-up of population based randomised cohort in the Netherlands by Dijkstra, Maaike G, van Zummeren, Marjolein, Rozendaal, Lawrence, van Kemenade, Folkert J, Helmerhorst, Theo J M, Snijders, Peter J F, Meijer, Chris J L M, Berkhof, Johannes

“…Objectives To provide an early risk assessment of extending screening intervals beyond five years for a human papillomavirus (HPV) based cervical screening…”
Get full text

Reduced local immunity in HPV‐related VIN: Expression of chemokines and involvement of immunocompetent cells by Santegoets, Lindy A.M., van Seters, Manon, Heijmans‐Antonissen, Claudia, KleinJan, Alex, van Beurden, Marc, Ewing, Patricia C., Kühne, Liesbeth C.M., Beckmann, Ilse, Burger, Curt W., Helmerhorst, Theo J.M., Blok, Leen J.

“…Usual type VIN is a premalignant disorder caused by persistent HPV infection. High prevalence of VIN in immuno‐suppressed women suggests that a good innate and…”
Get full text

Post‐treatment CIN: Randomised clinical trial using hrHPV testing for prediction of residual/recurrent disease by Bais, Aagje G., Eijkemans, Marinus J.C., Rebolj, Mateja, Snijders, Peter J.F., Verheijen, René H.M., van Ballegooijen, Marjolein, Meijer, Chris J.L.M., Helmerhorst, Theo J.M.

“…We investigated in a randomised clinical trial whether addition of hrHPV testing (high‐risk human papillomavirus) to cytological follow‐up after treatment for…”
Get full text