Search Results - "Helmerhorst, E.J."

Saliva and Serum Protein Exchange at the Tooth Enamel Surface by Heller, D., Helmerhorst, E.J., Oppenheim, F.G.

“…The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument…”
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Saliva: a Dynamic Proteome by Helmerhorst, E.J., Oppenheim, F.G.

“…The proteome of whole saliva, in contrast to that of serum, is highly susceptible to a variety of physiological and biochemical processes. First, salivary…”
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Whole-saliva Proteolysis and Its Impact on Salivary Diagnostics by Thomadaki, K., Helmerhorst, E.J., Tian, N., Sun, X., Siqueira, W.L., Walt, D.R., Oppenheim, F.G.

“…There is growing interest in the use of human whole saliva for diagnostics and disease monitoring as an alternative to blood samples. In contrast to blood,…”
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Identification of early microbial colonizers in human dental biofilm by Li, J., Helmerhorst, E.J., Leone, C.W., Troxler, R.F., Yaskell, T., Haffajee, A.D., Socransky, S.S., Oppenheim, F.G.

“…Aims:  To elucidate the first colonizers within in vivo dental biofilm and to establish potential population shifts that occur during the early phases of…”
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Proteome of Human Minor Salivary Gland Secretion by Siqueira, W.L., Salih, E., Wan, D.L., Helmerhorst, E.J., Oppenheim, F.G.

“…Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might…”
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Identification of in vivo Pellicle Constituents by Analysis of Serum Immune Responses by Li, J., Helmerhorst, E.J., Troxler, R.F., Oppenheim, F.G.

“…Human acquired enamel pellicle is composed of molecules that selectively adsorb from saliva onto tooth surfaces and provides a protective interface between the…”
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Salivary Analyte Profiles and Asthma Severity by Wexler, P.J, Siqueira, W.L, Helmerhorst, E.J, Oppenheim, F.G, Lomasky, R, Brodley, C.E, Hayman, R.B, Blicharz, T.M, Walt, D.R, Little, F.F

“…In the future, this profile will be correlated with asthma control and may be a tool to aid clinical asthma management…”
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Statherin is an in vivo pellicle constituent: identification and immuno-quantification by Li, J, Helmerhorst, E.J, Yao, Y, Nunn, M.E, Troxler, R.F, Oppenheim, F.G

“…Recently, we demonstrated that anti-statherin monoclonal antibodies could be generated upon immunisation of mice with in vivo formed human acquired enamel…”
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Salivary Cytokine amd Pathogen Detection in Patients with Asthma by Wexler, P.J, Little, F.F, Brody, J.S, Siqueira, W.L, Helmerhorst, E.J, Oppenheim, F.G, Bilcharz, T, Hayman, R, Walt, D.R

“…Salivary analysis of cytokines and pathogens could offer noninvasive rapid diagnostic information on contributors to asthma control deterioration…”
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The Effects of Histatin-derived Basic Antimicrobial Peptides on Oral Biofilms by Helmerhorst, E.J., Hodgson, R., van't Hof, W., Veerman, E.C.I., Allison, C., Nieuw Amerongen, A.v.

“…Susceptibility of bacteria to antimicrobial agents is strongly reduced by the formation of complex biofilms. We investigated whether synthetic histatin analogs…”
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The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity by Fernandez-Feo, M., Wei, G., Blumenkranz, G., Dewhirst, F.E., Schuppan, D., Oppenheim, F.G., Helmerhorst, E.J.

“…Coeliac disease is characterized by intestinal inflammation caused by gluten, proteins which are widely contained in the Western diet. Mammalian digestive…”
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Nanoscale Adhesion Forces between Enamel Pellicle Proteins and Hydroxyapatite by Vukosavljevic, D., Hutter, J.L., Helmerhorst, E.J., Xiao, Y., Custodio, W., Zaidan, F.C., Oppenheim, F.G., Siqueira, W.L.

“…The acquired enamel pellicle (AEP) is important for minimizing the abrasion caused by parafunctional conditions as they occur, for instance, during bruxism. It…”
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Evidence of Intact Histatins in the in vivo Acquired Enamel Pellicle by Siqueira, W.L., Margolis, H.C., Helmerhorst, E.J., Mendes, F.M., Oppenheim, F.G.

“…Understanding the composition and function of the acquired enamel pellicle (AEP) has been a major goal in oral biology. The aim of this study was to test the…”
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Oral fluid proteolytic effects on histatin 5 structure and function by Helmerhorst, E.J., Alagl, A.S., Siqueira, W.L., Oppenheim, F.G.

“…Histatins are human salivary antifungal proteins that are prone to extensive enzymatic degradation upon their release into the oral cavity. Histatin…”
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The Cellular Target of Histatin 5 on Candida albicans Is the Energized Mitochondrion by Helmerhorst, Eva J., Breeuwer, Pieter, van 't Hof, Wim, Walgreen-Weterings, Els, Oomen, Lauran C.J.M., Veerman, Enno C.I., Amerongen, Arie V. Nieuw, Abee, Tjakko

“…Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the…”
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Characterization of histatin 5 with respect to amphipathicity, hydrophobicity, and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation by Helmerhorst, Eva J., Van't Hof, Wim, Breeuwer, Pieter, Veerman, EnnoC.I., Abee, Tjakko, Troxler, Robert F., Amerongen, Arie V. Nieuw, Oppenheim, Frank G.

“…Histatin 5 is a 24-residue peptide from human saliva with antifungal properties. We recently demonstrated that histatin 5 translocates across the yeast…”
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