Search Results - "Helman, L"

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism by WAN, X, HARKAVY, B, SHEN, N, GROHAR, P, HELMAN, L. J

“…Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that…”
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Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis by Mirciov, Cornel S G, Wilkins, Sarah J, Hung, Grace C C, Helman, Sheridan L, Anderson, Gregory J, Frazer, David M

“…The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric…”
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The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease by Carolin, Agnes, Frazer, David, Yan, Kexin, Bishop, Cameron R, Tang, Bing, Nguyen, Wilson, Helman, Sheridan L, Horvat, Jay, Larcher, Thibaut, Rawle, Daniel J, Suhrbier, Andreas

“…The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of…”
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A Decrease in Maternal Iron Levels Is the Predominant Factor Suppressing Hepcidin during Pregnancy in Mice by Helman, Sheridan L, Wilkins, Sarah J, Chan, Jennifer C. J, Hartel, Gunter, Wallace, Daniel F, Anderson, Gregory J, Frazer, David M

“…In order to supply adequate iron during pregnancy, the levels of the iron regulatory hormone hepcidin in the maternal circulation are suppressed, thereby…”
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Pulmonary hypertension in advanced sarcoidosis: epidemiology and clinical characteristics by Shorr, A. F, Helman, D. L, Davies, D. B, Nathan, S. D

“…Pulmonary hypertension (PH) is a predictor of poor outcome in sarcoidosis. Little is known about the epidemiology of PH in sarcoidosis. The current authors…”
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Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma by Kang, Z, Yu, Y, Zhu, Y J, Davis, S, Walker, R, Meltzer, P S, Helman, L J, Cao, L

“…Agents targeting the insulin-like growth factor-1 receptor (IGF1R) are in clinical development, but, despite some initial success of single agents in sarcoma,…”
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Histone deacetylase inhibition triggers suppression of the IGF-1R/Akt pathway in rhabdomyosarcoma and Pax3-Foxo1 in alveolar rhabdomyosarcoma by Wan, X, Issak, S, Yeung, C, McCalla, A, Helman, L

“…An abstract of the study of Wan et. al. about histone deacetylase inhibition triggers suppression of the IGF-1R/Akt pathway in rhabdomyosarcoma and Pax3-Foxo1…”
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Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth by Yeung, C L, Ngo, V N, Grohar, P J, Arnaldez, F I, Asante, A, Wan, X, Khan, J, Hewitt, S M, Khanna, C, Staudt, L M, Helman, L J

“…To identify novel signaling pathways necessary for rhabdomyosarcoma (RMS) survival, we performed a loss-of-function screen using an inducible small hairpin RNA…”
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Outcomes and safety of surgical lung biopsy for interstitial lung disease by Lettieri, Christopher J, Veerappan, Ganesh R, Helman, Donald L, Mulligan, Charles R, Shorr, Andrew F

“…To determine the safety of surgical lung biopsy (SLB) in patients with interstitial lung disease (ILD), and specifically in those with idiopathic pulmonary…”
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Pneumatic dilation versus laparoscopic Heller myotomy for the treatment of achalasia: variables related to a good response by Borges, A. A., Lemme, E. M. de O., Abrahao Jr, L. J., Madureira, D., Andrade, M. S., Soldan, M., Helman, L.

“…Summary Achalasia is a motor disorder characterized by esophageal aperistalsis and failure of lower esophageal sphincter relaxation. The cardinal symptoms are…”
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Mechanisms of sarcoma development by Helman, Lee J, Meltzer, Paul

“…Sarcomas are a rare and diverse group of tumours that are derived from connective tissues, including bone, muscle and cartilage. Although there are instances…”
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Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x by Mayeenuddin, L H, Yu, Y, Kang, Z, Helman, L J, Cao, L

“…Insulin-like growth factors (IGFs) and their receptor, IGF-1 receptor (IGF1R), have important roles in growth, development, stress response, aging and cancer…”
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Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer by Schayek, H, Bentov, I, Jacob-Hirsch, J, Yeung, C, Khanna, C, Helman, L J, Plymate, S R, Werner, H

“…The insulin-like growth factor-I (IGF-IR) and androgen (AR) receptors are important players in prostate cancer. Functional interactions between the IGF-I and…”
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Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin by Wan, X, Kim, S Y, Guenther, L M, Mendoza, A, Briggs, J, Yeung, C, Currier, D, Zhang, H, Mackall, C, Li, W-J, Tuan, R S, Deyrup, A T, Khanna, C, Helman, L

“…The development of pulmonary metastasis is the major cause of death in osteosarcoma, and its molecular basis is poorly understood. In this study, we show that…”
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252 The DNA damage response gene Schlafen 11 (SLFN11) is a transcriptional target of ETS transcription factors in Ewing's sarcoma and other cancers by Pommier, Y, Bilke, S.W, Sousa, F, Yamade, M, Murai, J, Rajapakse, V, Helman, L, Meltzer, P

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Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-xL by Mayeenuddin, L H, Yu, Y, Kang, Z, Helman, L J, Cao, L

“…Insulin-like growth factors (IGFs) and their receptor, IGF-1 receptor (IGF1R), have important roles in growth, development, stress response, aging and cancer…”
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Effect of standardized orders and provider education on head-of-bed positioning in mechanically ventilated patients by Helman, Donald L, Sherner, John H, Fitzpatrick, Thomas M, Callender, Marcia E, Shorr, Andrew F

“…OBJECTIVESemirecumbent head-of-bed positioning in mechanically ventilated patients decreases the risk of developing ventilator-associated pneumonia (VAP). The…”
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Resistance training and gait function in Patients with Parkinson's disease by SCANDALIS, Thomas A, BOSAK, Andrew, BERLINER, Jeffery C, HELMAN, Laura L, WELLS, Michael R

“…To determine whether patients with Parkinson's disease who are enrolled in a resistance training program can gain strength similar to that of normal control…”
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Involvement of IGF-II in human cancer by Toretsky, J A, Helman, L J

“…IGF-II is a regulatory peptide which appears to be involved significantly in the progression of many tumors, while minimally involved in post-fetal non-tumor…”
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An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential by Khanna, C, Prehn, J, Yeung, C, Caylor, J, Tsokos, M, Helman, L

“…To provide an investigative tool for the study of osteosarcoma (OSA) biology we have developed a syngeneic (balb/c) murine model of OSA, using cell lines…”
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