Search Results - "Helman, J"

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism by WAN, X, HARKAVY, B, SHEN, N, GROHAR, P, HELMAN, L. J

“…Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that…”
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A progressive algorithm in maxillary reconstruction by Helman, J

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Medication related osteonecrosis of the jaw: University of Michigan experience by Helman, J

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Targeting cancer metabolism by Teicher, Beverly A, Linehan, W Marston, Helman, Lee J

“…The understanding that oncogenes can have profound effects on cellular metabolism and the discovery of mutations and alterations in several metabolism-related…”
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Seasonal variations in the dose-response relationship of acetylcholinesterase activity in freshwater fish exposed to chlorpyrifos and glyphosate by Bernal-Rey, Daissy L., Cantera, Cecilia G., dos Santos Afonso, Maria, Menéndez-Helman, Renata J.

“…The herbicide glyphosate [N- (phosphonomethyl) glycine; PMG] and the insecticide chlorpyrifos [O, O-diethyl O- (3,5,6-trichloro-2-pyridinyl) -phosphorothioate,…”
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Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1 by ROBBINS, Paul F, MORGAN, Richard A, KAMMULA, Udai S, HUGHES, Marybeth S, RESTIFO, Nicholas P, RAFFELD, Mark, LEE, Chyi-Chia Richard, LEVY, Catherine L, LI, Yong F, EL-GAMIL, Mona, SCHWARZ, Susan L, LAURENCOT, Carolyn, FELDMAN, Steven A, ROSENBERG, Steven A, YANG, James C, SHERRY, Richard M, DUDLEY, Mark E, WUNDERLICH, John R, NAHVI, Azam V, HELMAN, Lee J, MACKALL, Crystal L

“…Adoptive immunotherapy using tumor-infiltrating lymphocytes represents an effective cancer treatment for patients with metastatic melanoma. The NY-ESO-1…”
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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma by Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M

“…Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first…”
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Mechanisms of sarcoma development by Helman, Lee J, Meltzer, Paul

“…Sarcomas are a rare and diverse group of tumours that are derived from connective tissues, including bone, muscle and cartilage. Although there are instances…”
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SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma by Tang, Sai-Wen, Bilke, Sven, Cao, Liang, Murai, Junko, Sousa, Fabricio G, Yamade, Mihoko, Rajapakse, Vinodh, Varma, Sudhir, Helman, Lee J, Khan, Javed, Meltzer, Paul S, Pommier, Yves

“…SLFN11 was identified as a critical determinant of response to DNA-targeted therapies by analyzing gene expression and drug sensitivity of NCI-60 and CCLE…”
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R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study by PAPPO, Alberto S, PATEL, Shreyaskumar R, GANJOO, Kristen N, SCHUETZE, Scott M, JUERGENS, Heribert, LEAHY, Michael G, GEOERGER, Birgit, BENJAMIN, Robert S, HELMAN, Lee J, BAKER, Laurence H, CROWLEY, John, REINKE, Denise K, KUENKELE, Klaus-Peter, CHAWLA, Sant P, TONER, Guy C, MAKI, Robert G, MEYERS, Paul A, CHUGH, Rashmi

“…The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a…”
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Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma by Slemmons, Katherine K, Yeung, Choh, Baumgart, Joshua T, Juarez, Jhazeel O Martinez, McCalla, Amy, Helman, Lee J

“…Rhabdomyosarcoma is the most common childhood soft-tissue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a need…”
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Glyphosate input modifies microbial community structure in clear and turbid freshwater systems by Pizarro, H, Vera, M. S, Vinocur, A, Pérez, G, Ferraro, M, Menéndez Helman, R. J, dos Santos Afonso, M

“…Since it was commercially introduced in 1974, glyphosate has been one of the most commonly used herbicides in agriculture worldwide, and there is growing…”
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Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer by LIANG CAO, YUNKAI YU, BILKE, Sven, WALKER, Robert L, MAYEENUDDIN, Linnia H, AZORSA, David O, FAN YANG, PINEDA, Marbin, HELMAN, Lee J, MELTZER, Paul S

“…The PAX3-FKHR fusion protein is present in a majority of alveolar rhabdomyosarcomas associated with increased aggressiveness and poor prognosis. To better…”
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Effects of estradiol and ethinylestradiol on sperm quality, fertilization, and embryo–larval survival of pejerrey fish (Odontesthes bonariensis) by Gárriz, Ángela, Menéndez-Helman, Renata J., Miranda, Leandro A.

“…•Estrogenic compounds are present in surface waters as a consequence of sewage discharges.•Mixtures of E2 and EE2 affected pejerrey sperm motility and…”
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Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic by Weldon, Christopher B, Madenci, Arin L, Boikos, Sosipatros A, Janeway, Katherine A, George, Suzanne, von Mehren, Margaret, Pappo, Alberto S, Schiffman, Joshua D, Wright, Jennifer, Trent, Jonathan C, Pacak, Karel, Stratakis, Constantine A, Helman, Lee J, La Quaglia, Michael P

“…Purpose Wild-type gastrointestinal stromal tumors (WT-GISTs) that lack KIT or PDGFRA mutations represent a unique subtype of GIST that predominantly affects…”
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Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening by Grohar, Patrick J., Woldemichael, Girma M., Griffin, Laurie B., Mendoza, Arnulfo, Chen, Qing-Rong, Yeung, Choh, Currier, Duane G., Davis, Sean, Khanna, Chand, Khan, Javed, McMahon, James B., Helman, Lee J.

“…Background Chromosomal translocations generating oncogenic transcription factors are the hallmark of a variety of tumors, including many sarcomas. Ewing…”
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IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma by Wan, Xiaolin, Yeung, Choh, Heske, Christine, Mendoza, Arnulfo, Helman, Lee J

“…Abstract The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its fundamental roles in…”
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Prospects and challenges for the development of new therapies for Ewing sarcoma by GROHAR, Patrick J, HELMAN, Lee J

“…The Ewing sarcoma family of tumors or Ewing sarcoma (ES) is the second most common malignant bone tumor of childhood. The prognosis for localized Ewing sarcoma…”
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Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea by Paredes, María Gimena, Bianco, Karina Alesia, Menéndez-Helman, Renata J., Kristoff, Gisela

“…Lugano Lake is located in an Ecological Reserve of Buenos Aires City. Biomonitoring of its water quality is essential due to its importance as a place for…”
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Targeting the Insulin Growth Factor Receptor 1 by Arnaldez, Fernanda I., MD, Helman, Lee J., MD

“…The IGF axis is a tightly controlled endocrine system that regulates cell growth and development, known to have an important function in cancer biology. IGF1…”
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