Search Results - "Hellyer, Shane D"

Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment by Shajan, Britto, Bastiampillai, Tarun, Hellyer, Shane D., Nair, Pramod C.

“…For over seven decades, dopamine receptor 2 (D 2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective…”
Get full text

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations by Shajan, Britto, Marri, Shashikanth, Bastiampillai, Tarun, Gregory, Karen J, Hellyer, Shane D, Nair, Pramod C

“…Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric conditions. TAAR1…”
Get full text

SCA44‐ and SCAR13‐associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms by Wang, Yuyang, Muraleetharan, Ashwin, Langiu, Monica, Gregory, Karen J., Hellyer, Shane D.

“…Background and Purpose Metabotropic glutamate receptor 1 (mGlu1) is a promising therapeutic target for neurodegenerative CNS disorders including…”
Get full text

Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe- and Assay-Dependent Pharmacology by Muraleetharan, Ashwin, Wang, Yuyang, Rowe, Matthew C, Gould, Ashleigh, Gregory, Karen J, Hellyer, Shane D

“…Allosteric modulation of metabotropic glutamate receptor subtype 1 (mGlu ) represents a viable therapeutic target for treating numerous central nervous system…”
Get full text

Metabotropic glutamate receptor 5 (mGlu5)‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons by Hellyer, Shane D., Albold, Sabine, Sengmany, Kathy, Singh, Junaid, Leach, Katie, Gregory, Karen J.

“…Allosteric modulators of metabotropic glutamate receptor 5 (mGlu5) are a promising therapeutic strategy for a number of neurological disorders. Multiple…”
Get full text

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site by Hellyer, Shane D., Sengmany, Kathy, Keller, Andrew N., Christopoulos, Arthur, Leach, Katie, Gregory, Karen J.

“…[Display omitted] The metabotropic glutamate receptor 5 (mGlu5) is a promising therapeutic target for multiple CNS disorders. Recent mGlu5 drug discovery has…”
Get full text

Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism by Sengmany, Kathy, Hellyer, Shane D., Christopoulos, Arthur, Lapinsky, David J., Leach, Katie, Gregory, Karen J.

“…[Display omitted] Allosteric modulators of metabotropic glutamate receptor subtype 5 (mGlu5) represent an attractive therapeutic strategy for multiple CNS…”
Get full text

Metabotropic glutamate receptor 5 (mGlu 5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu 5 signaling in recombinant cells and neurons by Hellyer, Shane D, Albold, Sabine, Sengmany, Kathy, Singh, Junaid, Leach, Katie, Gregory, Karen J

“…Allosteric modulators of metabotropic glutamate receptor 5 (mGlu ) are a promising therapeutic strategy for a number of neurological disorders. Multiple mGlu…”
Get full text

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology by Sengmany, Kathy, Hellyer, Shane D., Albold, Sabine, Wang, Taide, Conn, P. Jeffrey, May, Lauren T., Christopoulos, Arthur, Leach, Katie, Gregory, Karen J.

“…Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5) have been proposed as potential therapies for various CNS disorders. These…”
Get full text

Adenosine receptor signalling in Alzheimer’s disease by Trinh, Phuc N. H., Baltos, Jo-Anne, Hellyer, Shane D., May, Lauren T., Gregory, Karen J.

“…Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better understanding…”
Get full text

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias by Arsova, Angela, Møller, Thor C, Hellyer, Shane D, Vedel, Line, Foster, Simon R, Hansen, Jakob L, Bräuner-Osborne, Hans, Gregory, Karen J

“…Positive allosteric modulation of metabotropic glutamate subtype 5 (mGlu ) receptor has emerged as a potential new therapeutic strategy for the treatment of…”
Get full text

Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease by Trinh, Phuc N. H., Baltos, Jo-Anne, Hellyer, Shane D., May, Lauren T., Gregory, Karen J.

Get full text

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5 by Chen, Amy N. Y., Hellyer, Shane D., Trinh, Phuc N. H., Leach, Katie, Gregory, Karen J.

“…Allosteric modulators bind sites distinct from orthosteric ligands, allowing for improved spatiotemporal control of receptors and greater subtype selectivity…”
Get full text

Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes by Hellyer, Shane D, Aggarwal, Shaili, Chen, Amy N Y, Leach, Katie, Lapinsky, David J, Gregory, Karen J

“…The metabotropic glutamate receptor 2 (mGlu ) is a transmembrane-spanning class C G protein-coupled receptor that is an attractive therapeutic target for…”
Get full text

Pinnatoxins E, F and G target multiple nicotinic receptor subtypes by Hellyer, Shane D., Indurthi, Dinesh, Balle, Thomas, Runder‐Varga, Vanda, Selwood, Andrew I., Tyndall, Joel D.A., Chebib, Mary, Rhodes, Lesley, Kerr, D. Steven

“…Pinnatoxins are members of the cyclic imine group of marine phycotoxins that are highly toxic in in vivo rodent bioassays, causing rapid death due to…”
Get full text

Neuromuscular blocking activity of pinnatoxins E, F and G by Hellyer, Shane D., Selwood, Andrew I., Rhodes, Lesley, Kerr, D. Steven

“…Pinnatoxins are produced by dinoflagellates and belong to the cyclic imine family of toxins. They are fast-acting and highly toxic when administered in vivo in…”
Get full text

Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation by Hellyer, Shane D., Selwood, Andrew I., Rhodes, Lesley, Kerr, D. Steven

“…Members of the cyclic imine group of toxins, gymnodimine and spirolides, have been found to be potent antagonists of both muscle type and neuronal nicotinic…”
Get full text

In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative by Hellyer, Shane D., Selwood, Andrew I., van Ginkel, Roel, Munday, Rex, Sheard, Phil, Miles, Christopher O., Rhodes, Lesley, Kerr, D. Steven

“…Fluorescent molecules are regularly utilised to study ligand–receptor interactions. Many ligands for nicotinic receptors have been conjugated with fluorophores…”
Get full text

T54. INVESTIGATING TRANSCRIPTOMIC PROFILE AND NEURITE OUTGROWTH IN ADHD USING INDUCED PLURIPOTENT STEM CELLS DIFFERENTIATED INTO DOPAMINE NEURONS by Namipashaki, Atefeh, Hellyer, Shane D., Arnatkeviciute, Aurina, Nowell, Cameron J., Walsh, Kevin, Gregory, Karen J., Polo, Jose M., Bellgrove, Mark A., Hawi, Ziarih

“…Attention deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental condition globally. It is characterized by inattention,…”
Get full text

Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators by Kos, Jackson A., Langiu, Monica, Hellyer, Shane D., Gregory, Karen J.

Get full text