Search Results - "Hellström, K. E."

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates by Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S., Casazza, A. M., Firestone, R. A., Hellström, I., Hellström, K. E.

“…Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an…”
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Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats by SJÖGREN, H. O, ISAKSSON, M, WILLNER, D, HELLSTRÖM, I, HELLSTRÖM, K. E, TRAIL, P. A

“…The internalizing monoclonal antibody BR96 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to DOX and a thioether…”
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Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma by McIntosh, M.W., Drescher, C., Karlan, B., Scholler, N., Urban, N., Hellstrom, K.E., Hellstrom, I.

“…The serum tumor marker CA 125 is elevated in most clinically advanced ovarian carcinomas. Because these elevations may precede clinical detection by a year or…”
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Enhanced Antitumor Activity of Paclitaxel in Combination with the Anticarcinoma Immunoconjugate BR96-Doxorubicin by TRAIL, P. A, WILLNER, D, BIANCHI, A. B, HENDERSON, A. J, TRAILSMITH, M. D, GIRIT, E, LASCH, S, HELLSTRÖM, I, HELLSTRÖM, K. E

“…The efficacy of chemotherapy has been improved by regimens that combine several cytotoxic drugs with different mechanisms of action and/or different…”
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Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4 by Chen, L, Ashe, S, Brady, W A, Hellström, I, Hellström, K E, Ledbetter, J A, McGowan, P, Linsley, P S

“…Interaction of the B7 molecule on antigen-presenting cells with its receptors CD28 and CTLA-4 on T cells provides costimulatory signals for T cell activation…”
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Primary Structure of the Human Melanoma-Associated Antigen p97 (Melanotransferrin) Deduced from the mRNA Sequence by Rose, Timothy M., Plowman, Gregory D., Teplow, David B., Dreyer, William J., Hellström, Karl Erik, Brown, Joseph P.

“…p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues. To determine the structure of…”
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Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models by Liu, Y, Tuve, S, Persson, J, Beyer, I, Yumul, R, Li, Z Y, Tragoolpua, K, Hellström, K-E, Roffler, S, Lieber, A

“…Tumor-associated antigens (TAAs) include overexpressed self-antigens (for example, Her2/neu ) and tumor virus antigens (for example, HPV-16 E6/E7). Although in…”
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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors by Melero, Ignacio, Shuford, Walter W, Newby, Stephanie Ashe, Aruffo, Alejandro, Ledbetter, Jeffrey A, Hellström, Karl Erik, Mittler, Robert S, Chen, Lieping

“…The 4-1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several…”
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Soluble Member(s) of the Mesothelin/Megakaryocyte Potentiating Factor Family are Detectable in Sera from Patients with Ovarian Carcinoma by Scholler, N, Fu, N, Yang, Y, Ye, Z, Goodman, G E, Hellström, K E, Hellström, I

“…mAb OV569 was made by immunizing mice with ovarian carcinoma cells. It binds to cells from ovarian carcinomas and, to a lesser extent, to cells from certain…”
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Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16 by Chen, L, Mizuno, MT, Singhal, MC, Hu, SL, Galloway, DA, Hellstrom, I, Hellstrom, KE

“…Human papillomavirus (HPV) type 16 has been implicated in the etiology of cervical carcinomas, but it is unknown whether HPV-specific immunity can function in…”
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Affinity maturation of the BR96 anti-carcinoma antibody by codon-based mutagenesis by Yelton, DE, Rosok, MJ, Cruz, G, Cosand, WL, Bajorath, J, Hellstrom, I, Hellstrom, KE, Huse, WD, Glaser, SM

“…We have increased up to 65-fold the avidity of BR96, a mAb recognizing Lewis Y (Le(y))-related Ags expressed on the surface of many human carcinomas. Libraries…”
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Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates by TRAIL, P. A, WILLNER, D, BRASLAWSKY, G. R, BROWN, J, HOFSTEAD, S. J, GREENFIELD, R. S, FIRESTONE, R. A, MOSURE, K, KADOW, K. F, YANG, M. B, HELLSTRÖM, K. E, HELLSTRÖM, I, KNIPE, J, HENDERSON, A. J, LASCH, S. J, ZOECKLER, M. E, TRAILSMITH, M. D, DOYLE, T. W, KING, H. D, CASAZZA, A. M

“…The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the…”
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Overexpression of HER-2 in ovarian carcinomas by HELLSTRÖM, Ingegerd, GOODMAN, Gary, PULLMAN, Janice, YI YANG, HELLSTRÖM, Karl Erik

“…The transmembrane receptor encoded by the HER-2 cellular oncogene is amplified in several types of human carcinomas and provides an attractive therapeutic…”
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In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats by Siegall, CB, Chace, D, Mixan, B, Garrigues, U, Wan, H, Paul, L, Wolff, E, Hellstrom, I, Hellstrom, KE

“…BR96 sFv-PE40 is a single-chain immunotoxin fusion protein targeted to the Ley Ag, which is expressed in many different human carcinomas as well as in normal…”
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Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity by LIEPING CHEN, MCGOWAN, P, ASHE, S, JOHNSTON, J, YIWEN LI, HELLSTRÖM, I, HELLSTRÖM, K. E

“…A costimulatory signal through B7 to its counter-receptor CD28 on T cells enhances T cell activation. We have generated recombinant retroviruses containing…”
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Amplification of tumor immunity by gene transfer of the co‐stimulatory 4‐1BB ligand: synergy with the CD28 co‐stimulatory pathway by Melero, Ignacio, Bach, Nathan, Hellström, Karl Erik, Aruffo, Alejandro, Mittler, Robert S., Chen, Lieping

“…We have explored the role of an activation‐induced T cell molecule, 4‐1BB (CDw137), in the amplification of tumor immunity by retrovirus‐mediated transduction…”
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Application of a filamentous phage pVIII fusion protein system suitable for efficient production, screening, and mutagenesis of F(ab) antibody fragments by Huse, WD, Stinchcombe, TJ, Glaser, SM, Starr, L, MacLean, M, Hellstrom, KE, Hellstrom, I, Yelton, DE

“…We describe the application of a novel filamentous phage vector system suitable for efficient screening and production of F(ab) antibody fragments. The vector…”
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Studies of a high molecular weight human melanoma-associated antigen by Hellstrom, I, Garrigues, HJ, Cabasco, L, Mosely, GH, Brown, JP, Hellstrom, KE

“…Hybridomas were generated by fusing SP2/0 mouse myeloma cells with spleen cells from mice that had been immunized with cultured human melanoma cells. One of…”
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Development and activities of the BR96-doxorubicin immunoconjugate by Hellström, I, Hellström, K E, Senter, P D

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Immunoconjugates and immunotoxins for therapy of solid tumors by HELLSTRÖM, I, TRAIL, P, SIEGALL, C, FIRESTONE, R, HELLSTRÖM, K. E

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