Search Results - "Hellner, Karin"

Human Papillomaviruses As Therapeutic Targets in Human Cancer by Hellner, Karin, Münger, Karl

“…Cervical carcinomas are almost universally associated with high-risk human papillomavirus (HPV) infections, and are a leading cause of cancer death in women…”
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Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation by Zheng, Yiyan, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Wang, Ming, Masuda, Kenta, Carrami, Eli M., Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Yau, Christopher, Jiang, Dahai, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Knapp, Stefan, Gray, Nathanael S., Campo, Leticia, Myers, Kevin A., Dhar, Sunanda, Ferguson, David, Bast, Robert C., Sood, Anil K., von Delft, Frank, Ahmed, Ahmed Ashour

“…Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the…”
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Recent advances in understanding and preventing human papillomavirus-related disease [version 1; peer review: 3 approved] by Hellner, Karin, Dorrell, Lucy

“…High-risk human papillomaviruses (hrHPV) are responsible for anogenital and oropharyngeal cancers, which together account for at least 5% of cancers worldwide…”
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Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation by Zheng, Yiyan, Sethi, Ritika, Mangala, Lingegowda S., Taylor, Charlotte, Goldsmith, Juliet, Wang, Ming, Masuda, Kenta, Carrami, Eli M., Mannion, David, Miranda, Fabrizio, Herrero-Gonzalez, Sandra, Hellner, Karin, Chen, Fiona, Alsaadi, Abdulkhaliq, Albukhari, Ashwag, Fotso, Donatien Chedom, Yau, Christopher, Jiang, Dahai, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Knapp, Stefan, Gray, Nathanael S., Campo, Leticia, Myers, Kevin A., Dhar, Sunanda, Ferguson, David, Bast, Robert C., Sood, Anil K., von Delft, Frank, Ahmed, Ahmed Ashour

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HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition by Hellner, Karin, Mar, Jessica, Fang, Frank, Quackenbush, John, Münger, Karl

“…Abstract Cancer-associated epithelial to mesenchymal transition (EMT) is crucial for invasion and metastasis. Molecular hallmarks of EMT include…”
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Viral perturbations of host networks reflect disease etiology by Gulbahce, Natali, Yan, Han, Dricot, Amélie, Padi, Megha, Byrdsong, Danielle, Franchi, Rachel, Lee, Deok-Sun, Rozenblatt-Rosen, Orit, Mar, Jessica C, Calderwood, Michael A, Baldwin, Amy, Zhao, Bo, Santhanam, Balaji, Braun, Pascal, Simonis, Nicolas, Huh, Kyung-Won, Hellner, Karin, Grace, Miranda, Chen, Alyce, Rubio, Renee, Marto, Jarrod A, Christakis, Nicholas A, Kieff, Elliott, Roth, Frederick P, Roecklein-Canfield, Jennifer, Decaprio, James A, Cusick, Michael E, Quackenbush, John, Hill, David E, Münger, Karl, Vidal, Marc, Barabási, Albert-László

“…Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated…”
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Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues by Rahmioglu, Nilufer, Drong, Alexander W, Lockstone, Helen, Tapmeier, Thomas, Hellner, Karin, Saare, Merli, Laisk-Podar, Triin, Dew, Christine, Tough, Emily, Nicholson, George, Peters, Maire, Morris, Andrew P, Lindgren, Cecilia M, Becker, Christian M, Zondervan, Krina T

“…Genome-wide association studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease…”
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Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 by Baldwin, Amy, Grueneberg, Dorre A., Hellner, Karin, Sawyer, Jacqueline, Grace, Miranda, Li, Wenliang, Harlow, Ed, Munger, Karl

“…Cervical carcinomas are initiated through a series of well-defined stages that rely on the expression of human papillomavirus (HPV) oncogenes. A panel of 100…”
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Elevated basophil count is associated with increased odds of endometriosis by Feng, Qian, Shigesi, Nina, Guan, Jun, Rahmioglu, Nilufer, Bafadhel, Mona, Paddon, Kevin, Hubbard, Carol, Zondervan, Krina T, Becker, Christian M, Hellner, Karin

“…Graphical abstract Abstract Immunological dysregulation plays a fundamental role in the inflammatory aspects of endometriosis. Circulating blood leukocytes,…”
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Novel canonical and non-canonical viral antigens extend current targets for immunotherapy of HPV-driven cervical cancer by Peng, Xu, Woodhouse, Isaac, Hancock, Gemma, Parker, Robert, Marx, Kristina, Müller, Julius, Salatino, Silvia, Partridge, Thomas, Nicastri, Annalisa, Liao, Hanqing, Kruppa, Gary, Hellner, Karin, Dorrell, Lucy, Ternette, Nicola

“…Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and…”
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Therapeutic HPV vaccines by Hancock, Gemma, Hellner, Karin, Dorrell, Lucy

“…High-risk human papillomavirus (HPV) infection is known to be a necessary factor for cervical and anogenital malignancies. Cervical cancers account for over a…”
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Prognostic characteristics, recurrence patterns, and survival outcomes of vulval squamous cell carcinoma – A twelve-year retrospective analysis of a tertiary centre by Darwish, Ahmed, Ismail, Lamiese, Manek, Sanjiv, Hellner, Karin, Kehoe, Sean, Soleymani majd, Hooman

“…Vulval cancer is a rare gynaecological malignancy. In this study, we present a tertiary centre case analysis to examine the recurrence patterns and survival…”
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Emergency hysterectomy following iatrogenic injury to the descending branch of the uterine artery during colposcopy by Soleymani Majd, Hooman, Yancheva, Slaveya, Abdul, Beena, Hellner, Karin

“…Large loop excision of the transformation zone is an extremely common procedure routinely carried out in a gynaecology or colposcopy outpatient setting under…”
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A multi-genotype therapeutic human papillomavirus vaccine elicits potent T cell responses to conserved regions of early proteins by Hancock, Gemma, Blight, Joshua, Lopez-Camacho, Cesar, Kopycinski, Jakub, Pocock, Mamatha, Byrne, Wendy, Price, Michael J., Kemlo, Phillip, Evans, Ranoromanana Ionitiana, Bloss, Angela, Saunders, Kathryn, Kirton, Richard, Andersson, Monique, Hellner, Karin, Reyes-Sandoval, Arturo, Dorrell, Lucy

“…Despite an efficacious prophylactic human papillomavirus (HPV) vaccine there is still a considerable global burden of HPV-related disease. Therapeutic vaccines…”
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An integrated single-cell reference atlas of the human endometrium by Marečková, Magda, Garcia-Alonso, Luz, Moullet, Marie, Lorenzi, Valentina, Petryszak, Robert, Sancho-Serra, Carmen, Oszlanczi, Agnes, Icoresi Mazzeo, Cecilia, Wong, Frederick C. K., Kelava, Iva, Hoffman, Sophie, Krassowski, Michał, Garbutt, Kurtis, Gaitskell, Kezia, Yancheva, Slaveya, Woon, Ee Von, Male, Victoria, Granne, Ingrid, Hellner, Karin, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Lotfollahi, Mohammad, Prigmore, Elena, Southcombe, Jennifer, Dragovic, Rebecca A., Becker, Christian M., Zondervan, Krina T., Vento-Tormo, Roser

“…The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors…”
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Elevated basophil count is associated with increased risk of endometriosis by Feng, Qian, Shigesi, Nina, Guan, Jun, Rahmioglu, Nilufer, Bafadhel, Mona, Paddon, Kevin, Hubbard, Carol, Zondervan, Krina, Becker, Christian, Hellner, Karin

“…Immunological dysregulation plays a fundamental role in the inflammatory aspects of endometriosis. Circulating blood leukocytes, one of the most abundant…”
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Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells by Taylor, Charlotte, Mannion, David, Miranda, Fabrizio, Karaminejadranjbar, Mohammad, Herrero-Gonzalez, Sandra, Hellner, Karin, Zheng, Yiyan, Bartholomeusz, Geoffrey, Bast, Jr, Robert C, Ahmed, Ahmed Ashour

“…Taxanes represent some of the most commonly used chemotherapeutic agents for ovarian cancer treatment. However, they are only effective in approximately 40% of…”
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Baseline characteristics and prevalence of HPV 6, 11, 16, 18 in young German women participating in phase III clinical trials of a quadrivalent HPV (6/11/16/18) vaccine by Barthell, Elisabeth, Woelber, Linn, Hellner, Karin, Camerer, Birka, Gieseking, Friederike, Hauschild, Maik, Mylonas, Ioannis, Friese, Klaus, Sings, Heather L., Railkar, Radha, Gause, Christine, Barr, Eliav

“…Introduction As limited data among German women exist about HPV, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae , we report the prevalence of these…”
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Angiotensin II and the Amygdala by ALBRECHT, DORIS, HELLNER, KARIN, WALTHER, THOMAS, VON BOHLEN UND HALBACH, OLIVER

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