Search Results - "Hellmich, Helen"

Principal component analysis of blood microRNA datasets facilitates diagnosis of diverse diseases by Sell, Stacy L, Widen, Steven G, Prough, Donald S, Hellmich, Helen L

“…Early, ideally pre-symptomatic, recognition of common diseases (e.g., heart disease, cancer, diabetes, Alzheimer's disease) facilitates early treatment or…”
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Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19 by Sell, Stacy L, Prough, Donald S, Weisz, Harris A, Widen, Steve G, Hellmich, Helen L

“…Many important questions remain regarding severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These…”
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Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line by Weisz, Harris A, Boone, Deborah R, Coggins, William S, Edwards, Gabrielle A, Willey, Hannah E, Widen, Steven G, Siegel, Dionicio, Nelson, Andrew T, Prough, Donald S, Hellmich, Helen L

“…Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort…”
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Traumatic brain injury-induced dysregulation of the circadian clock by Boone, Deborah R, Sell, Stacy L, Micci, Maria-Adelaide, Crookshanks, Jeanna M, Parsley, Margaret, Uchida, Tatsuo, Prough, Donald S, DeWitt, Douglas S, Hellmich, Helen L

“…Circadian rhythm disturbances are frequently reported in patients recovering from traumatic brain injury (TBI). Since circadian clock output is mediated by…”
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Traumatic brain injury induces long-lasting changes in immune and regenerative signaling by Boone, Deborah R, Weisz, Harris A, Willey, Hannah E, Torres, Karen E O, Falduto, Michael T, Sinha, Mala, Spratt, Heidi, Bolding, Ian J, Johnson, Kathea M, Parsley, Margaret A, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…There are no existing treatments for the long-term degenerative effects of traumatic brain injury (TBI). This is due, in part, to our limited understanding of…”
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Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury by Boone, Deborah R, Leek, Jeanna M, Falduto, Michael T, Torres, Karen E O, Sell, Stacy L, Parsley, Margaret A, Cowart, Jeremy C, Uchida, Tatsuo, Micci, Maria-Adelaide, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however,…”
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Clock Gene Expression in the Murine Gastrointestinal Tract: Endogenous Rhythmicity and Effects of a Feeding Regimen by Hoogerwerf, Willemijntje A, Hellmich, Helen L, Cornélissen, Germaine, Halberg, Franz, Shahinian, Vahakn B, Bostwick, Jonathon, Savidge, Tor C, Cassone, Vincent M

“…Background & Aims: Based on observations that the gastrointestinal tract is subject to various 24-hour rhythmic processes, it is conceivable that some of these…”
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MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries by Weisz, Harris A., Kennedy, Deborah, Widen, Steven, Spratt, Heidi, Sell, Stacy L., Bailey, Christine, Sheffield-Moore, Melinda, DeWitt, Douglas S., Prough, Donald S., Levin, Harvey, Robertson, Claudia, Hellmich, Helen L.

“…High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs…”
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MicroRNA profiling identifies a novel compound with antidepressant properties by Sell, Stacy L, Boone, Deborah R, Weisz, Harris A, Cardenas, Cesar, Willey, Hannah E, Bolding, Ian J, Micci, Maria-Adelaide, Falduto, Michael T, Torres, Karen E O, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…Patients with traumatic brain injury (TBI) are frequently diagnosed with depression. Together, these two leading causes of death and disability significantly…”
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Pathway-focused PCR array profiling of enriched populations of laser capture microdissected hippocampal cells after traumatic brain injury by Boone, Deborah R, Micci, Maria-Adelaide, Taglialatela, Isabella G, Hellmich, Judy L, Weisz, Harris A, Bi, Min, Prough, Donald S, DeWitt, Douglas S, Hellmich, Helen L

“…Cognitive deficits in survivors of traumatic brain injury (TBI) are associated with irreversible neurodegeneration in brain regions such as the hippocampus…”
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Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury by Hellmich, Helen L, Rojo, Daniel R, Micci, Maria-Adelaide, Sell, Stacy L, Boone, Deborah R, Crookshanks, Jeanna M, DeWitt, Douglas S, Masel, Brent E, Prough, Donald S

“…Developing new pharmacotherapies for traumatic brain injury (TBI) requires elucidation of the neuroprotective mechanisms of many structurally and functionally…”
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Laser Capture Microdissection in Traumatic Brain Injury Research: Obtaining Hippocampal Subregions and Pools of Injured Neurons for Genomic Analyses by Boone, Deborah R, Weisz, Harris A, Sell, Stacy L, Hellmich, Helen L

“…The methods presented here are based on our laboratory's 15 years of experience using laser capture microdissection to obtain samples for the study of gene…”
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Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury by Boone, Deborah Kennedy, Weisz, Harris A., Bi, Min, Falduto, Michael T., Torres, Karen E. O., Willey, Hannah E., Volsko, Christina M., Kumar, Anjali M., Micci, Maria-Adelaide, Dewitt, Douglas S., Prough, Donald S., Hellmich, Helen L.

“…The underlying molecular mechanisms of how dysregulated microRNAs (miRNAs) cause neurodegeneration after traumatic brain injury (TBI) remain elusive. Here we…”
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Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury by Rojo, Daniel R, Prough, Donald S, Falduto, Michael T, Boone, Deborah R, Micci, Maria-Adelaide, Kahrig, Kristen M, Crookshanks, Jeanna M, Jimenez, Arnaldo, Uchida, Tatsuo, Cowart, Jeremy C, Hawkins, Bridget E, Avila, Marcela, DeWitt, Douglas S, Hellmich, Helen L

“…Experimental evidence suggests that random, spontaneous (stochastic) fluctuations in gene expression have important biological consequences, including…”
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Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury by Weisz, Harris A, Boone, Deborah R, Sell, Stacy L, Hellmich, Helen L

“…The ability to isolate specific brain regions of interest can be impeded in tissue disassociation techniques that do not preserve their spatial distribution…”
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Publisher Correction: Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury by Boone, Deborah Kennedy, Weisz, Harris A., Bi, Min, Falduto, Michael T., Torres, Karen E. O., Willey, Hannah E., Volsko, Christina M., Kumar, Anjali M., Micci, Maria-Adelaide, Dewitt, Douglas S., Prough, Donald S., Hellmich, Helen L.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells by Yu, Guang-Xiang, Mueller, Martin, Hawkins, Bridget E, Mathew, Babu P, Parsley, Margaret A, Vergara, Leoncio A, Hellmich, Helen L, Prough, Donald S, Dewitt, Douglas S

“…Gap junctions (GJs) contribute to cerebral vasodilation, vasoconstriction, and, perhaps, to vascular compensatory mechanisms, such as autoregulation. To…”
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Laser capture microdissection of enriched populations of neurons or single neurons for gene expression analysis after traumatic brain injury by Boone, Deborah R, Sell, Stacy L, Hellmich, Helen Lee

“…Long-term cognitive disability after TBI is associated with injury-induced neurodegeneration in the hippocampus-a region in the medial temporal lobe that is…”
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Gastrin-Releasing Peptide Receptor in Breast Cancer Mediates Cellular Migration and Interleukin-8 Expression by Chao, Celia, M.D, Ives, Kirk, B.S, Hellmich, Helen L., Ph.D, Townsend, Courtney M., M.D, Hellmich, Mark R., Ph.D

“…Background Breast cancers aberrantly express gastrin-releasing peptide (GRP) hormone and its cognate receptor, gastrin-releasing peptide receptor (GRP-R)…”
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Effects of trauma, hemorrhage and resuscitation in aged rats by Hawkins, Bridget E, Cowart, Jeremy C, Parsley, Margaret A, Capra, Bridget A, Eidson, Kristine A, Hellmich, Helen L, DeWitt, Douglas S, Prough, Donald S

“…Abstract Traumatic brain injury (TBI) is a leading cause of death in the elderly and the incidence of mortality and morbidity increases with age. This study…”
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