Search Results - "Hellewell, P.G."

Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III by McGown, C.C., Brown, N.J., Hellewell, P.G., Reilly, C.S., Brookes, Z.L.S.

“…Sepsis induces microvascular inflammation and production of the vasodilator nitric oxide (NO) via endothelial and inducible nitric oxide synthase (eNOS or NOS…”
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Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea‐pig by Teixeira, M.M., Rossi, A.G., Williams, T.J., Hellewell, P.G.

“…1 Inflammation is central to the pathophysiology of asthma. The recent findings that different inflammatory cells may express different phosphodiesterase (PDE)…”
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Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure by Anker, S.D., Ponikowski, P.P., Clark, A.L., Leyva, F., Rauchhaus, M., Kemp, M., Teixeira, M.M., Hellewell, P.G., Hooper, J., Poole-Wilson, P.A., Coats, A.J.S.

“…Background Chronic heart failure is one of a number of disorders associated with the development of a wasting syndrome. The precise mechanisms of this remain…”
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Uric acid in chronic heart failure: a marker of chronic inflammation by Leyva, F., Anker, S.D., Godsland, I.F., Teixeira, M., Hellewell, P.G., Kox, W.J., Poole-Wilson, P.A., Coats, A.J.S.

“…Background Chronic heart failure is associated with hyperuricaemia and elevations in circulating markers of inflammation. Activation of xanthine oxidase,…”
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Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? by Teixeira, M.M., Gristwood, R.W., Cooper, N., Hellewell, P.G.

“…Phosphodiesterase type 4 (PDE4) plays a major role in modulating the activity of virtually all cells involved in the inflammatory process. Inhibitors of this…”
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Cytokine‐induced airway epithelial ICAM‐1 upregulation: quantification by high‐resolution scanning and transmission electron microscopy by Zhu, J., Rogers, A.V., Burke‐Gaffney, A, Hellewell, P.g, Jeffery, P.k

“…The aim of this study was to investigate the variation of intercellular adhesion molecule (ICAM)‐1 which occurs between individual airway epithelial cells of…”
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Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo by Williams, T.J., Hellewell, P.G.

“…The presence of eosinophils and their products in tissues is frequently associated with the pathogenesis of allergic inflammation. A better understanding of…”
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Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea‐pig skin by Teixeira, M.M., Williams, T.J., Hellewell, P.G.

“…1 Oedema formation in skin is dependent on a synergism between mediators that increase vascular permeability and mediators that enhance local blood flow…”
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Adhesion Molecule Strategies by Hellewell, P.G.

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Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin by Teixeira, M.M., Hellewell, P.G.

“…1 Heparin is widely used in the treatment of thrombotic disorders and as an aid in surgery. Antiinflammatory effects of heparin have also been described. In…”
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E‐type prostaglandins enhance local oedema formation and neutrophil accumulation but suppress eosinophil accumulation in guinea‐pig skin by Teixeira, M.M., Williams, T.J., Hellewell, P.G.

“…1 Prostaglandins possess both pro‐ and anti‐inflammatory actions depending on their route of administration and the experimental model used. In this study, we…”
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Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea‐pig skin by Teixeira, M.M., Reynia, S., Robinson, M., Shock, A., Williams, T.J., Williams, F.M., Rossi, A.G., Hellewell, P.G.

“…1 Intradermal injection of the complement fragment C5a des Arg induces local oedema formation that, in rabbits and man, is dependent on circulating…”
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Effects of agents which elevate cyclic AMP on guinea‐pig eosinophil homotypic aggregation by Teixeira, M.M., Rossi, A.G., Giembycz, M.A., Hellewell, P.G.

“…1 Eosinophil recruitment and activation in inflamed tissue is thought to play an important role in the pathophysiology of allergic diseases. Experimental…”
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Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea‐pig by Teixeira, M.M., Williams, T.J., Hellewell, P.G.

“…1 Eosinophils are thought to play an important role in the pathophysiology of allergic diseases and pharmacological suppression of their recruitment is…”
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Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised brown-Norway rats by Sun, J, Elwood, W, Haczku, A, Barnes, P J, Hellewell, P G, Chung, K F

“…We investigated the potential role of intercellular-adhesion molecule-1 (ICAM-1) in allergen-induced bronchial hyperresponsiveness (BHR) and inflammation in…”
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EFFECT OF SULPHASALAZINE ON PULMONARY INACTIVATION OF PROSTAGLANDIN F 2α IN THE PIG by HELLEWELL, P.G., PEARSON, J.D.

“…The metabolism of prostaglandin F 2α (PGF 2α ) 15 nM in 100,000 g supernatant fractions from piglet lung homogenates was inhibited by sulphasalazine with an IC…”
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Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea‐pig skin: contribution of neutrophils and endogenous mediators by Teixeira, M.M., Fairbairn, S.M., Norman, K.E., Williams, T.J., Rossi, A.G., Hellewell, P.G.

“…1 Mediators of inflammation can increase vascular permeability in at least two different ways: by acting directly on endothelial cells or, indirectly, through…”
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Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung by Seale, J.P., Nourshargh, S., Hellewell, P.G., Williams, T.J.

“…1 Rabbit isolated lungs were perfused via the pulmonary artery with Tyrode solution containing 4.5% Ficoll and 0.1% bovine serum albumin at a constant rate of…”
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A Comparison Of The Inhibitory Activity Of Selective PDE4 Inhibitors On Eosinophil Recruitment In Guinea Pig Skin by Teixeira, Mauro M, Miotla, J.M, Cooper, N, Gristwood, R.W, Hellewell, P.G

“…The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment…”
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Accumulation of sup 111 In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen by Nourshargh, S., Rampart, M., Hellewell, P.G., Jose, P.J., Harlan, J.M., Edwards, A.J., Williams, T.J.

“…The mAb 60.3 recognizes the neutrophil CD18 Ag. We have investigated the effect of in vitro pretreatment of radiolabeled neutrophils with mAb 60.3 on their…”
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