Search Results - "Hellesøy, Monica"

Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis by Hellesøy, Monica, Lorens, James B

“…The formation of new blood vessels by sprouting angiogenesis is tightly regulated by contextual cues that affect angiogeneic growth factor signaling. Both…”
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FLT3‐ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation by Engen, Caroline, Hellesøy, Monica, Grob, Tim, Al Hinai, Adil, Brendehaug, Atle, Wergeland, Line, Bedringaas, Siv Lise, Hovland, Randi, Valk, Peter J. M., Gjertsen, Bjørn T.

“…Recurrent somatic internal tandem duplications (ITD) in the FMS‐like tyrosine kinase 3 (FLT3) gene characterise approximately one third of patients with acute…”
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Single Cell Detection of the p53 Protein by Mass Cytometry by Fagerholt, Oda Helen Eck, Hellesøy, Monica, Gullaksen, Stein-Erik, Gjertsen, Bjørn Tore

“…The p53 protein and its post-translational modifications are distinctly expressed in various normal cell types and malignant cells and are usually detected by…”
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Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia by Tislevoll, Benedicte Sjo, Hellesøy, Monica, Fagerholt, Oda Helen Eck, Gullaksen, Stein-Erik, Srivastava, Aashish, Birkeland, Even, Kleftogiannis, Dimitrios, Ayuda-Durán, Pilar, Piechaczyk, Laure, Tadele, Dagim Shiferaw, Skavland, Jørn, Baliakas, Panagotis, Hovland, Randi, Andresen, Vibeke, Seternes, Ole Morten, Tvedt, Tor Henrik Anderson, Aghaeepour, Nima, Gavasso, Sonia, Porkka, Kimmo, Jonassen, Inge, Fløisand, Yngvar, Enserink, Jorrit, Blaser, Nello, Gjertsen, Bjørn Tore

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Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry by Kleftogiannis, Dimitrios, Gavasso, Sonia, Tislevoll, Benedicte Sjo, van der Meer, Nisha, Motzfeldt, Inga K.F., Hellesøy, Monica, Gullaksen, Stein-Erik, Griessinger, Emmanuel, Fagerholt, Oda, Lenartova, Andrea, Fløisand, Yngvar, Schuringa, Jan Jacob, Gjertsen, Bjørn Tore, Jonassen, Inge

“…Mass cytometry by time-of-flight (CyTOF) is an emerging technology allowing for in-depth characterization of cellular heterogeneity in cancer and other…”
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P409: BCL‐2/BCL‐XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53‐MUTATED ACUTE MYELOID LEUKEMIA by Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein‐Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika

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Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis by Hellesøy, Monica, Blois, Anna L, Tiron, Crina E, Mannelqvist, Monica, Akslen, Lars A, Lorens, James B

“…Akt kinase is a central signal transduction node that integrates extracellular cues that regulate cell migratory, proliferative, and morphological functions…”
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Early response evaluation by single cell signaling profiling in acute myeloid leukemia by Tislevoll, Benedicte Sjo, Hellesøy, Monica, Fagerholt, Oda Helen Eck, Gullaksen, Stein-Erik, Srivastava, Aashish, Birkeland, Even, Kleftogiannis, Dimitrios, Ayuda-Durán, Pilar, Piechaczyk, Laure, Tadele, Dagim Shiferaw, Skavland, Jørn, Baliakas, Panagotis, Hovland, Randi, Andresen, Vibeke, Seternes, Ole Morten, Tvedt, Tor Henrik Anderson, Aghaeepour, Nima, Gavasso, Sonia, Porkka, Kimmo, Jonassen, Inge, Fløisand, Yngvar, Enserink, Jorrit, Blaser, Nello, Gjertsen, Bjørn Tore

“…Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial…”
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Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia by Malani, Disha, Kumar, Ashwini, Brück, Oscar, Kontro, Mika, Yadav, Bhagwan, Hellesøy, Monica, Kuusanmäki, Heikki, Dufva, Olli, Kankainen, Matti, Eldfors, Samuli, Potdar, Swapnil, Saarela, Jani, Turunen, Laura, Parsons, Alun, Västrik, Imre, Kivinen, Katja, Saarela, Janna, Räty, Riikka, Lehto, Minna, Wolf, Maija, Gjertsen, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A, Kallioniemi, Olli, Porkka, Kimmo

“…We generated drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A…”
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Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis by Hellesøy, Monica, Engen, Caroline, Grob, Tim, Löwenberg, Bob, Valk, Peter J. M., Gjertsen, Bjørn T.

“…Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling…”
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AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells by Lotsberg, Maria L, Wnuk-Lipinska, Katarzyna, Terry, Stéphane, Tan, Tuan Zea, Lu, Ning, Trachsel-Moncho, Laura, Røsland, Gro V, Siraji, Muntequa I, Hellesøy, Monica, Rayford, Austin, Jacobsen, Kirstine, Ditzel, Henrik J, Vintermyr, Olav K, Bivona, Trever G, Minna, John, Brekken, Rolf A, Baguley, Bruce, Micklem, David, Akslen, Lars A, Gausdal, Gro, Simonsen, Anne, Thiery, Jean Paul, Chouaib, Salem, Lorens, James B, Engelsen, Agnete Svendsen Tenfjord

“…Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell…”
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Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types by Majumder, Muntasir M, Leppä, Aino-Maija, Hellesøy, Monica, Dowling, Paul, Malyutina, Alina, Kopperud, Reidun, Bazou, Despina, Andersson, Emma, Parsons, Alun, Tang, Jing, Kallioniemi, Olli, Mustjoki, Satu, O'Gorman, Peter, Wennerberg, Krister, Porkka, Kimmo, Gjertsen, Bjørn T, Heckman, Caroline A

“…Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the…”
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Preclinical characterisation and development of a novel myelodysplastic syndrome‐derived cell line by Shafiee, Sahba, Gelebart, Pascal, Popa, Mihaela, Hellesøy, Monica, Hovland, Randi, Brendsdal Forthun, Rakel, Lee, Jungwoo, Tohyama, Kaoru, Molven, Anders, Parekkadan, Biju, Tore Gjertsen, Bjørn, Olsnes Kittang, Astrid, McCormack, Emmet

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Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia by Forthun, Rakel Brendsdal, Hellesøy, Monica, Sulen, André, Kopperud, Reidun Kristin, Sjøholt, Gry, Bruserud, Øystein, McCormack, Emmet, Gjertsen, Bjørn Tore

“…Purpose Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we…”
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Titrating Complex Mass Cytometry Panels by Gullaksen, Stein‐Erik, Bader, Lucius, Hellesøy, Monica, Sulen, André, Fagerholt, Oda Helen Eck, Engen, Caroline B., Skavland, Jørn, Gjertsen, Bjørn Tore, Gavasso, Sonia

“…We describe here a simple and efficient antibody titration approach for cell‐surface markers and intracellular cell signaling targets for mass cytometry. The…”
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Early response evaluation in AML using mass cytometry by Gjertsen, Bjørn T., Tislevoll, Benedicte S., Fagerholt, Oda H.E., Hellesøy, Monica

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Targeting Venetoclax Resistance in TP53-Mutated Acute Myeloid Leukemia by Vänttinen, Ida, Ruokoranta, Tanja, Saad, Joseph J, Kytölä, Sari, Hellesøy, Monica, Gullaksen, Stein-Erik, Ettala, Pia-Sofia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Wennerberg, Krister, Gjertsen, Bjorn T., Heckman, Caroline A., Kontro, Mika, Kuusanmäki, Heikki

“…Introduction: The combination therapy of Venetoclax (Ven) and Azacitidine (Aza) has shown remarkable improvements in the treatment of acute myeloid leukemia…”
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Efficient in vivo vascularization of tissue-engineering scaffolds by Hegen, Anja, Blois, Anna, Tiron, Crina E., Hellesøy, Monica, Micklem, David R., Nör, Jacques E., Akslen, Lars A., Lorens, James B.

“…The success of tissue engineering depends on the rapid and efficient formation of a functional blood vasculature. Adult blood vessels comprise endothelial…”
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Early response evaluation by single cell signaling profiling in acute myeloid leukemia by Tislevoll, Benedicte Sjo, Hellesøy, Monica, Fagerholt, Oda Helen Eck, Gullaksen, Stein-Erik, Srivastava, Aashish, Birkeland, Even, Kleftogiannis, Dimitrios, Ayuda Duran, Pilar, Piechaczyk, Laure Isabelle, Tadele, Dagim Shiferaw, Skavland, Jørn, Panagiotis, Baliakas, Hovland, Randi, Andresen, Vibeke, Seternes, Ole Morten, Tvedt, Tor Henrik Anderson, Aghaeepour, Nima, Gavasso, Sonia, Porkka, Kimmo, Jonassen, Inge, Fløisand, Yngvar, Enserink, Jorrit, Blaser, Nello, Gjertsen, Bjørn Tore

“…Abstract Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate…”
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Bemcentinib (Oral AXL Inhibitor) in Combination with Low-Dose Cytarabine Is Well Tolerated and Efficacious in Older Relapsed AML Patients.Updates from the Ongoing Phase II Trial (NCT02488408) and Preliminary Translational Results Indicating Bemcentinib Elicits Anti-AML Immune Responses by Loges, Sonja, Sutamtewagul, Grerk, Heuser, Michael, Chromik, Jörg, Kapp-Schwoerer, Silke, Crugnola, Monica, Di Renzo, Nicola, Lemoli, Roberto M., Mattei, Daniele Giovanni, Ben Batalla, Isabel, Hellesøy, Monica, Waizenegger, Jonas, Janning, Melanie, Imbusch, Charles D., Beumer, Niklas, Rayford, Austin, Nautiyal, Jaya, Berkman-Gottlieb, Tzivia, Micklem, David, Gabra, Hani, Gorcea-Carson, Claudia, Lorens, James B., Fiedler, Walter, Alvarado, Yesid, Gjertsen, Bjorn T., Rieckmann, Lisa-Marie

“…Background: Relapsed (REL) & refractory (REF) r/r AML pts unsuitable for intensive therapy (IT) due to age or co-morbidities, have limited treatment options…”
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