Search Results - "Heller, Renu"

Global expression profiling of fibroblast responses to transforming growth factor-β1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching by CHAMBERS, Rachel C, LEONI, Patricia, KAMINSKI, Naftali, LAURENT, Geoffrey J, HELLER, Renu A

“…Transforming growth factor-β 1 (TGF-β 1 ) plays a central role in promoting extracellular matrix protein deposition by promoting the transformation of…”
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Gene Expression Analysis Reveals Matrilysin as a Key Regulator of Pulmonary Fibrosis in Mice and Humans by Zuo, Fengrong, Kaminski, Naftali, Eugui, Elsie, Allard, John, Yakhini, Zohar, Ben-Dor, Amir, Lollini, Lance, Morris, David, Kim, Yong, DeLustro, Barbara, Sheppard, Dean, Pardo, Annie, Selman, Moises, Heller, Renu A.

“…Pulmonary fibrosis is a progressive and largely untreatable group of disorders that affects up to 100,000 people on any given day in the United States. To…”
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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis by Heller, Renu, Steinman, Lawrence, Lock, Christopher, Hermans, Guy, Pedotti, Rosetta, Brendolan, Andrea, Schadt, Eric, Garren, Hideki, Langer-Gould, Annette, Strober, Samuel, Cannella, Barbara, Allard, John, Klonowski, Paul, Austin, Angela, Lad, Nagin, Kaminski, Naftali, Galli, Stephen J, Oksenberg, Jorge R, Raine, Cedric S

“…Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed increased transcripts of genes encoding inflammatory cytokines,…”
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The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease by Chabas, Dorothée, Baranzini, Sergio E., Mitchell, Dennis, Claude C. A. Bernard, Rittling, Susan R., Denhardt, David T., Sobel, Raymond A., Lock, Christopher, Karpuj, Marcela, Pedotti, Rosetta, Heller, Renu, Oksenberg, Jorge R., Steinman, Lawrence

“…Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing…”
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Microarrays: biotechnology's discovery platform for functional genomics by Schena, Mark, Heller, Renu A, Theriault, Thomas P, Konrad, Ken, Lachenmeier, Eric, Davis, Ronald W

“…Advances in microarray technology enable massive parallel mining of biological data, with biological chips providing hybridization-based expression monitoring,…”
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Discovery and Analysis of Inflammatory Disease-Related Genes Using cDNA Microarrays by Heller, Renu A., Schena, Mark, Chai, Andrew, Shalon, Dari, Bedilion, Tod, Gilmore, James, Woolley, David E., Davis, Ronald W.

“…cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. In inflammatory disease such as rheumatoid arthritis,…”
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Tumor Necrosis Factor Receptor-Mediated Signaling Pathways by Heller, Renu A., Krönke, Martin

“…Tumor necrosis factor (TNF) is discussed, focusing on the signaling pathways activated by two cell surface receptors and how they might interact to produce the…”
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Global Analysis of Gene Expression in Pulmonary Fibrosis Reveals Distinct Programs Regulating Lung Inflammation and Fibrosis by Kaminski, Naftali, Allard, John D., Pittet, Jean F., Zuo, Fengrong, Mark J.D. Griffiths, Morris, David, Huang, Xiaozhu, Sheppard, Dean, Heller, Renu A.

“…The molecular mechanisms of pulmonary fibrosis are poorly understood. We have used oligonucleotide arrays to analyze the gene expression programs that underlie…”
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Gene microarray analysis of multiple sclerosis lesions by Lock, Christopher B, Heller, Renu A

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Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases by Borden, P, Heller, R A

“…Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a…”
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Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans by Kaminski, Naftali, Zuo, Fengrong, Cojocaro, Gady, Yakhini, Zohar, Ben-Dor, Amir, Morris, David, Sheppard, Dean, Pardo, Annie, Selman, Moises, Heller, Renu A

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Cytokine Control of Interstitial Collagenase and Collagenase-3 Gene Expression in Human Chondrocytes by Borden, P, Solymar, D, Sucharczuk, A, Lindman, B, Cannon, P, Heller, R A

“…Human collagenase-3 expression, previously seen only in a breast tumor tissue, is here shown to be expressed in primary human chondrocytes derived from the…”
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Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cells by ROVELLI, G, HELLER, R. A, CANOSSA, M, SHOOTER, E. M

“…To elucidate the function of the two nerve growth factor (NGF) receptors, p75NGFR and p140trk, chimeric molecules were constructed of tumor necrosis factor…”
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Parallel Human Genome Analysis: Microarray-Based Expression Monitoring of 1000 Genes by Schena, Mark, Shalon, Dari, Heller, Renu, Chai, Andrew, Brown, Patrick O., Davis, Ronald W.

“…Microarrays containing 1046 human cDNAs of unknown sequence were printed on glass with high-speed robotics. These 1.0-cm$^{2}$ DNA ``chips'' were used to…”
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Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice by Hyman, R W, Frank, S, Warden, C H, Daluiski, A, Heller, R, Lusis, A J

“…Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the…”
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Distinct gene expression profiles of human type 1 and type 2 T helper cells by Hamalainen, H, Zhou, H, Chou, W, Hashizume, H, Heller, R, Lahesmaa, R

“…The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in…”
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Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation by Haridas, V, Darnay, B G, Natarajan, K, Heller, R, Aggarwal, B B

“…Because they have distinct intracellular domains, it has been proposed that the p60 and p80 forms of the TNF receptor mediate different signals. Several…”
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Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes by Borden, Paula, Solymar, Deborah, Sucharczuk, Anita, Lindman, Brian, Cannon, Paul, Heller, Renu A.

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Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis by HOECK, W. G, RAMESHA, C. S, CHANG, D. J, FAN, N, HELLER, R. A

“…The interaction of tumor necrosis factor alpha (TNF) with its two membrane-bound receptors initiates intracellular events in which arachidonic acid and its…”
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Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching by Chambers, Rachel C, Leoni, Patricia, Kaminski, Naftali, Laurent, Geoffrey J, Heller, Renu A

“…Transforming growth factor-beta1 (TGF-beta1) plays a central role in promoting extracellular matrix protein deposition by promoting the transformation of…”
Get full text