Search Results - "Heller, Jorge"

Poly(ortho esters): synthesis, characterization, properties and uses by Heller, Jorge, Barr, John, Ng, Steven Y, Abdellauoi, Khadija Schwach, Gurny, Robert

“…Over the last 30 years, poly(ortho esters) have evolved through four families, designated as POE I, POE II, POE III and POE IV. Of these, only POE IV has been…”
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Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines by Heller, Jorge, Langer, Robert, Wang, Chun, Ge, Qing, Ting, David, Nguyen, David, Shen, Hui-Rong, Chen, Jianzhu, Eisen, Herman N, Putnam, David

“…Genetic vaccination using plasmid DNA presents a unique opportunity for achieving potent immune responses without the potential limitations of many…”
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Patient-friendly bioerodible drug delivery systems by Heller, Jorge

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Ocular delivery using poly(ortho esters) by Heller, Jorge

“…Three families of poly(ortho esters) were investigated as a means of delivering 5-fluorouracil (5-FU), an antiproliferative agent used as an adjunct to…”
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Poly(ortho esters)From Concept to Reality by Heller, Jorge, Barr, John

“…The development of poly(ortho esters) dates back to the early 1970s, and during that time, four distinct families were developed. These polymers can be…”
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Polyacetal and poly(ortho ester)–poly(ethylene glycol) graft copolymer thermogels: Preparation, hydrolysis and FITC-BSA release studies by Schacht, Etienne, Toncheva, Veska, Vandertaelen, Kristin, Heller, Jorge

“…Graft copolymers comprised of a polyacetal backbone with pendant poly(ethylene glycol) side-chains were prepared using a condensation reaction between a…”
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Polyacetal−Doxorubicin Conjugates Designed for pH-Dependent Degradation by Tomlinson, Ryan, Heller, Jorge, Brocchini, Steve, Duncan, Ruth

“…Terpolymerization of poly(ethylene glycol) (PEG), divinyl ethers, and serinol can be used to synthesize water soluble, hydrolytically labile, amino-pendent…”
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Ocular delivery using poly(ortho esters): Drug delivery strategies to treat age-related macular degeneration by HELLER, Jorge

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Editorial by Heller, Jorge

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Editorial by Heller, Jorge

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Poly(Ortho Esters): Recent Developments for Biomedical Applications by Suzanne Einmahl, Khadija Schwach-Abdellaoui, Jorge Heller, Robert Gurny

“…Poly(ortho esters) (POE) are hydrophobic and bioerodible polymers that have been under development since the early 1970s. Up to now, four generations of such…”
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Joseph R. Robinson by Heller, Jorge, Park, Kinam

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Pendent Chain Functionalized Polyacetals That Display pH-Dependent Degradation:  A Platform for the Development of Novel Polymer Therapeutics by Tomlinson, Ryan, Klee, Marcus, Garrett, Shane, Heller, Jorge, Duncan, Ruth, Brocchini, Steve

“…The synthetic polymers that are used to prepare polymer therapeutics reaching clinical use are predominantly nonbiodegradable, and this severely limits the…”
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Double walled POE/PLGA microspheres: encapsulation of water-soluble and water-insoluble proteins and their release properties by Shi, Meng, Yang, Yi-Yan, Chaw, Cheng-Shu, Goh, Suat-Hong, Moochhala, Shabbir M., Ng, Steve, Heller, Jorge

“…The poly(orthoester) (POE)–poly( d,l-lactide–co-glycolide) (50:50) (PLGA) double-walled microspheres with 50% POE in weight were loaded with hydrophilic bovine…”
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Biochronomer technology by Heller, Jorge, Barr, John

“…Biochronomer (AP Pharma) is a fourth-generation poly(ortho ester) prepared by the condensation of diols and a diketene acetal. The polymer contains a…”
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Editorial by Heller, Jorge

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Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres by Liu, Lin-Shu, Liu, Shu-Qin, Ng, Steven Y, Froix, Michael, Ohno, Tadao, Heller, Jorge

“…Porous microspheres were formed by the gelation of two polysaccharides, a polyanionic sodium alginate and a polycationic chitosan, followed by lyophilization…”
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Recent developments with biodegradable polymers by DOMB, Abraham J, HELLER, Jorge

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POE/PLGA composite microspheres: formation and in vitro behavior of double walled microspheres by Yang, Yi-Yan, Shi, Meng, Goh, Suat-Hong, Moochhala, Shabbir M, Ng, Steve, Heller, Jorge

“…The poly(ortho ester) (POE) and poly(d,l-lactide-co-glycolide) 50:50 (PLGA) composite microspheres were fabricated by a water-in-oil-in-water (w/o/w) double…”
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Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone by Daniels, A U, Chang, M K, Andriano, K P

“…The mechanical properties of biodegradable polymers and composites proposed for use in internal fixation (in place of stainless steel) are crucial to the…”
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