Search Results - "Heller, James H."

Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17 by Kishnani, Priya S., Heller, James H., Spiridigliozzi, Gail A., Lott, Ira, Escobar, Luis, Richardson, Sharon, Zhang, Richard, McRae, Thomas

“…The objective of this 10‐week, randomized, double‐blind, placebo‐controlled multicenter study was to assess the efficacy and safety of donepezil for the…”
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Adaptive behavior in adolescents and adults with Down syndrome: Results from a 6‐month longitudinal study by Spiridigliozzi, Gail A., Goeldner, Celia, Edgin, Jamie, Hart, Sarah J., Noeldeke, Jana, Squassante, Lisa, Visootsak, Jeannie, Heller, James H., Khwaja, Omar, Kishnani, Priya S., Liogier d'Ardhuy, Xavier

“…Measures of adaptive behavior are important in the assessment and treatment of individuals with intellectual disabilities (ID). The purpose of the current…”
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Safety and efficacy of rivastigmine in children with Down syndrome: A double blind placebo controlled trial by Spiridigliozzi, Gail A., Hart, Sarah J., Heller, James H., Schneider, Heather E., Baker, Jane Ann, Weadon, Cathleen, Capone, George T., Kishnani, Priya S.

“…Individuals with Down syndrome (DS) have decreased cholinergic function and an uneven profile of cognitive abilities, with more pronounced deficits in…”
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Oropharyngeal Dysphagia in Infants and Children with Infantile Pompe Disease by Jones, Harrison N., Muller, Carolyn W., Lin, Min, Banugaria, Suhrad G., Case, Laura E., Li, Jennifer S., O’Grady, Gwendolyn, Heller, James H., Kishnani, Priya S.

“…Pompe disease is a rare genetic progressive neuromuscular disorder. The most severe form, infantile Pompe disease, has historically resulted in early…”
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Cognitive and adaptive functioning of children with infantile Pompe disease treated with enzyme replacement therapy: Long-term follow-up by Spiridigliozzi, Gail A., Heller, James H., Kishnani, Priya S.

“…This report documents the long‐term cognitive and adaptive outcome of children with infantile Pompe disease. Specifically, we describe the cognitive and…”
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Early cognitive development in children with infantile Pompe disease by Spiridigliozzi, Gail A., Heller, James H., Case, Laura E., Jones, Harrison N., Kishnani, Priya S.

“…This report describes the cognitive development of 17 children with infantile Pompe disease who participated in a 52-week clinical trial of enzyme replacement…”
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COGNITIVE OUTCOME OF PATIENTS WITH CLASSIC INFANTILE POMPE DISEASE RECEIVING ENZYME THERAPY by SPIRIDIGLIOZZI, Gail A, HELLER, James H, KISHNANI, Priya S

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The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome by Kishnani, Priya S., Sommer, Barbara R., Handen, Benjamin L., Seltzer, Benjamin, Capone, George T., Spiridigliozzi, Gail A., Heller, James H., Richardson, Sharon, McRae, Thomas

“…The objective of our study was to assess the efficacy and safety of donepezil in young adults with Down syndrome (DS) but no evidence of Alzheimer disease…”
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Safety and efficacy of rivastigmine in adolescents with Down syndrome: long-term follow-up by Heller, James H, Spiridigliozzi, Gail A, Crissman, Blythe G, McKillop, Jane Anne, Yamamoto, Haru, Kishnani, Priya S

“…Following the completion of a 20-week, open-label study of the safety and efficacy of liquid rivastigmine for adolescents with Down syndrome, 5 of the 10…”
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Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study by Heller, James H, Spiridigliozzi, Gail A, Crissman, Blythe G, Sullivan, Jennifer A, Eells, Rebecca L, Li, Jennifer S, Doraiswamy, P Murali, Krishnan, K Ranga, Kishnani, Priya S

“…Individuals with Down syndrome (DS) exhibit a cholinergic deficiency similar to that found in Alzheimer's disease. Cholinesterase inhibitors, used to treat…”
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Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: A clinical report series by Spiridigliozzi, Gail A., Heller, James H., Crissman, Blythe G., Sullivan-Saarela, Jennifer A., Eells, Rebecca, Dawson, Deborah, Li, Jennifer, Kishnani, Priya S.

“…There is growing evidence to support the use of early central cholinergic enhancement to improve cognitive functioning in individuals with Down syndrome (DS)…”
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Clinical trials in children with Down syndrome: Issues from a cognitive research perspective by Heller, James H., Spiridigliozzi, Gail A., Crissman, Blythe G., Sullivan-Saarela, Jennifer A., Li, Jennifer S., Kishnani, Priya S.

“…Clinical and translational research play a key role in the transition of basic research discoveries to effective therapies. In Down syndrome (DS), these…”
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Donepezil effects on language in children with Down syndrome: Results of the first 22-week pilot clinical trial by Heller, James H., Spiridigliozzi, Gail A., Doraiswamy, P. Murali, Sullivan, Jennifer A., Crissman, Bythe G., Kishnani, Priya S.

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Donepezil for the treatment of language deficits in adults with Down syndrome: A preliminary 24-week open trial by Heller, James H., Spiridigliozzi, Gail A., Sullivan, Jennifer A., Doraiswamy, P. Murali, Krishnan, Ranga R., Kishnani, Priya S.

“…At present, there is no proven pharmacologic treatment for cognitive or language impairments in Down syndrome (DS). Cholinergic deficits have been documented…”
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Donepezil for Down's Syndrome by KISHNANI, PRIYA S., SPIRIDIGLIOZZI, GAIL A., HELLER, JAMES H., SULLIVAN, JENNIFER A., DORAISWAMY, P. MURALI, KRISHNAN, K. RANGA RAMA

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Cognitive and Adaptive Functioning of Children With Infantile Pompe Disease Treated With Enzyme Replacement Therapy: Long-Term Follow-Up: Advancements in Pompe Disease by SPIRIDIGLIOZZI, Gail A, HELLER, James H, KISHNANI, Priya S

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The Fluharty Preschool Speech and Language Screening Test: A Population-Based Validation Study Using Sample-Independent Decision Rules by Sturner, Raymond A

“…Two cohorts of children (ages four and five, n=700) were screened with the Fluharty Preschool Speech and Language Screening Test. Results suggest that the…”
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Donepezil use in Down syndrome by Kishnani, Priya S, Sullivan, Jennifer A, Spiridigliozzi, Gail A, Heller, James H, Crissman, Blythe G

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Perception and production of approximant consonants by normal and articulation-delayed preschool children by Broen, P A, Strange, W, Doyle, S S, Heller, J H

“…Disagreement exists concerning the relationship between the perception of phonetic contrasts and their production by both normal and articulation-delayed…”
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Clinical trials in children with down syndrome : Issues from a cognitive research perspective: Current perspectives on Down Syndrome: Selected medical and social issues by HELLER, James H, SPIRIDIGLIOZZI, Gail A, CRISSMAN, Blythe G, SULLIVAN-SAARELA, Jennifer A, LI, Jennifer S, KISHNANI, Priya S

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