Search Results - "Helleberg, Hans"

Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec by Hubálek, František, Cramer, Christian N., Helleberg, Hans, Johansson, Eva, Nishimura, Erica, Schluckebier, Gerd, Steensgaard, Dorte Bjerre, Sturis, Jeppe, Kjeldsen, Thomas B.

“…Insulin icodec is a once-weekly insulin analogue that has a long half-life of approximately 7 days, making it suitable for once weekly dosing. The Insulin…”
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Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase by MALM-ERJEFÄLT, Monika, BJORNSDOTTIR, Inga, VANGGAARD, Jan, HELLEBERG, Hans, LARSEN, Uffe, OOSTERHUIS, Berend, JAAP VAN LIER, Jan, ZDRAVKOVIC, Milan, OLSEN, Anette K

“…Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use for the treatment of type 2 diabetes. To study metabolism and…”
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Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2- b]carbazole by Wei, Yu-Dan, Helleberg, Hans, Rannug, Ulf, Rannug, Agneta

“…Studies to assess the induction of CYP1A1 gene expression by tryptophan derived oxidation products which are suggested as endogenous ligands for the Ah…”
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Structure identification of circulating metabolites from somapacitan, a long-acting growth hormone derivative, and pharmacokinetics after single and multiple subcutaneous dosing in rats by Helleberg, Hans, Lindecrona, Rikke Hvid, Thygesen, Peter, Bjelke, Mads

“…•Somapacitan is a long-acting, albumin-binding, growth hormone derivative.•Eight plasma metabolites were formed after administration of somapacitan in…”
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2032-LB: In Vivo Chain Splitting of Human Insulin by Sturis, Jeppe, Cramer, Christian, Brand, Christian L, Helleberg, Hans, Kurtzhals, Peter, Hubalek, Frantisek

“…Non-insulin receptor-mediated insulin degradation via insulin degrading enzyme has been proposed to play a role in insulin resistance (IR). Recently,…”
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Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species by Jensen, Lene, Helleberg, Hans, Roffel, Ad, van Lier, Jan Jaap, Bjørnsdottir, Inga, Pedersen, Palle Jacob, Rowe, Everton, Derving Karsbøl, Julie, Pedersen, Mette Lund

“…Semaglutide is a human glucagon-like peptide-1 analogue in clinical development for the treatment of type 2 diabetes. The absorption, metabolism and excretion…”
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815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec by HUBALEK, FRANTISEK, CRAMER, CHRISTIAN, HELLEBERG, HANS, JOHANSSON, EVA, SCHLUCKEBIER, GERD, STEENSGAARD, DORTE B., STURIS, JEPPE, KJELDSEN, THOMAS

“…Insulin icodec is a novel basal insulin analogue with a long half-life (196 hours) that is in clinical development for the treatment of diabetes with once…”
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Absorption, metabolism and excretion of once-weekly somapacitan, a long-acting growth hormone derivative, after single subcutaneous dosing in human subjects by Helleberg, Hans, Bjelke, Mads, Damholt, Birgitte Bentz, Pedersen, Palle Jacob, Rasmussen, Michael Højby

“…•Somapacitan is a long-acting, albumin-binding, growth hormone derivative.•Somapacitan was the principal plasma component after dosing.•Five metabolites were…”
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A new group housing approach for non-human primate metabolism studies by Stow, Ruth, Kendrick, John, Ibbotson, Neil, Adjin-tettey, Georgina, Murphy, Beverley, Trojca, Richard, Miller, James, Konradsen, Gitte, Øvlisen, Kirstine, Helleberg, Hans, Hansen, Jesper Juhl

“…Understanding the absorption, distribution, metabolism and excretion (ADME) of candidate drugs in preclinical species is an integral part of the safety and…”
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Comparison of the Tissue Distribution of a Long-Circulating Glucagon-like Peptide‑1 Agonist Determined by Positron Emission Tomography and Quantitative Whole-Body Autoradiography by Fernandes, Eduardo Felipe Alves, Wilbs, Jonas, Raavé, Rene, Jacobsen, Christian Borch, Toftelund, Hanne, Helleberg, Hans, Boswinkel, Milou, Heskamp, Sandra, Gustafsson, Magnus Bernt Frederik, Bjørnsdottir, Inga

“…Positron emission tomography (PET) is a molecular imaging modality that enables non-invasive visualization of tracer distribution and pharmacology. Recently,…”
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A new approach for measuring protein adducts from benzo[a]pyrene diolepoxide by high performance liquid chromatography/tandem mass spectrometry by Helleberg, Hans, Törnqvist, Margareta

“…The long‐range goal of the present study is the development of a general approach for in vivo dosimetry of reactive metabolites of polycyclic aromatic…”
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Studies of dose distribution, premutagenic events and mutation frequencies for benzo[a]pyrene aiming at low dose cancer risk estimation by Helleberg, Hans, Xu, Honglan, Ehrenberg, Lars, Hemminki, Kari, Rannug, Ulf, Törnqvist, Margareta

“…Cancer risk assessment of polycyclic aromatic hydrocarbons (PAH) is complicated by several of these compounds exerting a promoter action leading to high tumour…”
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