Search Results - "Hellberg, M R"

Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist by Hellberg, M R, Sallee, V L, McLaughlin, M A, Sharif, N A, Desantis, L, Dean, T R, Zinke, P W

“…Travoprost is the isopropyl ester prodrug of a high affinity, selective FP prostaglandin full receptor agonist. In contrast to travoprost acid's high affinity…”
Get more information

Novel Esters and Amides of Nonsteroidal Antiinflammatory Carboxylic Acids as Antioxidants and Antiproliferative Agents by Hellberg, Mark R, Namil, Abdelmoula, Delgado, Pete, David, Karen C, Kessler, Timothy L, Graff, Gustav, Haggard, Karen S, Nixon, Jon C

“…A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal antiinflammatory drug naproxen was designed to have both antiinflammatory and…”
Get full text

Suppression of Post-Vitrectomy Lens Changes in the Rabbit by Novel Benzopyranyl Esters and Amides by Kuszak, J.R., Sivak, J.G., Moran, K.L., Scheib, S.A., Garner, W.H., Ke, T.L., Hellberg, M.R., Graff, G.

“…This study reports for the first time a therapeutic modality for the suppression of posterior subcapsular cataract (PSC) formation in an animal model (rabbit)…”
Get full text

Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides by David, Karen C, Brady, Milton T, Weimer, Lori K, Hellberg, Mark R, Nixon, Jon C, Graff, Gustav

“…Selected ester- (AL-5898 and AL-8417) and amide-linked benzopyran analogues (AL-7538 and AL-12615) were evaluated in vitro for their ability to inhibit key…”
Get full text

Evaluation of Inducible Nitric Oxide Synthase in Glaucomatous Optic Neuropathy and Pressure-Induced Optic Nerve Damage by Pang, Iok-Hou, Johnson, Elaine C, Jia, Lijun, Cepurna, William O, Shepard, Allan R, Hellberg, Mark R, Clark, Abbot F, Morrison, John C

“…To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy. Chronic elevation of rat intraocular pressure (IOP)…”
Get full text

beta -Oxygenated Analogues of the 5-HT sub(2A) Serotonin Receptor Agonist 1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane by Glennon, R A, Bondarev, M L, Khorana, N, Young, R, May, JA, Hellberg, M R, McLaughlin, MA, Sharif, NA

“…Activation of 5-HT sub(2A) serotonin receptors represents a novel approach to lowering intraocular pressure. Because 5-HT sub(2A) serotonin receptor agonists…”
Get full text

Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys by May, Jesse A, McLaughlin, Marsha A, Sharif, Najam A, Hellberg, Mark R, Dean, Thomas R

“…Published investigations of serotonin-1A (5-hydroxytryptamine1A; 5-HT1A) receptor agonists and serotonin-2A (5-hydroxytryptamine2A; 5-HT2A) receptor…”
Get more information

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey by Selliah, Robert D, Hellberg, Mark R, Sharif, Najam A, McLaughlin, Marsha A, Williams, Gary W, Scott, Daniel A, Earnest, David, Haggard, Karen S, Dennis Dean, W, Delgado, Pete, Gaines, Michael S, Conrow, Raymond E, Klimko, Peter G

“…Graphic A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains…”
Get full text

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents by Hellberg, Mark R., Conrow, Raymond E., Sharif, Najam A., McLaughlin, Marsha A., Bishop, John E., Crider, Julie Y., Dean, W.Dennis, DeWolf, Kevin A., Pierce, David R., Sallee, Verney L., Selliah, Robert D., Severns, Bryon S., Sproull, Steven J., Williams, Gary W., Zinke, Paul W., Klimko, Peter G.

“…A series of prostaglandin DP agonists containing a 3-oxa-15-cyclohexyl motif was synthesized and evaluated in several in vitro and in vivo biological assays…”
Get full text

Preparation of optically active, functionalized cis-△6-1-octalones by BOGER, D. L, MULLICAN, M. D, HELLBERG, M. R, PATEL, M

Get full text

Local Fibrinolysis in Acute Thromboembolism of the Superior Mesenteric Artery by S. Mellander, R. Hellberg, P.-Å. Karlqvist, M. Svahn

Get full text