Search Results - "Hella, Jerry"
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Diagnostic accuracy of computer-aided detection of pulmonary tuberculosis in chest radiographs: a validation study from sub-Saharan Africa
Published in PloS one (05-09-2014)“…Chest radiography to diagnose and screen for pulmonary tuberculosis has limitations, especially due to inter-reader variability. Automating the interpretation…”
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2
Anemia in tuberculosis cases and household controls from Tanzania: Contribution of disease, coinfections, and the role of hepcidin
Published in PloS one (20-04-2018)“…Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which…”
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3
Prevalence of chronic obstructive pulmonary disease and associated factors among small-holder fish vendors along coastal areas in Tanzania
Published in BMC pulmonary medicine (02-08-2023)“…In Tanzania little is known about how the respiratory system of small-holder fish vendors is affected by occupational exposure to biomass smoke and other…”
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4
Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania
Published in Scientific reports (23-04-2024)“…The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of…”
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5
High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania
Published in PloS one (29-04-2021)“…To determine the prevalence of tuberculosis (TB) disease and infection as well as incident TB disease among people who use drugs (PWUD) attending Medication…”
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6
Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Published in PLoS computational biology (01-01-2022)“…Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays…”
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7
Case–control diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood
Published in Scientific reports (23-06-2021)“…CD4 T cell phenotyping-based blood assays have the potential to meet WHO target product profiles (TPP) of non-sputum-biomarker-based tests to diagnose…”
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HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa
Published in PLoS pathogens (01-05-2024)“…Persons living with HIV are known to be at increased risk of developing tuberculosis (TB) disease upon infection with Mycobacterium tuberculosis (Mtb)…”
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Tuberculosis transmission in public locations in Tanzania: A novel approach to studying airborne disease transmission
Published in The Journal of infection (01-09-2017)“…For tuberculosis (TB) transmission to occur, an uninfected individual must inhale the previously infected breath. Our objective was to identify potential TB…”
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10
Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV demonstrates lot-to-lot variability
Published in PloS one (31-05-2024)“…There is an urgent need for rapid, non-sputum point-of-care diagnostics to detect tuberculosis. This prospective trial in seven high tuberculosis burden…”
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11
Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania
Published in PLoS neglected tropical diseases (08-02-2017)“…Helminth infections can negatively affect the immunologic host control, which may increase the risk of progression from latent Mycobacterium tuberculosis…”
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Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania
Published in PLoS pathogens (01-04-2023)“…In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However,…”
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13
Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: The prospective Kilombero and Ulanga antiretroviral cohort
Published in PloS one (04-03-2020)“…In sub-Saharan Africa, diagnosis and management of extrapulmonary tuberculosis (EPTB) in people living with HIV (PLHIV) remains a major challenge. This study…”
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Explaining patient delay in healthcare seeking and loss to diagnostic follow-up among patients with presumptive tuberculosis in Tanzania: a mixed-methods study
Published in BMC health services research (05-04-2019)“…Delay in healthcare seeking and loss to diagnostic follow-up (LDFU) contribute to substantial increase in tuberculosis (TB) morbidity and mortality. We…”
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Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania
Published in PloS one (12-04-2019)“…Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1-7. Recent advances in rapid…”
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Diagnostic accuracy of a sequence-specific Mtb -DNA hybridization assay in urine: a case-control study including subclinical TB cases
Published in Microbiology spectrum (04-06-2024)“…Tuberculosis (TB) caused by ( ) remains one of the deadliest infectious diseases globally. Timely diagnosis is a key step in the management of TB patients and…”
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Airborne transmission risks of tuberculosis and COVID-19 in schools in South Africa, Switzerland, and Tanzania: Modeling of environmental data
Published in PLOS global public health (2024)“…The COVID-19 pandemic renewed interest in airborne transmission of respiratory infections, particularly in congregate indoor settings, such as schools. We…”
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The Sputum Microbiome in Pulmonary Tuberculosis and Its Association With Disease Manifestations: A Cross-Sectional Study
Published in Frontiers in microbiology (20-08-2021)“…Each day, approximately 27,000 people become ill with tuberculosis (TB), and 4,000 die from this disease. Pulmonary TB is the main clinical form of TB, and…”
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Detection of Mycobacterium tuberculosis by EasyNAT diagnostic kit in sputum samples from Tanzania
Published in Journal of clinical microbiology (01-04-2015)“…The EasyNAT assay was evaluated for the detection of tuberculosis in sputum smears from presumptive pulmonary tuberculosis (TB) patients in an African high-TB…”
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Do Instructional Videos on Sputum Submission Result in Increased Tuberculosis Case Detection? A Randomized Controlled Trial
Published in PloS one (29-09-2015)“…We examined the effect of an instructional video about the production of diagnostic sputum on case detection of tuberculosis (TB), and evaluated the acceptance…”
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