Search Results - "Hella, Hanne"

Addiction to c-MYC in multiple myeloma by Holien, Toril, Våtsveen, Thea Kristin, Hella, Hanne, Waage, Anders, Sundan, Anders

“…In multiple myeloma, c-MYC is activated and contributes to the malignant phenotype. Targeting MYC by short hairpin RNA induced cell death in myeloma cell…”
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BMPR2 inhibits activin and BMP signaling via wild-type ALK2 by Olsen, Oddrun Elise, Sankar, Meenu, Elsaadi, Samah, Hella, Hanne, Buene, Glenn, Darvekar, Sagar Ramesh, Misund, Kristine, Katagiri, Takenobu, Knaus, Petra, Holien, Toril

“…TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand-dependent downstream signaling. Activin A, a TGF-β superfamily…”
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Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable VkMYC model of multiple myeloma by Nedal, Tonje Marie Vikene, Moen, Siv Helen, Roseth, Ingrid Aass, Tryggestad, Synne Stokke, Aass, Kristin Roseth, Hov, Gunhild Garmo, Hella, Hanne, Sponaas, Anne-Marit, Standal, Therese

“…Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely…”
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Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors by Olsen, Oddrun Elise, Hella, Hanne, Elsaadi, Samah, Jacobi, Carsten, Martinez-Hackert, Erik, Holien, Toril

“…Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the…”
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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B by Olsen, Oddrun Elise, Wader, Karin Fahl, Hella, Hanne, Mylin, Anne Kærsgaard, Turesson, Ingemar, Nesthus, Ingerid, Waage, Anders, Sundan, Anders, Holien, Toril

“…Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum…”
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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells by Andersson-Rusch, Clara, Liu, Bin, Quist-Løkken, Ingrid, Upton, Paul D., Olsen, Oddrun Elise, Hella, Hanne, Yang, Xudong, Tong, Zhen, Morrell, Nicholas W., Holien, Toril, Li, Wei

“…Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many…”
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Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen by Tryggestad, Synne Stokke, Roseth, Ingrid Aass, Aass, Kristin Roseth, Ørning, Nadia Elise Helene, Mjelle, Robin, Hella, Hanne, Standal, Therese

“…Infections are common in plasma cell cancer multiple myeloma (MM) due to disease-related immune deficiencies and cancer treatment. Myeloma cells express…”
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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells by Quist-Løkken, Ingrid, Andersson-Rusch, Clara, Kastnes, Martin Haugrud, Kolos, Jürgen Markus, Jatzlau, Jerome, Hella, Hanne, Olsen, Oddrun Elise, Sundan, Anders, Knaus, Petra, Hausch, Felix, Holien, Toril

“…The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state…”
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Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate by Holien, Toril, Olsen, Oddrun E., Misund, Kristine, Hella, Hanne, Waage, Anders, Rø, Torstein B., Sundan, Anders

“…Objectives The use of new drugs has improved the treatment of multiple myeloma and diffuse large B‐cell lymphoma (DLBCL). Nevertheless, over time many patients…”
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Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone by Westhrin, Marita, Holien, Toril, Zahoor, Muhammad, Moen, Siv Helen, Buene, Glenn, Størdal, Berit, Hella, Hanne, Yuan, Huipin, Bruijn, Joost D, Martens, Anton, Groen, Richard WJ, Bosch, Fatima, Smith, Ulf, Sponaas, Anne‐Marit, Sundan, Anders, Standal, Therese

“…ABSTRACT Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease,…”
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CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and in vitro osteoblastogenesis by Nørgaard, Nikolai N, Holien, Toril, Jönsson, Sofia, Hella, Hanne, Espevik, Terje, Sundan, Anders, Standal, Therese

“…The TLR9 agonist CpG-oligodeoxynucleotide (CpG-ODN) with a phosphorothioate backbone (PTO-CpG-ODN) is evaluated in clinical trials as a vaccine adjuvant or as…”
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P-202 SLAMF1-derived peptide P7N4-Pen as anti-myeloma treatment by Mestvedt, Ingvild, Standal, Therese, Yurchenko, Maria, Espevik, Terje, Misund, Kristine, Hella, Hanne, Slørdahl, Tobias

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TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan by Håland, Erling, Moen, Ingrid Nyhus, Veidal, Elias, Hella, Hanne, Misund, Kristine, Slørdahl, Tobias S., Starheim, Kristian K.

“…Multiple myeloma (MM) is an incurable cancer caused by malignant transformation of plasma cells. Transforming growth factor-β activated kinase 1 (MAP3K7, TAK1)…”
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BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone by Holien, Toril, Westhrin, Marita, Moen, Siv Helen, Zahoor, Muhammad, Buene, Glenn, Størdal, Berit, Hella, Hanne, Yuan, Huipin, de Bruijn, Joost D, Martens, Anton, Groen, Richard WJ, Bosch, Fatima, Smith, Ulf, Sundan, Anders, Standal, Therese

“…TH and MW contributed equally to this work. Background Multiple myeloma is caused by an accumulation of malignant plasma cells in the bone marrow. Myeloma is…”
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Activins as Dual Specificity TGF-[beta] Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors by Olsen, Oddrun Elise, Hella, Hanne, Elsaadi, Samah, Jacobi, Carsten, Martinez- Hackert, Erik, Holien, Toril

“…Activins belong to the transforming growth factor (TGF)-[beta] family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to…”
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Abstract 3130: Dependency on c-MYC in multiple myeloma by Holien, Toril, Våtsveen, Thea K., Hella, Hanne, Waage, Anders, Sundan, Anders

“…Abstract The oncogene c-MYC is deregulated in multiple myeloma. Importantly, the activity of c-MYC is elevated in plasma cells in patients with myeloma…”
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Caspase‐8 regulates the expression of pro‐ and anti‐inflammatory cytokines in human bone marrow‐derived mesenchymal stromal cells by Moen, Siv H., Westhrin, Marita, Zahoor, Muhammad, Nørgaard, Nikolai N., Hella, Hanne, Størdal, Berit, Sundan, Anders, Nilsen, Nadra J., Sponaas, Anne‐Marit, Standal, Therese

“…Introduction Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their…”
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High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis by Brenne, Anne-Tove, Fagerli, Unn-Merete, Shaughnessy Jr, John D., Våtsveen, Thea Kristin, Rø, Torstein Baade, Hella, Hanne, Zhan, Fenghuang, Barlogie, Bart, Sundan, Anders, Børset, Magne, Waage, Anders

“…Background:  BCL3 is a putative oncogene encoding for a protein belonging to the inhibitory κB‐family. We experienced that this putative oncogene was a common…”
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Nonlabeled secondary antibodies augment/maintain the binding of primary, specific antibodies to cell membrane antigens by Lamvik, Jon, Hella, Hanne, Liabakk, Nina‐Beate, Halaas, Øyvind

“…Background In studies on surface membrane antigen expression using immunofluorescence techniques, it is commonly observed that direct staining gives weaker…”
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