Search Results - "Hell, Johannes W"

CaMKII: claiming center stage in postsynaptic function and organization by Hell, Johannes W

“…While CaMKII has long been known to be essential for synaptic plasticity and learning, recent work points to new dimensions of CaMKII function in the nervous…”
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How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD by Hell, Johannes W

“…Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now…”
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Distinct Eligibility Traces for LTP and LTD in Cortical Synapses by He, Kaiwen, Huertas, Marco, Hong, Su Z., Tie, XiaoXiu, Hell, Johannes W., Shouval, Harel, Kirkwood, Alfredo

“…In reward-based learning, synaptic modifications depend on a brief stimulus and a temporally delayed reward, which poses the question of how synaptic activity…”
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Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels by Dai, Shuiping, Hall, Duane D, Hell, Johannes W

“…Department of Pharmacology, University of Iowa, Iowa City, Iowa This review addresses the localized regulation of voltage-gated ion channels by…”
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory by Yasuda, Ryohei, Hayashi, Yasunori, Hell, Johannes W.

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Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome by Hamilton, Andrew M., Oh, Won Chan, Vega-Ramirez, Hugo, Stein, Ivar S., Hell, Johannes W., Patrick, Gentry N., Zito, Karen

“…Growth of new dendritic spines contributes to experience-dependent circuit plasticity in the cerebral cortex. Yet the signaling mechanisms leading to new spine…”
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Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity by Matt, Lucas, Kim, Karam, Chowdhury, Dhrubajyoti, Hell, Johannes W

“…Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking,…”
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The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength by Barcomb, Kelsey, Hell, Johannes W., Benke, Tim A., Bayer, K. Ulrich

“…Learning, memory, and cognition are thought to require normal long-term potentiation (LTP) of synaptic strength, which in turn requires binding of the…”
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The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions by Shams, Shahin, Martinez, Joseph M, Dawson, John R D, Flores, Juan, Gabriel, Marina, Garcia, Gustavo, Guevara, Amanda, Murray, Kaitlin, Pacifici, Noah, Vargas, Maxemiliano V, Voelker, Taylor, Hell, Johannes W, Ashouri, Judith F

“…Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted…”
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Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains by Zhang, Lei, Zhang, Peng, Wang, Guangfu, Zhang, Huaye, Zhang, Yajun, Yu, Yilin, Zhang, Mingxu, Xiao, Jian, Crespo, Piero, Hell, Johannes W., Lin, Li, Huganir, Richard L., Zhu, J. Julius

“…How signaling molecules achieve signal diversity and specificity is a long-standing cell biology question. Here we report the development of a targeted…”
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DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific by Goodell, Dayton J., Zaegel, Vincent, Coultrap, Steven J., Hell, Johannes W., Bayer, K. Ulrich

“…The death-associated protein kinase 1 (DAPK1) is a potent mediator of neuronal cell death. Here, we find that DAPK1 also functions in synaptic plasticity by…”
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Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis by Schampel, Andrea, Volovitch, Oleg, Koeniger, Tobias, Scholz, Claus-Jürgen, Jörg, Stefanie, Linker, Ralf A., Wischmeyer, Erhard, Wunsch, Marie, Hell, Johannes W., Ergün, Süleyman, Kuerten, Stefanie

“…Despite continuous interest in multiple sclerosis (MS) research, there is still a lack of neuroprotective strategies, because the main focus has remained on…”
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Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces by Hong, Su Z., Mesik, Lukas, Grossman, Cooper D., Cohen, Jeremiah Y., Lee, Boram, Severin, Daniel, Lee, Hey-Kyoung, Hell, Johannes W., Kirkwood, Alfredo

“…Reinforcement allows organisms to learn which stimuli predict subsequent biological relevance. Hebbian mechanisms of synaptic plasticity are insufficient to…”
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Homeostatic synaptic scaling: molecular regulators of synaptic AMPA-type glutamate receptors by Chowdhury, Dhrubajyoti, Hell, Johannes W

“…The ability of neurons and circuits to maintain their excitability and activity levels within the appropriate dynamic range by homeostatic mechanisms is…”
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Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice by Patriarchi, Tommaso, Amabile, Sonia, Frullanti, Elisa, Landucci, Elisa, Lo Rizzo, Caterina, Ariani, Francesca, Costa, Mario, Olimpico, Francesco, W Hell, Johannes, M Vaccarino, Flora, Renieri, Alessandra, Meloni, Ilaria

“…Rett syndrome (RTT) is a severe neurodevelopmental disorder associated with mutations in either MECP2, CDKL5 or FOXG1. The precise molecular mechanisms that…”
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Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex by Rajani, Vishaal, Maziar, Aida, Man, Kwun Nok Mimi, Hell, Johannes W, Yuan, Qi

“…In the hippocampus, the contributions of N-methyl-D-aspartate receptors (NMDARs) and L-type calcium channels (LTCCs) to neuronal transmission and synaptic…”
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Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation by Martín-Aragón Baudel, Miguel, Flores-Tamez, Victor A., Hong, Junyoung, Reddy, Gopyreddy R., Maillard, Pauline, Burns, Abby E., Man, Kwun Nok Mimi, Sasse, Kent C., Ward, Sean M., Catterall, William A., Bers, Donald M., Hell, Johannes W., Nieves-Cintrón, Madeline, Navedo, Manuel F.

“…BACKGROUNDL-type CaV1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that…”
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Acute phosphatidylinositol 4,5 bisphosphate depletion destabilizes sarcolemmal expression of cardiac L-type Ca2+ channel CaV1.2 by Voelker, Taylor L, del Villar, Silvia G, Westhoff, Maartje, Costa, Alexandre D, Coleman, Andrea M, Hell, Johannes W, Horne, Mary C, Dickson, Eamonn J, Dixon, Rose E

“…CaV1.2 channels are critical players in cardiac excitation–contraction coupling, yet we do not understand how they are affected by an important therapeutic…”
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory by Yasuda, Ryohei, Hayashi, Yasunori, Hell, Johannes W.

“…Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity,…”
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β2 Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models by Wang, Dayong, Fu, Qin, Zhou, Yuan, Xu, Bing, Shi, Qian, Igwe, Benedict, Matt, Lucas, Hell, Johannes W., Wisely, Elena V., Oddo, Salvatore, Xiang, Yang K.

“…Alzheimer disease (AD) is characterized by neurodegeneration marked by loss of synapses and spines associated with hyperphosphorylation of tau protein…”
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