Search Results - "Hell, André"

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib by Han, Chong, Savage, Scott, Al-Sayah, Mohammad, Yajima, Herbert, Remarchuk, Travis, Reents, Reinhard, Wirz, Beat, Iding, Hans, Bachmann, Stephan, Fantasia, Serena M, Scalone, Michelangelo, Hell, André, Hidber, Pirmin, Gosselin, Francis

“…A highly efficient asymmetric synthesis of the Akt kinase inhibitor ipatasertib (1) is reported. The bicyclic pyrimidine 2 starting material was prepared via a…”
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Development of a Practical and Greener Process for the Dual Leucine Zipper Kinase Inhibitor GDC-0134 Comprising Two SNAr Reactions, Oxidation and Suzuki Coupling by Hoffmann-Emery, Fabienne, Niedermann, Katrin, Rege, Pankaj D, Konrath, Manuel, Lautz, Christian, Kraft, Anne Katrin, Steiner, Carine, Bliss, Fritz, Hell, André, Fischer, Rolf, Carrera, Diane E, Beaudry, Danial, Angelaud, Remy, Malhotra, Sushant, Gosselin, Francis

“…A sustainable second-generation process for GDC-0134 was developed with a particular focus on safety and greenness, while complying with strong specifications…”
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Development of a Practical and Greener Process for the Dual Leucine Zipper Kinase Inhibitor GDC-0134 Comprising Two S N Ar Reactions, Oxidation and Suzuki Coupling by Hoffmann-Emery, Fabienne, Niedermann, Katrin, Rege, Pankaj D., Konrath, Manuel, Lautz, Christian, Kraft, Anne Katrin, Steiner, Carine, Bliss, Fritz, Hell, André, Fischer, Rolf, Carrera, Diane E., Beaudry, Danial, Angelaud, Remy, Malhotra, Sushant, Gosselin, Francis

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