Search Results - "Helinski, Jadwiga D."

Doxorubicin-conjugated quantum dots to target alveolar macrophages and inflammation by Chakravarthy, Krishnan V., PhD, Davidson, Bruce A., PhD, Helinski, Jadwiga D., MS, Ding, Hong, PhD, Law, Wing-Cheung, BS, Yong, Ken-Tye, PhD, Prasad, Paras N., PhD, Knight, Paul R., MD, PhD

“…Abstract The ability to provide targeted therapeutic delivery in the lung would be a major advancement in pharmacological treatments for many pulmonary…”
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Role of macrophage chemoattractant protein-1 in acute inflammation after lung contusion by Suresh, Madathilparambil V, Yu, Bi, Machado-Aranda, David, Bender, Matthew D, Ochoa-Frongia, Laura, Helinski, Jadwiga D, Davidson, Bruce A, Knight, Paul R, Hogaboam, Cory M, Moore, Bethany B, Raghavendran, Krishnan

“…Lung contusion (LC), commonly observed in patients with thoracic trauma is a leading risk factor for development of acute lung injury/acute respiratory…”
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Dietary advanced glycation end-products, its pulmonary receptor, and high mobility group box 1 in aspiration lung injury by Smit, Peter J., MD, MS, Guo, Weidun A., MD, PhD, Davidson, Bruce A., PhD, Mullan, Barbara A., MS, Helinski, Jadwiga D., MS, Knight, Paul R., MD, PhD

“…Abstract Background Gastric aspiration is a significant cause of acute lung injury and acute respiratory distress syndrome. Environmental risk factors, such as…”
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Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages by Davidson, Bruce A., Alluri, Ravi, Helinski, Jadwiga D., Fung, Christopher, Fernandez, F., Knight, Paul R.

“…Gastric aspiration increases the risks for developing secondary bacterial pneumonia. Cytokine elaboration through pathogen recognition receptors (PRRs) is an…”
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Superimposed Gastric Aspiration Increases the Severity of Inflammation and Permeability Injury in a Rat Model of Lung Contusion by Raghavendran, Krishnan, M.D, Davidson, Bruce A., B.S, Huebschmann, John C., M.D, Helinski, Jadwiga D., M.S, Hutson, Alan D., Ph.D, Dayton, Merril T., M.D, Notter, Robert H., M.D., Ph.D, Knight, Paul R., M.D., Ph.D

“…Introduction Lung contusion (LC) from blunt thoracic trauma is a clinically-prevalent condition that can progress to acute lung injury (ALI) and acute…”
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PROGRESSIVE, SEVERE LUNG INJURY SECONDARY TO THE INTERACTION OF INSULTS IN GASTRIC ASPIRATION by KNIGHT, Paul R, DAVIDSON, Bruce A, NADER, Nader D, HELINSKI, Jadwiga D, MARSCHKE, Cristi J, RUSSO, Thomas A, HUTSON, Alan D, NOTTER, Robert H, HOLM, Bruce A

“…This study examines lung injury and inflammation over 24 hours following intratracheal instillation of hydrochloric acid (acid), small nonacidic gastric…”
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Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance by Rotta, Alexandre T, Shiley, Kevin T, Davidson, Bruce A, Helinski, Jadwiga D, Russo, Thomas A, Knight, Paul R

“…OBJECTIVETo establish a model of secondary bacterial pneumonia following gastric aspiration and to identify possible mechanisms involved in the suppressed…”
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Lung contusion: inflammatory mechanisms and interaction with other injuries by Raghavendran, Krishnan, Notter, Robert H, Davidson, Bruce A, Helinski, Jadwiga D, Kunkel, Steven L, Knight, Paul R

“…This article reviews current animal models and laboratory studies investigating the pathophysiology of lung contusion (LC), a common and severe condition in…”
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Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia by Russo, Thomas A, Bartholomew, Lori A, Davidson, Bruce A, Helinski, Jadwiga D, Carlino, Ulrike B, Knight, 3rd, Paul R, Beers, Michael F, Atochina, Elena N, Notter, Robert H, Holm, Bruce A

“…An in vivo rat model was used to evaluate the effects of Escherichia coli pneumonia on lung function and surfactant in bronchoalveolar lavage (BAL). Total…”
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A Rat Model for Isolated Bilateral Lung Contusion from Blunt Chest Trauma by Raghavendran, Krishnan, Davidson, Bruce A., Helinski, Jadwiga D., Marschke, Cristi J., Manderscheid, Patricia, Woytash, James A., Notter, Robert H., Knight, Paul R.

“…Lung contusion affects 17%–25% of adult blunt trauma patients, and is the leading cause of death from blunt thoracic injury. A small animal model for isolated…”
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Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion by Lakshminrusimha, Satyan, Suresh, Madathilparambil V, Knight, Paul R, Gugino, Sylvia F, Davidson, Bruce A, Helinski, Jadwiga D, Nielsen, Lori C, Russell, James A, Yu, Bi, Zeng, Lixia, Pennathur, Subramaniam, Raghavendran, Krishnan

“…The mechanisms contributing to hypoxia in lung contusion (LC) remain unclear and not temporally associated with the peak onset of acute inflammation. We…”
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The evolution of isolated bilateral lung contusion from blunt chest trauma in rats : Cellular and cytokine responses by RAGHAVENDRAN, Krishnan, DAVIDSON, Bruce A, WOYTASH, James A, HELINSKI, Jadwiga D, MARSCHKE, Cristi J, MANDERSCHEID, Patricia A, NOTTER, Robert H, KNIGH, Paul R

“…Lung contusion is the leading cause of death from blunt thoracic trauma in adults, but its mechanistic pathophysiology remains unclear. This study uses a…”
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The role of tumor necrosis factor-α in the pathogenesis of aspiration pneumonitis in rats by DAVIDSON, B. A, KNIGHT, P. R, HELINSKI, J. D, NADER, N. D, SHANLEY, T. P, JOHNSON, K. J

“…Aspiration pneumonitis is characterized by proteinaceous pulmonary edema and acute infiltration of neutrophils into the alveolar space. This study examined the…”
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81. Biomarkers of Lung Contusion With/Without Superimposed Gastric Aspiration in Rats by Guo, W. Alan, Davidson, Bruce A, Hutson, Alan D, Helinski, Jadwiga D, Dayton, Merril T, Knight, Paul R, Raghavendran, Krishnan

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The effects of Escherichia coli capsule, O-antigen, host neutrophils, and complement in a rat model of Gram-negative pneumonia by Russo, Thomas A, Davidson, Bruce A, Carlino-MacDonald, Ulrike B, Helinski, Jadwiga D, Priore, Roger L, Knight, Paul R

“…Gram-negative enteric bacilli are agents of life-threatening pneumonia. The role of the bacterial capsule and O-antigen moiety of lipopolysaccharide in the…”
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Dietary AGE-Associated RAGE and HMGB1 in Aspiration Lung Injury by Smit, Peter J., Guo, Weidun A., Davidson, Bruce A., Mullan, Barbara A., Helinski, Jadwiga D., Knight, Paul R.

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Predictive Modeling and Inflammatory Biomarkers in Rats With Lung Contusion and Gastric Aspiration by Raghavendran, Krishnan, Davidson, Bruce A., Hutson, Alan D., Helinski, Jadwiga D., Nodzo, Scott R., Notter, Robert H., Knight, Paul R.

“…BACKGROUND:This study uses statistical predictive modeling and hierarchical cluster analyses to examine inflammatory mediators and cells in bronchoalveolar…”
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Effect of dietary fat on glomerular lipid composition and angiotensin II receptors by Awad, A B, Brown, G P, Fink, C S, Helinski, J D

“…Nutritional factors are major etiologic determinants which may affect the incidence or severity of hypertension. Since angiotensin II (Ang II) has a role in…”
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Abstract 88: Alterations in Pulmonary Vasoreactivity Following Lung Contusion in Rats by Lakshminrusimha, Satyan, Davidson, Bruce A, Ryan, Rita M, Helinski, Jadwiga D, Raghavendran, Krishnan

“…Abstract only…”
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GASTRIC ASPIRATION TRANSIENTLY IMPAIRS PULMONARY BACTERIAL CLEARANCE: 462 by Rotta, Alexandre T, Tauber, Alla, Helinski, Jadwiga D, Davidson, Bruce A, Russo, Thomas A, Knight, Paul R

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