Search Results - "Helgeson, Roger C."

Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold by Basler, Sophie, Studer, Sabine, Zou, Yike, Mori, Takahiro, Ota, Yusuke, Camus, Anna, Bunzel, H. Adrian, Helgeson, Roger C., Houk, K. N., Jiménez-Osés, Gonzalo, Hilvert, Donald

“…New enzyme catalysts are usually engineered by repurposing the active sites of natural proteins. Here we show that design and directed evolution can be used to…”
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Reversible Photochemically Gated Transformation of a Hemicarcerand to a Carcerand by Wang, Hao, Liu, Fang, Helgeson, Roger C., Houk, Kendall N.

“…Guests in a gated community: Introduction of two anthracene groups into a linker in a hemicarcerand creates a new type of photochemically controlled gated…”
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Building on Cram’s Legacy: Stimulated Gating in Hemicarcerands by Liu, Fang, Helgeson, Roger C, Houk, K. N

“…Donald Cram’s pioneering Nobel Prize-winning work on host–guest molecules led eventually to his creation of the field of container molecules. Cram defined two…”
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Controlled Gating of a Hemicarcerand by Disulfide−Dithiol Interchange by Helgeson, Roger C, Hayden, Amy E, Houk, K. N

“…Introduction of a disulfide unit into the linker of a hemicarcerand creates a new way to control the entry and exit of guests. When the disulfide bond is…”
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Origins of the Endo and Exo Selectivities in Cyclopropenone, Iminocyclopropene, and Triafulvene Diels–Alder Cycloadditions by Levandowski, Brian J, Hamlin, Trevor A, Helgeson, Roger C, Bickelhaupt, F. Matthias, Houk, K. N

“…The endo and exo stereoselectivities of Diels–Alder reactions of cyclopropenone, iminocyclopropene, and substituted triafulvenes with butadiene were…”
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Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis by Richter, Florian, Blomberg, Rebecca, Khare, Sagar D, Kiss, Gert, Kuzin, Alexandre P, Smith, Adam J. T, Gallaher, Jasmine, Pianowski, Zbigniew, Helgeson, Roger C, Grjasnow, Alexej, Xiao, Rong, Seetharaman, Jayaraman, Su, Min, Vorobiev, Sergey, Lew, Scott, Forouhar, Farhad, Kornhaber, Gregory J, Hunt, John F, Montelione, Gaetano T, Tong, Liang, Houk, K. N, Hilvert, Donald, Baker, David

“…Nucleophilic catalysis is a general strategy for accelerating ester and amide hydrolysis. In natural active sites, nucleophilic elements such as catalytic…”
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Host-guest complexation. 48. Octol building blocks for cavitands and carcerands by Tunstad, Linda M, Tucker, John A, Dalcanale, Enrico, Weiser, Jurgen, Bryant, Judi A, Sherman, John C, Helgeson, Roger C, Knobler, Carolyn B, Cram, Donald J

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Reversible Photochemically Gated Transformation of a Hemicarcerand to a Carcerand by Wang, Hao, Liu, Fang, Helgeson, Roger C., Houk, Kendall N.

“…Wach‐ und Schließgesellschaft: Die Einführung von zwei Anthracen‐Einheiten in eine Brücke erzeugt einen neuartigen Hemicarceranden. Das reversible Öffnen und…”
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Host-guest complexation. 50. Potassium and sodium ion-selective chromogenic ionophores by Helgeson, Roger C, Czech, Bronislaw P, Chapoteau, Eddy, Gebauer, Carl R, Kumar, Anand, Cram, Donald J

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Host-guest complexation. 45. A highly preorganized chromogenic spherand indicator system specific for sodium and lithium ions by Cram, Donald J, Carmack, Richard A, Helgeson, Roger C

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Host-guest complexation. 20. Chiral recognition in transport as a molecular basis for a catalytic resolving machine by Newcomb, Martin, Toner, John L, Helgeson, Roger C, Cram, Donald J

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Reversible Photochemically Gated Transformation of a Hemicarcerand to a Carcerand by Wang, Hao, Liu, Fang, Helgeson, Roger C., Houk, Kendall N.

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Spherands - ligands whose binding of cations relieves enforced electron-electron repulsions by Cram, Donald J, Kaneda, Takahiro, Helgeson, Roger C, Lein, George M

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Host-guest complexation. 8. Macrocyclic polyethers shaped by two rigid substituted dinaphthyl or ditetralyl units by Cram, Donald J, Helgeson, Roger C, Peacock, Stephen C, Kaplan, Lester J, Domeier, Linda A, Moreau, Patrice, Koga, Kenji, Mayer, James M, Chao, Y

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Host-guest complexation. 46. Cavitands as open molecular vessels form solvates by Cram, Donald J, Karbach, Stefan, Kim, Hye Eun, Knobler, Carolyn B, Maverick, Emily F, Ericson, John L, Helgeson, Roger C

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Host-guest complexation. 18. Effects on cation binding of convergent ligand sites appended to macrocyclic polyethers by Helgeson, Roger C, Weisman, Gary R, Toner, John L, Tarnowski, Thomas L, Chao, Y, Mayer, James M, Cram, Donald J

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Host-guest complexation. 13. High chiral recognition of amino esters by dilocular hosts containing extended steric barriers by Peacock, Stephen C, Domeier, Linda A, Gaeta, Fred C. A, Helgeson, Roger C, Timko, Joseph M, Cram, Donald J

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Synthesis and complexing properties of chiral macrocycles containing enforced cavities by Helgeson, Roger C, Mazaleyrat, Jean Paul, Cram, Donald J

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Host-guest complexation. 6. The [2.2]paracyclophanyl structural unit in host compounds by Helgeson, Roger C, Tarnowski, Thomas L, Timko, Joseph M, Cram, Donald J

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Stepwise Shell Closures Provide Hosts That Expose or Protect Guests from Outer-Phase Reactants by Kurdistani, Siavash K, Helgeson, Roger C, Cram, Donald J

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