Search Results - "Helge Martens, K."

Matrix metalloproteinase (MMP) induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke by Burggraf, Dorothe, Martens, Helge K, Dichgans, Martin, Hamann, Gerhard F

“…Although recombinant tissue plasminogen activator (rt-PA) is successfully used for thrombolysis in human stroke, it may increase the risk of haemorrhagic…”
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Recombinant human tissue plasminogen activator protects the basal lamina in experimental focal cerebral ischemia by Burggraf, Dorothe, Martens, Helge K, Jäger, Gabriele, Hamann, Gerhard F

“…While recombinant tissue plasminogen activator (rt-PA) is successfully used in human ischemic stroke, it may also cause hemorrhagic complications. Animal…”
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Tissue-saving infarct volumetry using histochemistry validated by MRI in rat focal ischemia by Kloss, Christian U.A., Thomassen, Nora, Fesl, Gunther, Helge Martens, K., Yousri, Tarek A., Hamann, Gerhard F.

“…Lesion size is an important outcome parameter in experimental stroke research. However, most methods of measuring the infarct volume in rodents either require…”
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Recombinant tissue plasminogen activator attenuates basal lamina antigen loss after experimental focal cerebral ischemia by Grobholz, Katharina, Burggraf, Dorothe, Martens, K. Helge, Wunderlich, Nathalie, Pichler, Matthias, Hamann, F. Gerhard

“…Background and purpose: The use of recombinant tissue plasminogen activator (rt-PA) is a proven therapy in acute stroke. Main concerns are based on hemorrhagic…”
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Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia by HAMANN, Gerhard F, BURGGRAF, Dorothe, MARTENS, Helge K, LIEBETRAU, Martin, JÄGER, Gabriele, WUNDERLICH, Nathalie, DEGEORGIA, Michael, KRIEGER, Derk W

“…Microvascular basal lamina damage occurs after cerebral ischemia and is important for the development of hemorrhage. The aim of this study was to determine…”
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rt-PA causes a dose-dependent increase in the extravasation of cellular and non-cellular blood elements after focal cerebral ischemia by Burggraf, Dorothe, Martens, Helge K, Dichgans, Martin, Hamann, Gerhard F

“…Abstract While recombinant tissue plasminogen activator (rt-PA) is successfully used for thrombolysis in human stroke, it may increase the risk of hemorrhagic…”
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Vascular integrin immunoreactivity is selectively lost on capillaries during rat focal cerebral ischemia and reperfusion by Burggraf, Dorothe, Trinkl, Andreas, Burk, Jan, Martens, Helge K, Dichgans, Martin, Hamann, Gerhard F

“…Abstract The α1-integrin cell adhesion molecules, the principal endothelial receptors for basal lamina (BL) components disappear during transient ischemia. The…”
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Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia by Burggraf, Dorothe, Liebetrau, Martin, Martens, Helge K., Wunderlich, Nathalie, Jäger, Gabriele, Dichgans, Martin, Hamann, Gerhard F.

“…Focal cerebral ischemia leads to the gradual disruption of the extracellular matrix. A key role in the turnover of the extracellular matrix is played by the…”
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Rt-PA causes a significant increase in endogenous u-PA during experimental focal cerebral ischemia by Burggraf, Dorothe, Martens, Helge K., Wunderlich, Nathalie, Jäger, Gabriele, Hamann, Gerhard F.

“…The aim of this study was to investigate the effects of different doses of exogenous recombinant human tissue plasminogen activator (rt‐PA) on the endogenous…”
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Delayed moderate hypothermia reduces calpain activity and breakdown of its substrate in experimental focal cerebral ischemia in rats by Liebetrau, Martin, Burggraf, Dorothe, Martens, Helge K., Pichler, Mathias, Hamann, Gerhard F.

“…Calpains, intracellular proteases, are involved in various cerebral disorders. To determine the effect of moderate hypothermia on calpain activity, transient…”
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A new approach to reduce the number of animals used in experimental focal cerebral ischemia models by Burggraf, Dorothe, Martens, Helge K., Liebetrau, Martin, Vosko, Milan R., Dichgans, Martin, Hamann, Gerhard F.

“…We describe a novel experimental set-up that allows biochemical, immunohistochemical and morphometric recording of multiple parameters from a single rat brain…”
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Hypothermia reduces influence of matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia by Burggraf, Dorothe, Martens, Helge K, Hamann, Gerhard F

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SHORT COMMUNICATION: Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia by Burggraf, Dorothe, Liebetrau, Martin, Martens, Helge K, Wunderlich, Nathalie, Jaeger, Gabriele, Dichgans, Martin, Hamann, Gerhard F

“…Focal cerebral ischemia leads to the gradual disruption of the extracellular matrix. A key role in the turnover of the extracellular matrix is played by the…”
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L-arginine-induced regional cerebral blood flow increase is abolished after transient focal cerebral ischemia in the rat by Sporer, B, Martens, K H, Koedel, U, Haberl, R L

“…We investigated the L-arginine-induced, regional cerebral blood flow (rCBF) enhancement after different durations of transient focal cerebral ischemia in the…”
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