Search Results - "Helge, Frieling"

Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies by Zindler, Tristan, Frieling, Helge, Neyazi, Alexandra, Bleich, Stefan, Friedel, Eva

“…Systematic technical effects--also called batch effects--are a considerable challenge when analyzing DNA methylation (DNAm) microarray data, because they can…”
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Structured neurological soft signs examination reveals motor coordination deficits in adults diagnosed with high-functioning autism by Wieting, Jelte, Baumann, Madita Vanessa, Deest-Gaubatz, Stephanie, Bleich, Stefan, Eberlein, Christian Karl, Frieling, Helge, Deest, Maximilian

“…Neurological soft signs (NSS), discrete deficits in motor coordination and sensory integration, have shown promise as markers in autism diagnosis. While motor…”
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Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study by Stapel, Britta, Fraccarollo, Daniela, Westhoff-Bleck, Mechthild, Bauersachs, Johann, Lichtinghagen, Ralf, Jahn, Kirsten, Burkert, Alexandra, Buchholz, Vanessa, Bleich, Stefan, Frieling, Helge, Ding, Xiao-Qi, Kahl, Kai G.

“…Major depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal…”
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A targeted long-read sequencing approach questions the association of OXTR methylation with high-functioning autism by Wieting, Jelte, Jahn, Kirsten, Bleich, Stefan, Frieling, Helge, Deest, Maximilian

“…DNA sequence variation and altered epigenetic regulation of the oxytocin receptor gene (OXTR) have been implicated in autism and autistic-like behaviors. While…”
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Chronic Voluntary Alcohol Consumption Alters Promoter Methylation and Expression of Fgf-2 and Fgfr1 by Herburg, Leonie, Rhein, Mathias, Kubinski, Sabrina, Kefalakes, Ekaterini, Levin Greenwald, Matar, Gielman, Simona, Barak, Segev, Frieling, Helge, Grothe, Claudia

“…Alcohol abuse accounts for 3.3 million deaths annually, rendering it a global health issue. Recently, fibroblast growth factor 2 (FGF-2) and its target,…”
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Psychopharmacological Treatment of Schizophrenia Over Time in 30 908 Inpatients: Data From the AMSP Study by Toto, Sermin, Grohmann, Renate, Bleich, Stefan, Frieling, Helge, Maier, Hannah B, Greil, Waldemar, Cordes, Joachim, Schmidt-Kraepelin, Christian, Kasper, Siegfried, Stübner, Susanne, Degner, Detlef, Druschky, Katrin, Zindler, Tristan, Neyazi, Alexandra

“…Psychotropic drugs are the cornerstone of schizophrenia treatment, often requiring lifelong treatment. Data on pharmacotherapy in inpatient settings are…”
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Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation by Pfisterer, Nina, Meyer-Bockenkamp, Fiona, Qu, Dong, Preuss, Vanessa, Rothämel, Thomas, Geisenberger, Dorothee, Läer, Katharina, Vennemann, Benedikt, Albers, Anne, Engelmann, Theresa A., Frieling, Helge, Rhein, Mathias, Klintschar, Michael

“…Background Based on findings in the brain stems of SIDS victims, the serotonin transporter (5-HTT) gene has been discussed to be associated with SIDS. Methods…”
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OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study by Reiner, Iris C., Gimpl, Gerald, Beutel, Manfred E., Bakermans-Kranenburg, Marian J., Frieling, Helge

“…We investigated stability and change of plasma and urinary oxytocin as well as OXTR DNA methylation patterns through psychotherapy. Furthermore, we explored…”
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Epigenetics in Personality Disorders: Today's Insights by Gescher, Dorothee Maria, Kahl, Kai G, Hillemacher, Thomas, Frieling, Helge, Kuhn, Jens, Frodl, Thomas

“…Epigenetic mechanisms have been described in several mental disorders, such as mood disorders, anxiety disorders and schizophrenia. However, less is known…”
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Aripiprazole treatment for temper outbursts in Prader–Willi syndrome by Deest, Maximilian, Wieting, Jelte, Jakob, Maximilian Michael, Deest-Gaubatz, Stephanie, Groh, Adrian, Seifert, Johanna, Toto, Sermin, Bleich, Stefan, Frieling, Helge, Eberlein, Christian K

“…Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder based on a loss of paternally expressed genes in chromosome segment 15q11-13. Behavioral…”
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Comparison of methylation estimates obtained via MinION nanopore sequencing and sanger bisulfite sequencing in the TRPA1 promoter region by Gombert, Sara, Jahn, Kirsten, Pathak, Hansi, Burkert, Alexandra, Schmidt, Gunnar, Wiehlmann, Lutz, Davenport, Colin, Brändl, Björn, Müller, Franz-Josef, Leffler, Andreas, Deest, Maximilian, Frieling, Helge

“…Bisulfite sequencing has long been considered the gold standard for measuring DNA methylation at single CpG resolution. However, in recent years several new…”
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Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment by Engelmann, Jan, Wagner, Stefanie, Wollschläger, Daniel, Kaaden, Sabine, Schlicht, Konrad F., Dreimüller, Nadine, Braus, Dieter F., Müller, Marianne B., Tüscher, Oliver, Frieling, Helge, Tadić, André, Lieb, Klaus

“…One important symptom of patients with major depressive disorder (MDD) is memory dysfunction. However, little is known about the relationship between memory…”
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Generation of an induced pluripotent stem cell line, ZIPi021-A, from fibroblasts of a Prader-Willi syndrome patient with maternal uniparental disomy (mUPD) by Heseding, Hannah, Jahn, Kirsten, Brändl, Björn, Haase, Alexandra, Shum, Ian O., Kohrn, Tim, Bleich, Stefan, Frieling, Helge, Martin, Ulrich, Müller, Franz-Josef, Wunderlich, Stephanie, Deest, Maximilian

“…Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of paternal expression of imprinted genes on chromosome 15q11-q13. We established a…”
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Bifrontal electroconvulsive therapy leads to improvement of cerebral glucose hypometabolism in frontotemporal dementia with comorbid psychotic depression - a case report by Schröder, Sebastian, Bönig, Lena, Proskynitopoulos, Phileas Johannes, Janke, Eva, Heck, Johannes, Mahmoudi, Nima, Groh, Adrian, Berding, Georg, Wedegärtner, Felix, Deest-Gaubatz, Stephanie, Maier, Hannah Benedictine, Bleich, Stefan, Frieling, Helge, Schulze Westhoff, Martin

“…Differentiating depression and dementia in elderly patients represents a major clinical challenge for psychiatrists. Pharmacological and non-pharmacological…”
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Dysregulated Methylation Patterns in Exon IV of the Brain-Derived Neurotrophic Factor (BDNF) Gene in Nicotine Dependence and Changes in BDNF Plasma Levels During Smoking Cessation by Abdelkhalek, Kerim, Rhein, Mathias, Deest, Maximilian, Buchholz, Vanessa, Bleich, Stefan, Lichtinghagen, Ralf, Vyssoki, Benjamin, Frieling, Helge, Muschler, Marc, Proskynitopoulos, Phileas Johannes, Glahn, Alexander

“…IntroductionSeveral studies reported dysregulated protein levels of brain-derived neurotrophic factor (BDNF) in smokers and during cessation. However, the…”
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BDNF Plasma Levels and BDNF Exon IV Promoter Methylation as Predictors for Antidepressant Treatment Response by Lieb, Klaus, Dreimüller, Nadine, Wagner, Stefanie, Schlicht, Konrad, Falter, Tanja, Neyazi, Alexandra, Müller-Engling, Linda, Bleich, Stefan, Tadić, André, Frieling, Helge

“…Major problems of current antidepressant pharmacotherapy are insufficient response rates and difficulties in response prediction. We recently provided…”
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Treating schizophrenia with cariprazine: from clinical research to clinical practice. Real world experiences and recommendations from an International Panel by Fagiolini, Andrea, Alcalá, José Ángel, Aubel, Thomas, Bienkiewicz, Wojciech, Bogren, Mats Magnus Knut, Gago, Joaquim, Cerveri, Giancarlo, Colla, Michael, Sanchez, Francisco Collazos, Cuomo, Alessandro, Helge, Frieling, Iacoponi, Eduardo, Karlsson, Per-Axel, Peddu, Pradeep, Pettorruso, Mauro, Pereira, Henrique Jorge Ramos, Schölin, Johan Sahlsten, Vernaleken, Ingo Bernd

“…Management of schizophrenia is sub-optimal in many patients. Targeting negative symptoms, among the most debilitating aspects of schizophrenia, together with…”
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Limitations of lymphoblastoid cell lines for functional analysis of SNPs by Pathak, Hansi, Frieling, Helge, Rhein, Mathias, Burkert, Alexandra

“…Single nucleotide polymorphisms (SNPs) are widely linked to the susceptibility and penetrance of diseases. SNP rs886205 (A/G) located in the aldehyde…”
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Autoantibody-associated psychiatric symptoms and syndromes in adults: A narrative review and proposed diagnostic approach by Hansen, Niels, Lipp, Michael, Vogelgsang, Jonathan, Vukovich, Ruth, Zindler, Tristan, Luedecke, Daniel, Gingele, Stefan, Malchow, Berend, Frieling, Helge, Kühn, Simone, Denk, Johannes, Gallinat, Jürgen, Skripuletz, Thomas, Moschny, Nicole, Fiehler, Jens, Riedel, Christian, Wiedemann, Klaus, Wattjes, Mike P., Zerr, Inga, Esselmann, Hermann, Bleich, Stefan, Wiltfang, Jens, Neyazi, Alexandra

“…Autoimmune-mediated encephalitis is a disease that often encompasses psychiatric symptoms as its first clinical manifestation’s predominant and isolated…”
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Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats by Helgers, Simeon O. A., Angelov, Svilen, Muschler, Marc A. N., Glahn, Alexander, Al-Afif, Shadi, Al Krinawe, Yazeed, Hermann, Elvis J., Krauss, Joachim K., Frieling, Helge, Schwabe, Kerstin, Rhein, Mathias

“…Structural and functional abnormalities in the cerebellar midline region, including the fastigial nucleus, have been reported in neuropsychiatric disorders,…”
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