Search Results - "Helfrich, Eric J. N"

Biosynthesis of polyketides by trans-AT polyketide synthases by Helfrich, Eric J N, Piel, Jörn

“…This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes…”
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Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering by Helfrich, Eric J N, Lin, Geng-Min, Voigt, Christopher A, Clardy, Jon

“…Terpenoids are the largest and structurally most diverse class of natural products. They possess potent and specific biological activity in multiple assays and…”
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Chromosome-level genome assembly of the sacoglossan sea slug Elysia timida (Risso, 1818) by Männer, Lisa, Schell, Tilman, Spies, Julia, Galià-Camps, Carles, Baranski, Damian, Ben Hamadou, Alexander, Gerheim, Charlotte, Neveling, Kornelia, Helfrich, Eric J N, Greve, Carola

“…Sequencing and annotating genomes of non-model organisms helps to understand genome architecture, the genetic processes underlying species traits, and how…”
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Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria by Helfrich, Eric J. N., Ueoka, Reiko, Chevrette, Marc G., Hemmerling, Franziska, Lu, Xiaowen, Leopold-Messer, Stefan, Minas, Hannah A., Burch, Adrien Y., Lindow, Steven E., Piel, Jörn, Medema, Marnix H.

“…Trans -acyltransferase polyketide synthases ( trans -AT PKSs) are bacterial multimodular enzymes that biosynthesize diverse pharmaceutically and ecologically…”
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Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A by Ndukwe, Ikenna E, Wang, Xiao, Lam, Nelson Y S, Ermanis, Kristaps, Alexander, Kelsey L, Bertin, Matthew J, Martin, Gary E, Muir, Garrett, Paterson, Ian, Britton, Robert, Goodman, Jonathan M, Helfrich, Eric J N, Piel, Jörn, Gerwick, William H, Williamson, R Thomas

“…Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly…”
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Hidden Treasures: Microbial Natural Product Biosynthesis off the Beaten Path by Biermann, Friederike, Helfrich, Eric J N

“…Microbes produce structurally diverse natural products to interact with their environment. Many of the biosynthetic products involved in this "metabolic small…”
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RAIChU: automating the visualisation of natural product biosynthesis by Terlouw, Barbara R., Biermann, Friederike, Vromans, Sophie P. J. M., Zamani, Elham, Helfrich, Eric J. N., Medema, Marnix H.

“…Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and…”
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In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids by Schleyer, Guy, Shahaf, Nir, Ziv, Carmit, Dong, Yonghui, Meoded, Roy A., Helfrich, Eric J. N., Schatz, Daniella, Rosenwasser, Shilo, Rogachev, Ilana, Aharoni, Asaph, Piel, Jörn, Vardi, Assaf

“…Tapping into the metabolic crosstalk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process…”
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Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis by Fukuda, Taise T. H, Helfrich, Eric J. N, Mevers, Emily, Melo, Weilan G. P, Van Arnam, Ethan B, Andes, David R, Currie, Cameron R, Pupo, Monica T, Clardy, Jon

“…Fungus-growing ants engage in a multilateral symbiosis: they cultivate a fungal garden as their primary food source and host symbiotic actinobacteria…”
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Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A by Reisberg, Solomon H, Gao, Yang, Walker, Allison S, Helfrich, Eric J N, Clardy, Jon, Baran, Phil S

“…Molecular shape defines function in both biological and material settings, and chemists have developed an ever-increasing vernacular to describe these shapes…”
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Automated structure prediction of trans-acyltransferase polyketide synthase products by Helfrich, Eric J. N., Ueoka, Reiko, Dolev, Alon, Rust, Michael, Meoded, Roy A., Bhushan, Agneya, Califano, Gianmaria, Costa, Rodrigo, Gugger, Muriel, Steinbeck, Christoph, Moreno, Pablo, Piel, Jörn

“…Bacterial trans -acyltransferase polyketide synthases ( trans -AT PKSs) are among the most complex known enzymes from secondary metabolism and are responsible…”
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Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges by Lackner, Gerald, Peters, Eike Edzard, Helfrich, Eric J. N., Piel, Jörn

“…The as-yet uncultured filamentous bacteria “Candidatus Entotheonella factor” and “Candidatus Entotheonella gemina” live associated with the marine sponge…”
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Pyonitrins A–D: Chimeric Natural Products Produced by Pseudomonas protegens by Mevers, Emily, Saurí, Josep, Helfrich, Eric J. N, Henke, Matthew, Barns, Kenneth J, Bugni, Tim S, Andes, David, Currie, Cameron R, Clardy, Jon

“…Bacterial symbionts frequently provide chemical defenses for their hosts, and such systems can provide discovery pathways to new antifungals and structurally…”
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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms by Ueoka, Reiko, Uria, Agustinus R, Reiter, Silke, Mori, Tetsushi, Karbaum, Petra, Peters, Eike E, Helfrich, Eric J N, Morinaka, Brandon I, Gugger, Muriel, Takeyama, Haruko, Matsunaga, Shigeki, Piel, Jörn

“…Investigations into the biosynthetic pathways of three families of actin-targeting macrolides lead to insights into their convergent or combinatorial…”
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Metabolic footprint of epiphytic bacteria on Arabidopsis thaliana leaves by Ryffel, Florian, Helfrich, Eric JN, Kiefer, Patrick, Peyriga, Lindsay, Portais, Jean-Charles, Piel, Jörn, Vorholt, Julia A

“…The phyllosphere, which is defined as the parts of terrestrial plants above the ground, is a large habitat for different microorganisms that show a high extent…”
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An environmental bacterial taxon with a large and distinct metabolic repertoire by Wilson, Micheal C., Mori, Tetsushi, Rückert, Christian, Uria, Agustinus R., Helf, Maximilian J., Takada, Kentaro, Gernert, Christine, Steffens, Ursula A. E., Heycke, Nina, Schmitt, Susanne, Rinke, Christian, Helfrich, Eric J. N., Brachmann, Alexander O., Gurgui, Cristian, Wakimoto, Toshiyuki, Kracht, Matthias, Crüsemann, Max, Hentschel, Ute, Abe, Ikuro, Matsunaga, Shigeki, Kalinowski, Jörn, Takeyama, Haruko, Piel, Jörn

“…Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such ‘talented’ producers represent…”
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Recent advances in genome-based polyketide discovery by Helfrich, Eric JN, Reiter, Silke, Piel, Jörn

“…Graphical abstract…”
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Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme by Liaimer, Anton, Helfrich, Eric J N, Hinrichs, Katrin, Guljamow, Arthur, Ishida, Keishi, Hertweck, Christian, Dittmann, Elke

“…Nostoc punctiforme is a versatile cyanobacterium that can live either independently or in symbiosis with plants from distinct taxa. Chemical cues from plants…”
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An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA by Smith, Duncan R. M, Uria, Agustinus R, Helfrich, Eric J. N, Milbredt, Daniela, van Pée, Karl-Heinz, Piel, Jörn, Goss, Rebecca J. M

“…Uncultured bacteria from sponges have been demonstrated to be responsible for the generation of many potent, bioactive natural products including halogenated…”
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Research Tales from the Clardy Laboratory: Function-Driven Natural Product Discovery by Fukuda, Taise T. H, Cassilly, Chelsi D, Gerdt, Joseph P, Henke, Matthew T, Helfrich, Eric J. N, Mevers, Emily

“…Over the past 70 years, the search for small molecules from nature has transformed biomedical research: natural products are the basis for half of all…”
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