Search Results - "Helfrich, BA"

EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines by Weiss, G.J., Bemis, L.T., Nakajima, E., Sugita, M., Birks, D.K., Robinson, W.A., Varella-Garcia, M., Bunn, P.A., Haney, J., Helfrich, B.A., Kato, H., Hirsch, F.R., Franklin, W.A.

“…Allelic loss in chromosome 3p is one of the most frequent and earliest genetic events in lung carcinogenesis. We investigated if the loss of microRNA-128b, a…”
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A High-Yielding Supramolecular Reaction by Aakeröy, Christer B, Beatty, Alicia M, Helfrich, Brian A

“…The X-ray crystal structure determinations of twelve cocrystals involving iso-nicotinamide and a variety of carboxylic acids have revealed a very consistent…”
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"Total Synthesis" Supramolecular Style: Design and Hydrogen-Bond-Directed Assembly of Ternary Supermolecules by Aakeröy, Christer B., Beatty, Alicia M., Helfrich, Brian A.

“…Getting the right balance between intermolecular interactions is crucial for the synthesis of supermolecules in a preconceived manner. The three‐component…”
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Do Polymorphic Compounds Make Good Cocrystallizing Agents? A Structural Case Study that Demonstrates the Importance of Synthon Flexibility by Aakeröy, Christer B, Beatty, Alicia M, Helfrich, Brian A, Nieuwenhuyzen, Mark

“…The ability of four polymorphic compounds, isonicotinamide (1), 2-amino-3-nitropyridine (2), 4-chlorobenzamide (3), and maleic hydrazide (4), to form molecular…”
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Epidermal growth factor receptor family in lung cancer and premalignancy by Franklin, Wilbur A, Veve, Robert, Hirsch, Fred R, Helfrich, Barbara A, Bunn, Paul A

“…Lung cancer, like many other epithelial malignancies, is thought to be the outcome of genetic and epigenetic changes that result in a constellation of…”
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PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines by Nakachi, I, Helfrich, BA, Spillman, MA, Mickler, EA, Olson, CJ, Rice, JL, Coldren, CD, Heasley, LE, Geraci, MW, Stearman, RS

“…Src kinase is recognized as a key target for molecular cancer therapy. However, methods to efficiently select patients responsive to Src inhibitors are…”
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ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non–small cell lung cancer by Raben, David, Helfrich, Barbara A., Chan, Dan, Johnson, Gary, Bunn, Paul A.

“…The epidermal growth factor receptor is overexpressed in a majority of non–small cell lung cancers and has been associated with a poor prognosis. Preclinical…”
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Metal-Containing Dicarboxylic Acids as Building Blocks for Lamellar Inorganic−Organic Hybrid Networks by Beatty, Alicia M, Helfrich, Brian A, Hogan, Greg A, Reed, Beth Ann

“…The synthesis of two transition-metal-containing dicarboxylic acids, and their use as starting materials in the supramolecular synthesis of eight different…”
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Syntheses and Bioactivities of Substituted 9,10-Dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual Reactivities with Amines by Hua, Duy H, Tamura, Masafumi, Huang, Xiaodong, Stephany, Heidi A, Helfrich, Brian A, Perchellet, Elisabeth M, Sperfslage, Bonnie J, Perchellet, Jean-Pierre, Jiang, Suping, Kyle, Dennis E, Chiang, Peter K

“…A number of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones have been synthesized and their anticancer and antimalarial activities…”
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Intramolecular Hydrogen Bonding and Intermolecular Dimerization in the Crystal Structures of Imidazole-4,5-dicarboxylic Acid Derivatives by Baures, Paul W, Rush, Jeremy R, Wiznycia, Alexander V, Desper, John, Helfrich, Brian A, Beatty, Alicia M

“…Diamide and amide-ester derivatives of imidazole-4,5-dicarboxylic acid form reliable hydrogen-bonding motifs in the solid state. The crystal structures of…”
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Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo by P A Bunn, Jr, B A Helfrich, D G Brenner, D C Chan, D J Dykes, A J Cohen, Y E Miller

“…Many lung cancers are stimulated by an autocrine/paracrine system of neuroendocrine peptide hormones. Attempts to block this autocrine growth pathway by…”
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Induction of human lymphokine-activated killer cells by IFN-alpha and IFN-gamma by Ellis, TM, McKenzie, RS, Simms, PE, Helfrich, BA, Fisher, RI

“…By traditional definitions, NK cells can be activated by cytokines to exhibit two functionally distinct levels of cytotoxicity. Whereas IL-2-mediated…”
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Identification of a novel CD56 super(-) lymphokine-activated killer cell precursor in cancer patients receiving recombinant interleukin 2 by McKenzie, R S, Simms, P E, Helfrich, BA, Fisher, R I, Ellis, T M

“…Circulating lymphokine-activated killer (LAK) cell activity in cancer patients receiving recombinant interleukin 2 (rIL-2) therapy is confined to cells…”
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Identification of a novel CD56- lymphokine-activated killer cell precursor in cancer patients receiving recombinant interleukin 2 by MCKENZIE, R. S, SIMMS, P. E, HELFRICH, B. A, FISHER, R. I, ELLIS, T. M

“…Circulating lymphokine-activated killer (LAK) cell activity in cancer patients receiving recombinant interleukin 2 (rIL-2) therapy is confined to cells…”
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Age-related changes in the degeneracy of the mouse T-cell repertoire by Helfrich, B A, Segre, M, Segre, D

“…Aging is associated with a decline in T-cell-dependent immune responses. As the number of T-cells remains relatively constant throughout life, the observed…”
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