Search Results - "Helfand, S.L"

Sir2 mediates longevity in the fly through a pathway related to calorie restriction by Rogina, B, Helfand, S.L

“…Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly…”
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans by Wood, J.G, Rogina, B, Lavu, S, Howitz, K, Helfand, S.L, Tatar, M, Sinclair, D

“…Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the…”
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accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster by Bauer, J.H, Goupil, S, Garber, G.B, Helfand, S.L

“…Recent advances in aging research have uncovered genes and genetic pathways that influence lifespan in such diverse organisms as yeast, nematodes, flies, and…”
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ACTIVATION OF TRANSPOSABLE ELEMENTS AS A MOLECULAR CAUSE OF AGING by Helfand, S.L., Wood, J., Jones, B.C., Taylor, J.

“…Transposable Elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of…”
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Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies by Marden, J.H, Rogina, B, Montooth, K.L, Helfand, S.L

“…Alterations that extend the life span of animals and yeast typically involve decreases in metabolic rate, growth, physical activity, and/or early-life…”
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Segmental distribution of bithorax complex proteins during Drosophila development by Beachy, P.A, Helfand, S.L, Hogness, D.S

“…The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and…”
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Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster by Helfand, S.L. (University of Connecticut Health Center, Farmington, CT.), Blake, K.J, Rogina, B, Stracks, M.D, Centurion, A, Naprta, B

“…The time course of gene expression in the adult fruit fly has been partially characterized by using enhancer trap and reporter gene constructs that mark 49…”
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Regulation of gene expression is linked to life span in adult Drosophila by Rogina, B. (University of Connecticut Health Center, Farmington, CT.), Helfand, S.L

“…Examination of gene expression and aging in adult Drosophila reveals that the expression of some genes is regulated by age-dependent mechanisms. Genetic…”
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Timing of expression of a gene in the adult Drosophila is regulated by mechanisms independent of temperature and metabolic rate by Rogina, B, Helfand, S.L

“…The examination of beta-galactosidase (beta-gal) expression in the third segment of the antenna of the 2216 enhancer trap line in Drosophila melanogaster…”
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The large upstream control region of the Drosophila homeotic gene Ultrabithorax by IRVINE, K. D, HELFAND, S. L, HOGNESS, D. S

“…Ultrabithorax (Ubx) is a Drosophila homeotic gene that determines the segmental identities of parts of the thorax and abdomen. Appropriate Ubx transcription…”
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Genetic analysis of olfactory behavior in Drosophila: a new screen yields the ota mutants by Woodard, C. (Yale University, New Haven, CT), Huang, T, Sun, H, Helfand, S.L, Carlson, J

“…A simple means of measuring Drosophila olfactory response is described, and the behavior which it measures is characterized. The assay was used to screen for…”
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A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected by McKenna, M. (Yale University, New Haven, CT), Monte, P, Helfand, S.L, Woodard, C, Carlson, J

“…Although the Drosophila visual system has been described extensively, little is known about its olfactory system. A major reason for this discrepancy has been…”
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Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect by Helfand, Stephen L., Carlson, John R.

“…A Drosophila mutant was isolated and shown to exhibit defective response to the chemical odorant benzaldehyde in two distinctly different behavioral assays…”
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Regulation and products of the Ubx domain of the bithorax complex by Hogness, D S, Lipshitz, H D, Beachy, P A, Peattie, D A, Saint, R B, Goldschmidt-Clermont, M, Harte, P J, Gavis, E R, Helfand, S L

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Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia by Helfand, Stephen L., Smith, Gary A., Wessells, Norman K.

“…Parasympathetic neurons from avian embryonic ciliary ganglia survive in low density culture when neurons are free from contact with other cells. A charged…”
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A molecular marker confirms that the rate of adult maturation is largely independent of the rate of pre-adult development in Drosophila melanogaster by Blake, Kimberly J., Hoopengardner, Barry, Centurion, Alejandro, Helfand, Stephen L.

“…The separation of adult from pre-adult life seen with animals such as Drosophila melanogaster, which are holometabolous and undergo complete metamorphosis,…”
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