Search Results - "Heldin, CH"

Oral imatinib mesylate (STI571/Gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits by LEPPÄNEN, Olli, RUTANEN, Juha, BERGQVIST, David, ALITALO, Kari, HELDIN, Carl-Henrik, ÖSTMAN, Arne, YLÄ-HERTTUALA, Seppo, HILTUNEN, Mikko O, RISSANEN, Tuomas T, TURUNEN, Mikko P, SJÖBLOM, Tobias, BRÜGGEN, Josef, BÄCKSTRÖM, Gudrun, CARLSSON, Marianne, BUCHDUNGER, Elisabeth

“…Platelet-derived growth factor (PDGF) antagonists have demonstrated beneficial effects on neointima formation, but in studies using PDGF inhibitors and…”
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Non-Smad TGF-beta signals by Moustakas, Aristidis, Heldin, Carl-Henrik

“…During the past 10 years, it has been firmly established that Smad pathways are central mediators of signals from the receptors for transforming growth factor…”
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High interstitial fluid pressure - an obstacle in cancer therapy by Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne

“…Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in…”
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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition by Valcourt, Ulrich, Kowanetz, Marcin, Niimi, Hideki, Heldin, Carl-Henrik, Moustakas, Aristidis

“…Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and carcinoma invasiveness. We show that transforming growth factor…”
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Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein by Taipale, J, Miyazono, K, Heldin, C H, Keski-Oja, J

“…The role of latent transforming growth factor-beta (TGF-beta) binding protein (LTBP) in the association of TGF-beta 1 to the extracellular matrix of cultured…”
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Transforming growth factor-β employs HMGA2 to elicit epithelial-mesenchymal transition by Thuault, Sylvie, Valcourt, Ulrich, Petersen, Maj, Manfioletti, Guidalberto, Heldin, Carl-Henrik, Moustakas, Aristidis

“…Epithelial-mesenchymal transition (EMT) occurs during embryogenesis, carcinoma invasiveness, and metastasis and can be elicited by transforming growth factor-β…”
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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis by Zhang, Yanyu, Cedervall, Jessica, Hamidi, Anahita, Herre, Melanie, Viitaniemi, Kati, D'Amico, Gabriela, Miao, Zuoxiu, Unnithan, Ragaseema Valsala Madhavan, Vaccaro, Alessandra, van Hooren, Luuk, Georganaki, Maria, Thulin, Åsa, Qiao, Qi, Andrae, Johanna, Siegbahn, Agneta, Heldin, Carl-Henrik, Alitalo, Kari, Betsholtz, Christer, Dimberg, Anna, Olsson, Anna-Karin

“…Platelet-derived growth factor B (PDGFB) plays a crucial role in recruitment of PDGF receptor β-positive pericytes to blood vessels. The endothelium is an…”
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Dynamic control of TGF-β signaling and its links to the cytoskeleton by Moustakas, Aristidis, Heldin, Carl-Henrik

“…Transforming growth factor β (TGF-β) regulates cellular behavior in embryonic and adult tissues. TGF-β binding to serine/threonine kinase receptors on the…”
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Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification by Vanlandewijck, Michael, Lebouvier, Thibaud, Andaloussi Mäe, Maarja, Nahar, Khayrun, Hornemann, Simone, Kenkel, David, Cunha, Sara I, Lennartsson, Johan, Boss, Andreas, Heldin, Carl-Henrik, Keller, Annika, Betsholtz, Christer

“…Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by progressive pericapillary calcifications, has recently been linked to…”
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PDGF receptors as cancer drug targets by Pietras, Kristian, Sjöblom, Tobias, Rubin, Kristofer, Heldin, Carl-Henrik, Östman, Arne

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Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer by Paulsson, Janna, Sjöblom, Tobias, Micke, Patrick, Pontén, Fredrik, Landberg, Göran, Heldin, Carl-Henrik, Bergh, Jonas, Brennan, Donal J, Jirström, Karin, Östman, Arne

“…This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations…”
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Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor by Heldin, Carl-Henrik, Westermark, Bengt

“…Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden Heldin, Carl-Henrik and Bengt…”
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Smad regulation in TGF-beta signal transduction by Moustakas, A, Souchelnytskyi, S, Heldin, C H

“…Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands that regulate cell proliferation, differentiation and death…”
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PDGF and vessel maturation by Hellberg, Carina, Ostman, Arne, Heldin, C-H

“…Pericytes are smooth muscle-like cells found in close contact with the endothelium in capillaries, where they regulate the morphology and function of the…”
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The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma by Caja, Laia, Dadras, Mahsa Shahidi, Mezheyeuski, Artur, Rodrigues‐Junior, Dorival Mendes, Liu, Sijia, Webb, Anna Taylor, Gomez‐Puerto, Maria Catalina, ten Dijke, Peter, Heldin, Carl‐Henrik, Moustakas, Aristidis

“…The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to…”
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2R and remodeling of vertebrate signal transduction engine by Huminiecki, Lukasz, Heldin, Carl Henrik

“…Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through…”
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PDGF Receptors as Targets in Tumor Treatment by Östman, Arne, Heldin, Carl‐Henrik

“…Signaling through platelet‐derived growth factor (PDGF) receptors contributes to multiple tumor‐associated processes. The recent introduction of clinically…”
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Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis by Cunha, Sara I, Pardali, Evangelia, Thorikay, Midory, Anderberg, Charlotte, Hawinkels, Lukas, Goumans, Marie-José, Seehra, Jasbir, Heldin, Carl-Henrik, ten Dijke, Peter, Pietras, Kristian

“…Members of the transforming growth factor beta (TGF-beta) family have been genetically linked to vascular formation during embryogenesis. However,…”
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Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA by Edlund, Sofia, Landström, Maréne, Heldin, Carl-Henrik, Aspenström, Pontus

“…Transforming growth factor-beta (TGF-beta) is a potent regulator of cell growth and differentiation in many cell types. The Smad signaling pathway constitutes…”
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Mechanisms of TGF-β signaling in regulation of cell growth and differentiation by Moustakas, Aristidis, Pardali, Katerina, Gaal, Annamaria, Heldin, Carl-Henrik

“…Transforming growth factor β (TGF-β) is a secreted protein that regulates proliferation, differentiation and death of various cell types. All immune cell…”
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