Search Results - "Heldens, Lonneke"

Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels by Hensen, Sanne M.M., Heldens, Lonneke, van Enckevort, Chrissy M.W., van Genesen, Siebe T., Pruijn, Ger J.M., Lubsen, Nicolette H.

“…In cells starved for leucine, lysine or glutamine heat shock factor 1 (HSF1) is inactivated and the level of the transcripts of the HSF1 target genes HSPA1A…”
Get full text

An atypical unfolded protein response in heat shocked cells by Heldens, Lonneke, Hensen, Sanne M M, Onnekink, Carla, van Genesen, Siebe T, Dirks, Ron P, Lubsen, Nicolette H

“…The heat shock response (HSR) and the unfolded protein response (UPR) are both activated by proteotoxic stress, although in different compartments, and share…”
Get full text

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8 by Morelli, Federica F., Mediani, Laura, Heldens, Lonneke, Bertacchini, Jessika, Bigi, Ilaria, Carrà, Arianna Dorotea, Vinet, Jonathan, Carra, Serena

“…The ten mammalian small heat shock proteins (sHSPs/HSPBs) show a different expression profile, although the majority of them are abundant in skeletal and…”
Get full text

Heat shock factor 1 is inactivated by amino acid deprivation by Hensen, Sanne M. M., Heldens, Lonneke, van Enckevort, Chrissy M. W., van Genesen, Siebe T., Pruijn, Ger J. M., Lubsen, Nicolette H.

“…Mammalian cells respond to a lack of amino acids by activating a transcriptional program with the transcription factor ATF4 as one of the main actors. When…”
Get full text

Co-chaperones are limiting in a depleted chaperone network by Heldens, Lonneke, Dirks, Ron P, Hensen, Sanne M. M, Onnekink, Carla, van Genesen, Siebe T, Rustenburg, François, Lubsen, Nicolette H

“…To probe the limiting nodes in the chaperoning network which maintains cellular proteostasis, we expressed a dominant negative mutant of heat shock factor 1…”
Get full text

A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant by Hensen, Sanne M. M., Heldens, Lonneke, van Genesen, Siebe T., Pruijn, Ger J. M., Lubsen, Nicolette H.

“…To assess the consequences of inactivation of heat shock factor 1 (HSF1) during aging, we analyzed the effect of HSF1 K80Q, a mutant unable to bind DNA, and of…”
Get full text

Protein refolding in peroxisomes is dependent upon an HSF1-regulated function by Heldens, Lonneke, van Genesen, Siebe T., Hanssen, Lars L. P., Hageman, Jurre, Kampinga, Harm H., Lubsen, Nicolette H.

“…Post-heat shock refolding of luciferase requires chaperones. Expression of a dominant negative HSF1 mutant (dnHSF1), which among other effects depletes cells…”
Get full text

The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels by Meex, Steven J.R, Weissglas-Volkov, Daphna, van der Kallen, Carla J.H, Thuerauf, Donna J, van Greevenbroek, Marleen M.J, Schalkwijk, Casper G, Stehouwer, Coen D.A, Feskens, Edith J.M, Heldens, Lonneke, Ayoubi, Torik A, Hofker, Marten H, Wouters, Bradly G, Vlietinck, Robert, Sinsheimer, Janet S, Taskinen, Marja-Riitta, Kuusisto, Johanna, Laakso, Markku, de Bruin, Tjerk W.A, Pajukanta, Päivi, Glembotski, Christopher C

“…OBJECTIVE—Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic…”
Get full text

The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels : National Cholesterol Awareness Month by MEEX, Steven J. R, WEISSGLAS-VOLKOV, Daphna, HOFKER, Marten H, WOUTERS, Bradly G, VLIETINCK, Robert, SINSHEIMER, Janet S, TASKINEN, Marja-Riitta, KUUSISTO, Johanna, LAAKSO, Markku, DE BRUIN, Tjerk W. A, PAJUKANTA, Päivi, GLEMBOTSKI, Christopher C, VAN DER KALLEN, Carla J. H, THUERAUF, Donna J, VAN GREEVENBROEK, Marleen M. J, SCHALKWIJK, Casper G, STEHOUWER, Coen D. A, FESKENS, Edith J. M, HELDENS, Lonneke, AYOUBI, Torik A

Get full text