Search Results - "Held, Richard"

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function by Wang, Chih-Chieh, Held, Richard G., Chang, Shiao-Chi, Yang, Lingling, Delpire, Eric, Ghosh, Anirvan, Hall, Benjamin J.

“…The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated during cortical development. NMDARs are initially dominated by GluN2B…”
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Autism as a disorder of prediction by Sinha, Pawan, Kjelgaard, Margaret M., Gandhi, Tapan K., Tsourides, Kleovoulos, Cardinaux, Annie L., Pantazis, Dimitrios, Diamond, Sidney P., Held, Richard M.

“…A rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is…”
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Nanoscale architecture of synaptic vesicles and scaffolding complexes revealed by cryo-electron tomography by Held, Richard G, Liang, Jiahao, Brunger, Axel T

“…The spatial distribution of proteins and their arrangement within the cellular ultrastructure regulates the opening of…”
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SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks by Wang, Chih-Chieh, Held, Richard G, Hall, Benjamin J

“…Disrupting the balance between excitatory and inhibitory neurotransmission in the developing brain has been causally linked with intellectual disability (ID)…”
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Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking by Wang, Shan Shan H., Held, Richard G., Wong, Man Yan, Liu, Changliang, Karakhanyan, Aziz, Kaeser, Pascal S.

“…In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone. The active zone is a protein scaffold that is attached to the…”
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Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry by Held, Richard G., Liu, Changliang, Ma, Kunpeng, Ramsey, Austin M., Tarr, Tyler B., De Nola, Giovanni, Wang, Shan Shan H., Wang, Jiexin, van den Maagdenberg, Arn M.J.M., Schneider, Toni, Sun, Jianyuan, Blanpied, Thomas A., Kaeser, Pascal S.

“…Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First,…”
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Potential downside of high initial visual acuity by Vogelsang, Lukas, Gilad-Gutnick, Sharon, Ehrenberg, Evan, Yonas, Albert, Diamond, Sidney, Held, Richard, Sinha, Pawan

“…Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period…”
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ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains by Held, Richard G, Liu, Changliang, Kaeser, Pascal S

“…In a presynaptic nerve terminal, synaptic strength is determined by the pool of readily releasable vesicles (RRP) and the probability of release (P) of each…”
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ELKS active zone proteins as multitasking scaffolds for secretion by Held, Richard G., Kaeser, Pascal S.

“…Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of…”
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Structure and topography of the synaptic V-ATPase–synaptophysin complex by Wang, Chuchu, Jiang, Wenhong, Leitz, Jeremy, Yang, Kailu, Esquivies, Luis, Wang, Xing, Shen, Xiaotao, Held, Richard G., Adams, Daniel J., Basta, Tamara, Hampton, Lucas, Jian, Ruiqi, Jiang, Lihua, Stowell, Michael H. B., Baumeister, Wolfgang, Guo, Qiang, Brunger, Axel T.

“…Synaptic vesicles are organelles with a precisely defined protein and lipid composition 1 , 2 , yet the molecular mechanisms for the biogenesis of synaptic…”
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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein by Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J B, Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J, White, K Ian, Held, Richard G, Subramanian, Subu, Marcus, Kendra, Pfuetzner, Richard A, Esquivies, Luis, Doyle, Catherine A, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tom, Brunger, Axel T

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available coronavirus disease 2019 vaccines and monoclonal…”
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The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons by Liu, Changliang, Bickford, Lydia S, Held, Richard G, Nyitrai, Hajnalka, Südhof, Thomas C, Kaeser, Pascal S

“…In a presynaptic nerve terminal, synaptic vesicle exocytosis is restricted to specialized sites called active zones. At these sites, neurotransmitter release…”
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Astigmatism and the development of myopia in children by Gwiazda, Jane, Grice, Kenneth, Held, Richard, McLellan, James, Thorn, Frank

“…While it is now established that astigmatism is more prevalent in infants and young children than in the adult population, little is known about the functional…”
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The association of wavefront aberration and accommodative lag in myopes by He, Ji C., Gwiazda, Jane, Thorn, Frank, Held, Richard, Vera-Diaz, Fuensanta A.

“…Accommodative lags, induced by a target at 33 cm (distance-induced condition) and by a −3.0 D lens (lens-induced condition), and wavefront aberrations were…”
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A dynamic relationship between myopia and blur-driven accommodation in school-aged children by Gwiazda, J, Bauer, J, Thorn, F, Held, R

“…Previously we reported that recently myopic children accommodated insufficiently to blur induced by negative lenses. The purpose of the present study was to…”
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Visual-haptic mapping and the origin of cross-modal identity by Held, Richard

“…We found that congenitally blind people who gain sight initially fail to identify seen objects with their felt versions: a negative answer to the Molyneux…”
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Adapting to supernormal auditory localization cues. I. Bias and resolution by Shinn-Cunningham, B G, Durlach, N I, Held, R M

“…Head-related transfer functions (HRTFs) were used to create spatialized stimuli for presentation through earphones. Subjects performed forced-choice,…”
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A modular covalent labeling system for ground-truth localization of synaptic proteins by cryo-electron tomography by Held, Richard, Azubel, Maia, Liang, Jiahao, Brunger, Axel

“…Abstract only…”
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The newly sighted fail to match seen with felt by Held, Richard, Sinha, Pawan, Ostrovsky, Yuri, de Gelder, Beatrice, Gandhi, Tapan, Ganesh, Suma, Mathur, Umang

“…Would a blind subject, on regaining sight, be able to immediately visually recognize an object previously known only by touch? We addressed this question,…”
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Gravitoinertial Force Magnitude and Direction Influence Head-Centric Auditory Localization by DiZio, Paul, Held, Richard, Lackner, James R, Shinn-Cunningham, Barbara, Durlach, Nathaniel

“…  1 Ashton Graybiel Spatial Orientation Laboratory and Volen Center for Complex Systems, Brandeis University, Waltham 02454-9110;   2 Department of Brain and…”
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