Search Results - "Held, M"

Robust Responses of the Hydrological Cycle to Global Warming by Held, Isaac M., Soden, Brian J.

“…Using the climate change experiments generated for the Fourth Assessment of the Intergovernmental Panel on Climate Change, this study examines some aspects of…”
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An Assessment of Climate Feedbacks in Coupled Ocean–Atmosphere Models by Soden, Brian J., Held, Isaac M.

“…The climate feedbacks in coupled ocean–atmosphere models are compared using a coordinated set of twenty-first-century climate change experiments. Water vapor…”
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Mitochondrial quality control pathways as determinants of metabolic health by Held, Ntsiki M., Houtkooper, Riekelt H.

“…Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is associated with various pathologies, including inherited…”
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Fuel Estimation in Air Transportation: Modeling global fuel consumption for commercial aviation by Seymour, K., Held, M., Georges, G., Boulouchos, K.

“…[Display omitted] •We propose a novel framework for Fuel Estimation in Air Transportation (FEAT).•FEAT combines computational efficiency and accuracy of fuel…”
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Autism as a disorder of prediction by Sinha, Pawan, Kjelgaard, Margaret M., Gandhi, Tapan K., Tsourides, Kleovoulos, Cardinaux, Annie L., Pantazis, Dimitrios, Diamond, Sidney P., Held, Richard M.

“…A rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is…”
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Importance of Ocean Heat Uptake Efficacy to Transient Climate Change by Winton, Michael, Takahashi, Ken, Held, Isaac M.

“…This article proposes a modification to the standard forcing–feedback diagnostic energy balance model to account for 1) differences between effective and…”
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Beyond the Oberbeck–Boussinesq and long wavelength approximation by Held, M., Wiesenberger, M.

“…Abstract We present the first simulations of a reduced magnetized plasma model that incorporates both arbitrary wavelength polarization and…”
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TC-Permitting GCM Simulations of Hurricane Frequency Response to Sea Surface Temperature Anomalies Projected for the Late-Twenty-First Century by Zhao, Ming, Held, Isaac M.

“…A tropical cyclone–permitting global atmospheric model is used to explore the hurricane frequency response to sea surface temperature (SST) anomalies generated…”
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NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation by van der Post, Sjoerd, Birchenough, George M.H., Held, Jason M.

“…The colon epithelium is a primary point of interaction with the microbiome and is regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC…”
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Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry by Collins, Ben C., Hunter, Christie L., Liu, Yansheng, Schilling, Birgit, Rosenberger, George, Bader, Samuel L., Chan, Daniel W., Gibson, Bradford W., Gingras, Anne-Claude, Held, Jason M., Hirayama-Kurogi, Mio, Hou, Guixue, Krisp, Christoph, Larsen, Brett, Lin, Liang, Liu, Siqi, Molloy, Mark P., Moritz, Robert L., Ohtsuki, Sumio, Schlapbach, Ralph, Selevsek, Nathalie, Thomas, Stefani N., Tzeng, Shin-Cheng, Zhang, Hui, Aebersold, Ruedi

“…Quantitative proteomics employing mass spectrometry is an indispensable tool in life science research. Targeted proteomics has emerged as a powerful approach…”
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Simulations of Global Hurricane Climatology, Interannual Variability, and Response to Global Warming Using a 50-km Resolution GCM by Zhao, Ming, Held, Isaac M., Lin, Shian-Jiann, Vecchi, Gabriel A.

“…A global atmospheric model with roughly 50-km horizontal grid spacing is used to simulate the interannual variability of tropical cyclones using observed sea…”
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Large-scale control on the frequency of tropical cyclones and seeds: a consistent relationship across a hierarchy of global atmospheric models by Hsieh, Tsung-Lin, Vecchi, Gabriel A., Yang, Wenchang, Held, Isaac M., Garner, Stephen T.

“…A diagnostic framework is developed to explain the response of tropical cyclones (TCs) to climate in high-resolution global atmospheric models having different…”
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Probing the Fast and Slow Components of Global Warming by Returning Abruptly to Preindustrial Forcing by Held, Isaac M., Winton, Michael, Takahashi, Ken, Delworth, Thomas, Zeng, Fanrong, Vallis, Geoffrey K.

“…The fast and slow components of global warming in a comprehensive climate model are isolated by examining the response to an instantaneous return to…”
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Modeled Impact of Anthropogenic Warming on the Frequency of Intense Atlantic Hurricanes by Bender, Morris A, Knutson, Thomas R, Tuleya, Robert E, Sirutis, Joseph J, Vecchi, Gabriel A, Garner, Stephen T, Held, Isaac M

“…Several recent models suggest that the frequency of Atlantic tropical cyclones could decrease as the climate warms. However, these models are unable to…”
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Dynamical Downscaling Projections of Twenty-First-Century Atlantic Hurricane Activity: CMIP3 and CMIP5 Model-Based Scenarios by Knutson, Thomas R., Sirutis, Joseph J., Vecchi, Gabriel A., Garner, Stephen, Zhao, Ming, Kim, Hyeong-Seog, Bender, Morris, Tuleya, Robert E., Held, Isaac M., Villarini, Gabriele

“…Twenty-first-century projections of Atlantic climate change are downscaled to explore the robustness of potential changes in hurricane activity. Multimodel…”
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Quantifying Climate Feedbacks Using Radiative Kernels by Soden, Brian J., Held, Isaac M., Colman, Robert, Shell, Karen M., Kiehl, Jeffrey T., Shields, Christine A.

“…The extent to which the climate will change due to an external forcing depends largely on radiative feedbacks, which act to amplify or damp the surface…”
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Phase speed spectra and the recent poleward shift of Southern Hemisphere surface westerlies by Chen, Gang, Held, Isaac M.

“…The poleward shift of the Southern Hemisphere surface westerlies in recent decades is examined in reanalysis data and in the output of coupled atmosphere‐ocean…”
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways by Rardin, Matthew J., Newman, John C., Held, Jason M., Cusack, Michael P., Sorensen, Dylan J., Li, Biao, Schilling, Birgit, Mooney, Sean D., Kahn, C. Ronald, Verdin, Eric, Gibson, Bradford W.

“…Large-scale proteomic approaches have identified numerous mitochondrial acetylated proteins; however in most cases, their regulation by acetyltransferases and…”
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The Gap between Simulation and Understanding in Climate Modeling by Held, Isaac M.

“…The problem of creating truly convincing numerical simulations of our Earth's climate will remain a challenge for the next generation of climate scientists…”
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Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research by Chatzispyrou, Iliana A, Held, Ntsiki M, Mouchiroud, Laurent, Auwerx, Johan, Houtkooper, Riekelt H

“…Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF…”
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