Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy

Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour...

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Bibliographic Details
Published in:	Expert reviews in molecular medicine Vol. 26; p. e18
Main Authors:	Helal, Israa M, Kamal, Monica A, Abd El-Aziz, Mostafa K, El Tayebi, Hend M
Format:	Journal Article
Language:	English
Published:	England 25-09-2024
Subjects:	Animals Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Immunotherapy - methods Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - pathology Liver Neoplasms - therapy Tumor Microenvironment - immunology Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism hepatocellular carcinoma (HCC) macrophages epigenetics tumour-associated macrophages (TAMs) immunotherapy
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Summary:	Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour-associated macrophages (TAMs), one of the most dominant components in the tumour microenvironment, are recognized as anti-tumour suppressors. Unfortunately, the complete behaviour of TAMs is still unclear and understudied. TAM density is directly correlated with the progression and poor prognosis of hepatocellular carcinoma (HCC), therefore studying TAMs from different points of view passing by all the factors that may affect its existence, polarization, functions and repolarization are of great importance. Different epigenetic regulations were reported to have a direct relation with both HCC and TAMs. Here, this review discusses different epigenetic regulations that can affect TAMs in HCC whether positively or negatively.
ISSN:	1462-3994
DOI:	10.1017/erm.2024.9