Search Results - "Helán, Martin"

Phagocytosis–Inflammation Crosstalk in Sepsis: New Avenues for Therapeutic Intervention by Hortová-Kohoutková, Marcela, Tidu, Federico, De Zuani, Marco, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…ABSTRACTPhagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by…”
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High CD4‐to‐CD8 ratio identifies an at‐risk population susceptible to lethal COVID‐19 by De Zuani, Marco, Lazničková, Petra, Tomašková, Veronika, Dvončová, Martina, Forte, Giancarlo, Stokin, Gorazd Bernard, Šrámek, Vladimir, Helán, Martin, Frič, Jan

“…Around half of people with severe COVID‐19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS‐CoV‐2…”
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Human myeloid‐derived suppressor cell expansion during sepsis is revealed by unsupervised clustering of flow cytometric data by De Zuani, Marco, Hortová‐Kohoutková, Marcela, Andrejčinová, Ivana, Tomášková, Veronika, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…Myeloid‐derived suppressor cells (MDSCs) are important regulators of immune processes during sepsis in mice. However, confirming these observations in humans…”
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Hepcidin and ferritin levels as markers of immune cell activation during septic shock, severe COVID-19 and sterile inflammation by Hortová-Kohoutková, Marcela, Skotáková, Monika, Onyango, Isaac G, Slezáková, Miriam, Panovský, Roman, Opatřil, Lukáš, Slanina, Peter, De Zuani, Marco, Mrkva, Ondřej, Andrejčinová, Ivana, Lázničková, Petra, Dvončová, Martina, Mýtniková, Alexandra, Ostland, Vaughn, Šitina, Michal, Stokin, Gorazd B, Šrámek, Vladimír, Vlková, Marcela, Helán, Martin, Frič, Jan

“…Major clinically relevant inflammatory events such as septic shock and severe COVID-19 trigger dynamic changes in the host immune system, presenting promising…”
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Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis by Hortová-Kohoutková, Marcela, De Zuani, Marco, Lázničková, Petra, Bendíčková, Kamila, Mrkva, Ondřej, Andrejčinová, Ivana, Mýtniková, Alexandra, Polanský, Ondřej, Kočí, Kamila, Tomášková, Veronika, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…Sepsis and septic shock remain leading causes of morbidity and mortality for patients in the intensive care unit. During the early phase, immune cells produce…”
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Differences in monocyte subsets are associated with short‐term survival in patients with septic shock by Hortová‐Kohoutková, Marcela, Lázničková, Petra, Bendíčková, Kamila, De Zuani, Marco, Andrejčinová, Ivana, Tomášková, Veronika, Suk, Pavel, Šrámek, Vladimír, Helán, Martin, Frič, Jan

“…Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic…”
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Prognostic value of soluble endoglin in patients with septic shock and severe COVID-19 by Tomášková, Veronika, Mýtniková, Alexandra, Hortová Kohoutková, Marcela, Mrkva, Ondřej, Skotáková, Monika, Šitina, Michal, Helánová, Kateřina, Frič, Jan, Pařenica, Jiří, Šrámek, Vladimír, Helán, Martin

“…Sepsis is a clinical syndrome characterized by a dysregulated response to infection. It represents a leading cause of mortality in ICU patients worldwide…”
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Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development by Andrejčinová, Ivana, Blažková, Gabriela, Papatheodorou, Ioanna, Bendíčková, Kamila, Bosáková, Veronika, Skotáková, Monika, Panovský, Roman, Opatřil, Lukáš, Vymazal, Ondřej, Kovačovicová, Petra, Šrámek, Vladimír, Helán, Martin, Hortová-Kohoutková, Marcela, Frič, Jan

“…COVID-19 manifestation is associated with a strong immune system activation leading to inflammation and subsequently affecting the cardiovascular system. The…”
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Ischaemic Stroke Caused by a Gunshot Wound to the Chest by Helán, Martin, Ráb, Martin, Šrámek, Vladimír, Vaníček, Jiří, Staffa, Robert, Volný, Ondřej, Suk, Pavel

“…Pneumatic weapons rarely cause severe trauma. However, pellet embolisation can cause severe and unexpected injuries. This is the case study of a 32 year old…”
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Impact of contralateral carotid stenosis on brain tissue oxygenation during carotid endarterectomy by Lukeš, Marek, Helán, Martin, Šrámek, Vladimír, Pavlíková, Jana, Staffa, Robert, Suk, Pavel

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Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis by Sitina, Michal, Sramek, Vladimir, Helan, Martin, Suk, Pavel

“…Acute kidney injury (AKI) is associated with impaired outcomes in critically ill COVID-19 patients. However, the prognostic significance of early AKI is poorly…”
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BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia by Helan, Martin, Aravamudan, Bharathi, Hartman, William R, Thompson, Michael A, Johnson, Bruce D, Pabelick, Christina M, Prakash, Y.S

“…Abstract Within human pulmonary artery, neurotrophin growth factors [NTs; e.g. brain-derived neurotrophic factor (BDNF)] and their high-affinity receptors…”
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Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle by Hartman, William, Helan, Martin, Smelter, Dan, Sathish, Venkatachalem, Thompson, Michael, Pabelick, Christina M, Johnson, Bruce, Prakash, Y S

“…Hypoxia effects on pulmonary artery structure and function are key to diseases such as pulmonary hypertension. Recent studies suggest that growth factors…”
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Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study by Helan, Martin, Malaska, Jan, Tomandl, Josef, Jarkovsky, Jiri, Helanova, Katerina, Benesova, Klara, Sitina, Michal, Dastych, Milan, Ondrus, Tomas, Pavkova Goldbergova, Monika, Gal, Roman, Lokaj, Petr, Tomandlova, Marie, Parenica, Jiri

“…Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the…”
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Pulmonary hypertension - disease mechanisms by Helán, Martin, Konieczna, Anna, Klabusay, Martin, Srámek, Vladimír

“…Pulmonary hypertension (PH) is known for its variable etiology. PH pathophysiology is very complex and our therapeutic options are limited. Most of known…”
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Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle by Bartman, Colleen M., Schiliro, Marta, Helan, Martin, Prakash, Y. S., Linden, David, Pabelick, Christina

“…Preterm infants can develop airway hyperreactivity and impaired bronchodilation following supplemental O2 (hyperoxia) in early life, making it important to…”
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Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study by Tomandlova, Marie, Parenica, Jiri, Lokaj, Petr, Ondrus, Tomas, Kala, Petr, Miklikova, Marie, Helanova, Katerina, Helan, Martin, Malaska, Jan, Benesova, Klara, Jarkovsky, Jiri, Pavkova Goldbergova, Monika, Tomandl, Josef

“…Cardiogenic shock is a frequent complication of acute myocardial infarction. Similar to ischemia/reperfusion injury, excessive production of reactive oxygen…”
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Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury by Parenica, Jiri, Kala, Petr, Mebazaa, Alexandre, Littnerova, Simona, Benesova, Klara, Tomandl, Josef, Goldbergová Pavkova, Monika, Jarkovský, Jiří, Spinar, Jindrich, Tomandlova, Marie, Dastych, Milan, Ince, Can, Helanova, Katerina, Tesak, Martin, Helan, Martin, Lokaj, Petr, Legrand, Matthieu

“…Background/Aims: The pathophysiology of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients remains poorly explored. The…”
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Ischaemic Stroke Caused by a Gunshot Wound to the Chest by Helán, Martin, Ráb, Martin, Šrámek, Vladimír, Vaníček, Jiří, Staffa, Robert, Volný, Ondřej, Suk, Pavel

“…INTRODUCTIONPneumatic weapons rarely cause severe trauma. However, pellet embolisation can cause severe and unexpected injuries. REPORTThis is the case study…”
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Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle: e0129489 by Hartman, William, Helan, Martin, Smelter, Dan, Sathish, Venkatachalem, Thompson, Michael, Pabelick, Christina M, Johnson, Bruce, Prakash, Y S

“…Background Hypoxia effects on pulmonary artery structure and function are key to diseases such as pulmonary hypertension. Recent studies suggest that growth…”
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