Search Results - "Hekster, Y. A."

Pharmacokinetics of Adjusted-Dose Lopinavir-Ritonavir Combined with Rifampin in Healthy Volunteers by LA PORTE, C. J. L, COLBERS, E. P. H, BERTZ, R, VONCKEN, D. S, WIKSTROM, K, BOEREE, M. J, KOOPMANS, P. P, HEKSTER, Y. A, BURGER, D. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Pharmacokinetic Study of Tenofovir Disoproxil Fumarate Combined with Rifampin in Healthy Volunteers by DROSTE, J. A. H, VERWEIJ-VAN WISSEN, C. P. W. G. M, KEARNEY, B. P, BUFFELS, R, VANHORSSEN, P. J, HEKSTER, Y. A, BURGER, D. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Making the rheumatologist aware of patients' non-adherence does not improve medication adherence in patients with rheumatoid arthritis by van den Bemt, BJF, den Broeder, AA, van den Hoogen, FHJ, Benraad, B, Hekster, YA, van Riel, PLCM, van Lankveld, W

“…Objectives: We have developed an instrument that provides the physician structured information about medication use and patients' (non-)adherence. This study…”
Get full text

Sustained effect after lowering high-dose infliximab in patients with rheumatoid arthritis: a prospective dose titration study by van den Bemt, B J F, den Broeder, A A, Snijders, G F, Hekster, Y A, van Riel, P L C M, Benraad, B, Wolbink, G J, van den Hoogen, F H J

“…In clinical trials only a small subset of patients with rheumatoid arthritis (RA) benefits from higher than standard dose of infliximab (>3 mg/kg/8 weeks)…”
Get more information

Reappraisal of Polytherapy in Epilepsy: A Critical Review of Drug Load and Adverse Effects by Deckers, C. L. P., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O.

“…Purpose: We reviewed the literature to determine whether an analysis of published data could clarify the relationship between antiepileptic drug (AED)…”
Get full text

Principles of signal detection in pharmacovigilance by MEYBOOM, R. H. B, EGBERTS, A. C. G, EDWARDS, I. R, HEKSTER, Y. A, DE KONING, F. H. P, GRIBNAU, F. W. J

“…Adverse drug effects are manifold and heterogenous. Many situations may hamper the signalling (i.e. the detection of early warning signs) of adverse effects…”
Get full text

Application of the ATC/DDD methodology to monitor antibiotic drug use by NATSCH, S, HEKSTER, Y. A, DE JONG, R, HEERDINK, E. R, HERINGS, R. M. C, VAN DER MEER, J. W. M

“…In order to monitor the use of antibiotics, it is essential to have comprehensive data on drug consumption. The findings of drug utilisation studies can serve…”
Get full text

Ergot alkaloids : Current status and review of clinical pharmacology and therapeutic use compared with other oxytocics in obstetrics and gynaecology by DE GROOT, A. N. J. A, VAN DONGEN, P. W. J, VREE, T. B, HEKSTER, Y. A, VAN ROOSMALEN, J

“…Ergot alkaloids are well known preparations. Ergot alkaloids used in obstetrics and gynaecology are ergometrine (ergonovine; EM), methylergometrine…”
Get full text

Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed by Deckers, Charles L. P., Czuczwar, Stanislaw J., Hekster, Yechiel A., Kewser, Antoine, Kubova, Hana, Meinardi, Harry, Patsalos, Philip N., Renier, Willy O., Rijn, Clementina M.

“…Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried in an attempt to improve effectiveness by improving efficacy,…”
Get full text

Effectiveness of lamotrigine in clinical practice: Results of a retrospective population-based study by Knoester, P.D., Keyser, A., Renier, W.O., Egberts, A.C.G., Hekster, Y.A., Deckers, C.L.P.

“…Evaluation of the effectiveness of lamotrigine in a population-based cohort of epilepsy patients. Medical charts of 360 patients treated in 37 centres in The…”
Get full text

Causal or casual? The role of causality assessment in pharmacovigilance by MEYBOOM, R. H. B, HEKSTER, Y. A, EGBERTS, A. C. G, GRIBNAU, F. W. J, EDWARDS, I. R

“…As with any other study method, 'spontaneous reporting' in pharmacovigilance is a process of data acquisition, assessment, presentation and interpretation. The…”
Get full text

Selection criteria for the clinical use of the newer antiepileptic drugs by DECKERS, Charles L. P, KNOESTER, P. D, DE HAAN, G. J, KEYSER, A, RENIER, W. O, HEKSTER, Y. A

“…In recent years, several new antiepileptic drugs (AEDs) have been licensed: felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine,…”
Get full text

Carbamazepine--indinavir interaction causes antiretroviral therapy failure by Hugen, PW, Burger, DM, Brinkman, K, ter Hofstede, HJ, Schuurman, R, Koopmans, PP, Hekster, YA

“…OBJECTIVE: To report a case of antiretroviral therapy failure caused by an interaction between carbamazepine and indinavir. CASE SUMMARY: A 48-year-old…”
Get full text

Pharmacovigilance in perspective by MEYBOOM, R. H. B, EGBERTS, A. C. G, GRIBNAU, F. W. J, HEKSTER, Y. A

“…Pharmacovigilance is more than spontaneous reporting alone, and the evaluation of marketed medicines is more than just pharmacovigilance. The positioning of a…”
Get full text

Cost-effectiveness of add-on lamotrigine therapy in clinical practice by Knoester, P.D., Boendermaker, A.J., Egberts, A.C.G., Hekster, Y.A., Keyser, A., Severens, J.L., Renier, W.O., Deckers, C.L.P.

“…This retrospective study addresses the cost-effectiveness of add-on therapy with lamotrigine in clinical practice. Two years’ observational data of 165…”
Get full text

Effect of efavirenz treatment on the pharmacokinetics of nelfinavir boosted by ritonavir in healthy volunteers by La Porte, C. J. L., De Graaff‐Teulen, M. J. A., Colbers, E. P. H., Voncken, D. S., Ibanez, S. Marco, Koopmans, P. P., Hekster, Y. A., Burger, D. M.

“…Aims A once‐daily (q.d.) nucleoside‐sparing regimen can prevent mitochondrial toxicity, overcome viral resistance and improve compliance. In the present study…”
Get full text

Pharmacokinetics, food intake requirements and tolerability of once‐daily combinations of nelfinavir and low‐dose ritonavir in healthy volunteers by Aarnoutse, R. E., Droste, J. A. H., Van Oosterhout, J. J. G., Koopmans, P. P., Popescu, M., Reiss, P., Hekster, Y. A., Burger, D. M.

“…Aims This study was performed to evaluate the steady‐state pharmacokinetics, food intake requirements and short‐term tolerability of once‐daily combinations of…”
Get full text

Diffusion of the new antiepileptic drug lamotrigine in Dutch clinical practice by KNOESTER, P. D, BELITSER, S. V, DECKERS, C. L. P, KEYSER, A, RENIER, W. O, EGBERTS, A. C. G, HEKSTER, Y. A

“…Lamotrigine is one of the recently introduced antiepileptic drugs (AEDs) licensed in the Netherlands in 1995. The objective of this study was to examine the…”
Get full text

Monotherapy or polytherapy for epilepsy revisited: a quantitative assessment by Lammers, M W, Hekster, Y A, Keyser, A, Meinardi, H, Renier, W O, van Lier, H

“…Some investigators argue that treating epilepsy with several antiepileptic drugs (AEDs) simultaneously (polytherapy) may give rise to more adverse effects than…”
Get more information

Use of fluconazole in daily practice: still room for improvement by Natsch, S., Steeghs, M. H. M., Hekster, Y. A., Meis, J. F. G. M., van der Meer, J. W. M., Kullberg, B. J.

“…One hundred courses of fluconazole treatment in a university hospital and 81 courses in a non-university teaching hospital have been analysed in a prospective…”
Get full text