Search Results - "Hejnar, Jirí"

Accumulation of long-term transcriptionally active integrated retroviral vectors in active promoters and enhancers by Šenigl, Filip, Miklík, Dalibor, Auxt, Miroslav, Hejnar, Jirí

“…Most retroviruses preferentially integrate into certain genomic locations and, as a result, their genome-wide integration patterns are non-random. We…”
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Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site by Senigl, Filip, Auxt, Miroslav, Hejnar, Jirí

“…The autonomous transcription of integrated retroviruses strongly depends on genetic and epigenetic effects of the chromatin at the site of integration. These…”
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Transcriptional provirus silencing in the context of the integration site environment by Šenigl, Filip, Auxt, Miroslav, Miklík, Dalibor, Hejnar, Jiří

“…Doc number: P83…”
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Rapid adaptive evolution of avian leukosis virus subgroup J in response to biotechnologically induced host resistance by Matoušková, Magda, Plachý, Jiří, Kučerová, Dana, Pecnová, Ľubomíra, Reinišová, Markéta, Geryk, Josef, Karafiát, Vít, Hron, Tomáš, Hejnar, Jiří

“…Genetic editing of the germline using CRISPR/Cas9 technology has made it possible to alter livestock traits, including the creation of resistance to viral…”
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Jan Svoboda (1934-2017): sixty years with retroviruses by Hejnar, Jiří

“…Acknowledgements Funding was provided by Ministry of Education, Youth, and Sports (CZ) (Grant No. NPU I LO1419). Competing interests The author declares that…”
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Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds by Rohde, Franziska, Schusser, Benjamin, Hron, Tomáš, Farkašová, Helena, Plachý, Jiří, Härtle, Sonja, Hejnar, Jiří, Elleder, Daniel, Kaspers, Bernd

“…Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense and acute and chronic inflammation. It has been described in…”
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Unraveling the palindromic and nonpalindromic motifs of retroviral integration site sequences by statistical mixture models by Miklík, Dalibor, Grim, Jiří, Elleder, Daniel, Hejnar, Jiri

“…A weak palindromic nucleotide motif is the hallmark of retroviral integration site alignments. Given that the majority of target sequences are not palindromic,…”
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Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus by Koslová, Anna, Trefil, Pavel, Mucksová, Jitka, Reinišová, Markéta, Plachýa, Jiří, Kalinab, Jiří, Kučerová, Dana, Geryk, Josef, Krchlíková, Veronika, Lejčková, Barbora, Hejnar, Jiří

“…Avian leukosis virus subgroup J (ALV-J) is an important concern for the poultry industry. Replication of ALV-J depends on a functional cellular receptor, the…”
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The Novel Avian Leukosis Virus Subgroup K Shares Its Cellular Receptor with Subgroup A by Přikryl, David, Plachý, Jiří, Kučerová, Dana, Koslová, Anna, Reinišová, Markéta, Šenigl, Filip, Hejnar, Jiří

“…Avian leukosis virus subgroup K (ALV-K) is composed of newly emerging isolates, which, in sequence analyses, cluster separately from the well-characterized…”
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Long Terminal Repeats of Gammaretroviruses Retain Stable Expression after Integration Retargeting by Miklík, Dalibor, Slavková, Martina, Kučerová, Dana, Mekadim, Chahrazed, Mrázek, Jakub, Hejnar, Jiří

“…Retroviruses integrate into the genomes of infected host cells to form proviruses, a genetic platform for stable viral gene expression. Epigenetic silencing…”
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Four novel genes associated with longevity found in Cane corso purebred dogs by Korec, Evžen, Ungrová, Lenka, Hejnar, Jiří, Grieblová, Adéla

“…Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived…”
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Independent loss events of a functional tetherin gene in galliform birds by Krchlíková, Veronika, Lotke, Rishikesh, Haußmann, Isabell, Reinišová, Markéta, Kučerová, Dana, Pecnová, Ľubomíra, Ungrová, Lenka, Hejnar, Jiří, Sauter, Daniel, Elleder, Daniel

“…Birds represent important hosts for numerous viruses, including zoonotic viruses and pathogens with the potential to cause major economic losses to the poultry…”
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Genetic Diversity of NHE1, Receptor for Subgroup J Avian Leukosis Virus, in Domestic Chicken and Wild Anseriform Species by Reinišová, Markéta, Plachý, Jiří, Kučerová, Dana, Šenigl, Filip, Vinkler, Michal, Hejnar, Jiří

“…J subgroup avian leukosis virus (ALV-J) infects domestic chicken, jungle fowl, and turkey and enters the host cell through a receptor encoded by tvj locus and…”
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Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective by Krchlíková, Veronika, Hron, Tomáš, Těšický, Martin, Li, Tao, Hejnar, Jiří, Vinkler, Michal, Elleder, Daniel

“…Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals:…”
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DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas by Benešová, Martina, Trejbalová, Kateřina, Kovářová, Denisa, Vernerová, Zdenka, Hron, Tomáš, Kučerová, Dana, Hejnar, Jiří

“…Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the…”
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The Current View of Retroviruses as Seen from the Shoulders of a Giant by Hejnar, Jiří, Ruml, Tomáš

“…It has now been more than two years since we said our last goodbye to Jan Svoboda (14 [...]…”
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Genetic Resistance to Avian Leukosis Viruses Induced by CRISPR/Cas9 Editing of Specific Receptor Genes in Chicken Cells by Koslová, Anna, Kučerová, Dana, Reinišová, Markéta, Geryk, Josef, Trefil, Pavel, Hejnar, Jiří

“…Avian leukosis viruses (ALVs), which are pathogens of concern in domestic poultry, utilize specific receptor proteins for cell entry that are both necessary…”
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Dynamic Evolution of Avian RNA Virus Sensors: Repeated Loss of RIG-I and RIPLET by Krchlíková, Veronika, Hron, Tomáš, Těšický, Martin, Li, Tao, Ungrová, Lenka, Hejnar, Jiří, Vinkler, Michal, Elleder, Daniel

“…Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are key RNA virus sensors belonging to the RIG-I-like receptor…”
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Nonconserved Tryptophan 38 of the Cell Surface Receptor for Subgroup J Avian Leukosis Virus Discriminates Sensitive from Resistant Avian Species by Kucerová, Dana, Plachy, Jirí, Reinisová, Markéta, Senigl, Filip, Trejbalová, Katerina, Geryk, Josef, Hejnar, Jirí

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Proviruses with Long-Term Stable Expression Accumulate in Transcriptionally Active Chromatin Close to the Gene Regulatory Elements: Comparison of ASLV-, HIV- and MLV-Derived Vectors by Miklík, Dalibor, Šenigl, Filip, Hejnar, Jiří

“…Individual groups of retroviruses and retroviral vectors differ in their integration site preference and interaction with the host genome. Hence, immediately…”
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