In vivo effect of herbal products against Histomonas meleagridis in turkeys

Histomoniasis is a serious disease in poultry. All chemotherapeutics with known efficacy against its causative agent, Histomonas meleagridis, have been banned from use as prophylactic or therapeutic use in production animals. In a search for possible alternatives, the in vivo effects of the herbal p...

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Bibliographic Details
Published in:	Avian pathology Vol. 37; no. 1; pp. 45 - 50
Main Authors:	Hejden, H.M.J.F. van der, Landman, W.J.M
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 01-02-2008 Taylor & Francis Ltd Taylor & Francis
Subjects:	Animal diseases Animals Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Birds Dimetridazole - pharmacology Dimetridazole - therapeutic use drug therapy Effects feed additives Herbal medicine herbal medicines Histomonas meleagridis histomoniasis medicated feeds morbidity Mortality Phytotherapy - veterinary Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal poultry diseases Poultry Diseases - drug therapy Poultry Diseases - parasitology Protozoan Infections, Animal - drug therapy Protozoan Infections, Animal - parasitology Trichomonadida - drug effects turkeys Turkeys - parasitology Life Sciences
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Summary:	Histomoniasis is a serious disease in poultry. All chemotherapeutics with known efficacy against its causative agent, Histomonas meleagridis, have been banned from use as prophylactic or therapeutic use in production animals. In a search for possible alternatives, the in vivo effects of the herbal products Enteroguard™ and Protophyt™ were examined. Two-week-old turkeys allocated into 13 groups of 18 birds were either sham inoculated (negative control group) or were inoculated with 100, 3162 or 200 000 histomonads per bird. Control groups (no feed additives, dimetridazole, or Histostat-50™) were included in the study. No morbidity or mortality was observed in the negative control group or in the groups inoculated with 100 histomonads per bird. Mortality was 100% in the groups inoculated with 200 000 histomonads per bird and either untreated (positive control group) or receiving Protophyt SP™, Protophyt™ SP and Protophyt™ B, Enteroguard™, or Histostat-50™. Mortality was 17% in the dimetridazole-treated group. In the groups inoculated with 3162 histomonads per bird, mortality was 100% for the positive control group and the group receiving Enteroguard™, and was 94% in the group receiving Protophyt™ SP. In the present study, Enteroguard™ or Protophyt™ was not found to be effective against histomoniasis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0307-9457 1465-3338
DOI:	10.1080/03079450701784883