Search Results - "Heisner, James S"

Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts by Aldakkak, Mohammed, Camara, Amadou K S, Heisner, James S, Yang, Meiying, Stowe, David F

“…Ranolazine is a clinically approved drug for treating cardiac ventricular dysrhythmias and angina. Its mechanism(s) of protection is not clearly understood but…”
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Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury by Ait-Aissa, Karima, Heisner, James S, Norwood Toro, Laura E, Bruemmer, Dennis, Doyon, Genevieve, Harmann, Leanne, Geurts, Aron, Camara, Amadou K S, Beyer, Andreas M

“…Elevated levels of mitochondrial reactive oxygen species (ROS) contribute to the development of numerous cardiovascular diseases. TERT, the catalytic subunit…”
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Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia by Yang, Meiying, Stowe, David F, Udoh, Kenechukwu B, Heisner, James S, Camara, Amadou K S

“…Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66Shc, a splice variant of the ShcA adaptor…”
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Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and Its Alteration During Ischemia and Reperfusion by Ranji, Mahsa, Motlagh, Mohammad Masoudi, Salehpour, Fahimeh, Sepehr, Reyhaneh, Heisner, James S., Dash, Ranjan K., Camara, Amadou K. S.

“…Oxidation of substrates to generate ATP in mitochondria is mediated by redox reactions of NADH and FADH2. Cardiac ischemia and reperfusion (IR) injury…”
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What Doesn't Kill You Makes You Stronger—Even Heart Radiation? by SenthilKumar, Gopika, Heisner, James S., Schlaak, Rachel, Mishra, Jyotsna, Katunaric, Boran, Camara, Amadou K., Bergom, Carmen

“…Radiation therapy (RT) is a commonly used treatment for thoracic cancers. However, the risk of coronary events increase by 4‐16% per Gy of heart dose. Our…”
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Time and charge/pH-dependent activation of K + channel-mediated K + influx and K + /H + exchange in guinea pig heart isolated mitochondria; role in bioenergetic stability by Malas, Kareem M, Lambert, David S, Heisner, James S, Camara, Amadou K S, Stowe, David F

“…Mitochondria play an important role not only in producing energy for the cell but also for regulating mitochondrial and cell function depending on the cell's…”
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Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca2+ and succinate-induced oxidative stress in cardiac isolated mitochondria by Gerdes, Harrison J., Yang, Meiying, Heisner, James S., Camara, Amadou K.S., Stowe, David F.

“…We hypothesized that NO• is generated in isolated cardiac mitochondria as the source for ONOO− production during oxidative stress. We monitored generation of…”
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Low-flow Perfusion of Guinea Pig Isolated Hearts With 26°C Air-saturated Lifor Solution for 20 Hours Preserves Function and Metabolism by Stowe, David F., MD, PhD, Camara, Amadou K.S., PhD, Heisner, James S., BS, Aldakkak, Mohammed, MD, Harder, David R., PhD

“…Background Donor human hearts cannot be preserved for >5 hours between explantation and recipient implantation. A better approach is needed to preserve…”
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Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria by Yang, Meiying, Xu, Yanji, Heisner, James S, Sun, Jie, Stowe, David F, Kwok, Wai-Meng, Camara, Amadou K S

“…Cardiac ischemia and reperfusion (IR) injury induces excessive emission of deleterious reactive O and N species (ROS/RNS), including the non-radical oxidant…”
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Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts by RIESS, Matthias L, KEVIN, Leo G, CAMARA, Amadou K. S, HEISNER, James S, STOWE, David F

“…Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane…”
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Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection by Stowe, David F, Yang, Meiying, Heisner, James S, Camara, Amadou K S

“…Both big (BKCa) and small (SKCa) conductance Ca-sensitive K channels are present in mammalian cardiac cell mitochondria (m). We used pharmacological agonists…”
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Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria by Sun, Jie, Mishra, Jyotsna, Yang, Meiying, Stowe, David F., Heisner, James S., An, Jianzhong, Kwok, Wai-Meng, Camara, Amadou K. S.

“…Background. Hypothermia (H), cardioplegia (CP), and both combined (HCP) are known to be protective against myocardial ischemia reperfusion (IR) injury…”
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Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury by la Cour, Mette Funding, Mehrvar, Shima, Heisner, James S, Motlagh, Mohammad Masoudi, Medhora, Meetha, Ranji, Mahsa, Camara, Amadou K. S

“…Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether irradiation predisposes the heart to further ischemia and…”
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Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane by Stowe, David F, Gadicherla, Ashish K, Zhou, Yifan, Aldakkak, Mohammed, Cheng, Qunli, Kwok, Wai-Meng, Jiang, Ming Tao, Heisner, James S, Yang, Meiying, Camara, Amadou K S

“…We tested if small conductance, Ca(2+)-sensitive K(+) channels (SK(Ca)) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial…”
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Protection against cardiac injury by small Ca2+-sensitive K+ channels identified in guinea pig cardiac inner mitochondrial membrane by Stowe, David F., Gadicherla, Ashish K., Zhou, Yifan, Aldakkak, Mohammed, Cheng, Qunli, Kwok, Wai-Meng, Jiang, Ming Tao, Heisner, James S., Yang, MeiYing, Camara, Amadou K.S.

“…We tested if small conductance, Ca2+‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m)…”
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Targeted Cardiac Ionizing Radiation in Dahl Salt-Sensitive Rats Can Improve Recovery From Ischemic Injury by SenthilKumar, Gopika, Heisner, James S., Schlaak, Rachel, Mishra, Jyotsna, Katunaric, Boran, Pedersen, Lauren N., Lavine, Kory, Javaheri, Ali, Camara, Amadou K.S., Bergom, Carmen

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Reduced mitochondrial Ca2+ loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts by Rhodes, Samhita S, Camara, Amadou K S, Heisner, James S, Riess, Matthias L, Aldakkak, Mohammed, Stowe, David F

“…Oxidative damage and impaired cytosolic Ca(2+) concentration ([Ca(2+)](cyto)) handling are associated with mitochondrial [Ca(2+)] ([Ca(2+)](mito)) overload and…”
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Enhanced Na+/H+ Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function by Aldakkak, Mohammed, Stowe, David F, Heisner, James S, Spence, Marisha, Camara, Amadou K S

“…Inhibition of Na/H exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na/Ca exchange. We hypothesized that activating NHE-1 at…”
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ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state by Camara, Amadou K S, Aldakkak, Mohammed, Heisner, James S, Rhodes, Samhita S, Riess, Matthias L, An, JiangZhong, Heinen, André, Stowe, David F

“…We have shown that cold perfusion of hearts generates reactive oxygen and nitrogen species (ROS/RNS). In this study, we determined 1) whether ROS scavenging…”
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Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection by Aldakkak, Mohammed, Stowe, David F, Lesnefsky, Edward J, Heisner, James S, Chen, Qun, Camara, Amadou K S

“…Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and…”
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