Search Results - "Heise, Torben"

Sialic Acid Mimetics to Target the Sialic Acid–Siglec Axis by Büll, Christian, Heise, Torben, Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec)…”
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Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity by Büll, Christian, Boltje, Thomas J, Balneger, Natasja, Weischer, Sarah M, Wassink, Melissa, van Gemst, Jasper J, Bloemendal, Victor R, Boon, Louis, van der Vlag, Johan, Heise, Torben, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor…”
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Potent Metabolic Sialylation Inhibitors Based on C‑5-Modified Fluorinated Sialic Acids by Heise, Torben, Pijnenborg, Johan F. A, Büll, Christian, van Hilten, Niek, Kers-Rebel, Esther D, Balneger, Natasja, Elferink, Hidde, Adema, Gosse J, Boltje, Thomas J

“…Sialic acid sugars on mammalian cells regulate numerous biological processes, while aberrant expression of sialic acid is associated with diseases such as…”
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Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2 by van den Bijgaart, Renske J.E., Kroesen, Michiel, Wassink, Melissa, Brok, Ingrid C., Kers-Rebel, Esther D., Boon, Louis, Heise, Torben, van Scherpenzeel, Monique, Lefeber, Dirk J., Boltje, Thomas J., den Brok, Martijn H., Hoogerbrugge, Peter M., Büll, Christian, Adema, Gosse J.

“…Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is only sparsely expressed on healthy tissue. GD2…”
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Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry by Büll, Christian, Heise, Torben, van Hilten, Niek, Pijnenborg, Johan F. A., Bloemendal, Victor R. L. J., Gerrits, Lotte, Kers‐Rebel, Esther D., Ritschel, Tina, den Brok, Martijn H., Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid binding immunoglobulin‐like lectin (Siglec) family, which are…”
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Fighting Shigella by Blocking Its Disease-Causing Toxin by Haksar, Diksha, Asadpoor, Mostafa, Heise, Torben, Shi, Jie, Braber, Saskia, Folkerts, Gert, Ballell, Lluis, Rodrigues, Janneth, Pieters, Roland J

“…Shiga toxin is an AB5 toxin produced by Shigella species, while related toxins are produced by Shiga toxin-producing Escherichia coli (STEC). Infection by…”
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Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose by Xu, Yang, Wang, Xiaoqi, Zaal, Esther A., Berkers, Celia R., Lorent, Joseph H., Heise, Torben, Cox, Ruud, Pieters, Roland J., Breukink, Eefjan

“…Gram-negative bacteria possess an asymmetric outer membrane (OM) primarily composed of lipopolysaccharides (LPS) on the outer leaflet and phospholipids on the…”
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Structure-Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents by Moons, Sam J, Rossing, Emiel, Janssen, Mathilde A C H, Heise, Torben, Büll, Christian, Adema, Gosse J, Boltje, Thomas J

“…Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes, and aberrant sialic acid…”
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NANS-mediated synthesis of sialic acid is required for brain and skeletal development by van Karnebeek, Clara D M, Bonafé, Luisa, Wen, Xiao-Yan, Tarailo-Graovac, Maja, Balzano, Sara, Royer-Bertrand, Beryl, Ashikov, Angel, Garavelli, Livia, Mammi, Isabella, Turolla, Licia, Breen, Catherine, Donnai, Dian, Cormier-Daire, Valérie, Heron, Delphine, Nishimura, Gen, Uchikawa, Shinichi, Campos-Xavier, Belinda, Rossi, Antonio, Hennet, Thierry, Brand-Arzamendi, Koroboshka, Rozmus, Jacob, Harshman, Keith, Stevenson, Brian J, Girardi, Enrico, Superti-Furga, Giulio, Dewan, Tammie, Collingridge, Alissa, Halparin, Jessie, Ross, Colin J, Van Allen, Margot I, Rossi, Andrea, Engelke, Udo F, Kluijtmans, Leo A J, van der Heeft, Ed, Renkema, Herma, de Brouwer, Arjan, Huijben, Karin, Zijlstra, Fokje, Heise, Torben, Boltje, Thomas, Wasserman, Wyeth W, Rivolta, Carlo, Unger, Sheila, Lefeber, Dirk J, Wevers, Ron A, Superti-Furga, Andrea

“…Andrea Superti-Furga, Ron Wevers, Clara van Karnebeek, Luisa Bonafé and colleagues identify mutations in NANS , which encodes the sialic acid synthase, in nine…”
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Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs by van Scherpenzeel, Monique, Conte, Federica, Büll, Christian, Ashikov, Angel, Hermans, Esther, Willems, Anke, van Tol, Walinka, Kragt, Else, Noga, Marek, Moret, Ed E, Heise, Torben, Langereis, Jeroen D, Rossing, Emiel, Zimmermann, Michael, Rubio-Gozalbo, M Estela, de Jonge, Marien I, Adema, Gosse J, Zamboni, Nicola, Boltje, Thomas, Lefeber, Dirk J

“…Abstract Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate…”
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Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal α-dystroglycan O-mannosylation, independent from sialic acid by Riemersma, Moniek, Sandrock, Julia, Boltje, Thomas J, Büll, Christian, Heise, Torben, Ashikov, Angel, Adema, Gosse J, van Bokhoven, Hans, Lefeber, Dirk J

“…Binding of cellular α-dystroglycan (α-DG) to its extracellular matrix ligands is fully dependent on a unique O-mannose-linked glycan. Disrupted O-mannosylation…”
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Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation by Büll, Christian, Collado‐Camps, Estel, Kers‐Rebel, Esther D, Heise, Torben, Søndergaard, Jonas N, Brok, Martijn H, Schulte, Barbara M, Boltje, Thomas J, Adema, Gosse J

“…Sialic acid sugars cover the surface of dendritic cells (DCs) and have been suggested to impact several aspects of DC biology. Research into the role of sialic…”
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Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction by Heise, Torben, Büll, Christian, Beurskens, Daniëlle M, Rossing, Emiel, de Jonge, Marien I, Adema, Gosse J, Boltje, Thomas J, Langereis, Jeroen D

“…Metabolic incorporation of azide- or alkyne-modified sialic acids into the cellular glycosylation pathway enables the study of sialoglycan expression,…”
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Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the Detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands by Büll, Christian, Heise, Torben, Beurskens, Daniëlle M. H, Riemersma, Moniek, Ashikov, Angel, Rutjes, Floris P. J. T, van Kuppevelt, Toin H, Lefeber, Dirk J, den Brok, Martijn H, Adema, Gosse J, Boltje, Thomas J

“…Sialoglycans play a vital role in physiology, and aberrant sialoglycan expression is associated with a broad spectrum of diseases. Since biosynthesis of…”
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A Divergent Method to Prepare 5-Amino-, 5-N-Acetamido-, and 5-N-Glycolylsialosides by Boltje, Thomas J., Heise, Torben, Rutjes, Floris P. J. T., van Delft, Floris L.

“…Sialic acids are essential mediators of biological processes involving carbohydrate recognition. A major determinant of sialic acid recognition is the N‐5…”
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Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry by Büll, Christian, Heise, Torben, van Hilten, Niek, Pijnenborg, Johan F. A., Bloemendal, Victor R. L. J., Gerrits, Lotte, Kers‐Rebel, Esther D., Ritschel, Tina, den Brok, Martijn H., Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid binding immunoglobulin‐like lectin (Siglec) family, which are…”
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