Search Results - "Heinzmann, A."

Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection by Bellinghausen, Carla, Gulraiz, Fahad, Heinzmann, Alexandra C A, Dentener, Mieke A, Savelkoul, Paul H M, Wouters, Emiel F, Rohde, Gernot G, Stassen, Frank R

“…Colonization of the airways with potential pathogenic bacteria is observed in a number of chronic respiratory diseases, such as COPD or cystic fibrosis…”
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Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype by Vajen, Tanja, Benedikter, Birke J., Heinzmann, Alexandra C. A., Vasina, Elena M., Henskens, Yvonne, Parsons, Martin, Maguire, Patricia B., Stassen, Frank R., Heemskerk, Johan W. M., Schurgers, Leon J., Koenen, Rory R.

“…Extracellular vesicles (EVs) are mediators of cell communication during health and disease, and abundantly released by platelets upon activation or during…”
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Inhibition of tissue factor:factor VIIa–catalyzed factor IX and factor X activation by TFPI and TFPI constructs by Peraramelli, S., Thomassen, S., Heinzmann, A., Rosing, J., Hackeng, T. M., Hartmann, R., Scheiflinger, F., Dockal, M.

“…Summary Background TFPI is a Kunitz‐type protease inhibitor that downregulates the extrinsic coagulation pathway by inhibiting factor Xa (FXa) and FVIIa. All…”
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Fine‐mapping of IgE‐associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data by Sharma, V., Michel, S., Gaertner, V., Franke, A., Vogelberg, C., Berg, A., Bufe, A., Heinzmann, A., Laub, O., Rietschel, E., Simma, B., Frischer, T., Genuneit, J., Zeilinger, S., Illig, T., Schedel, M., Potaczek, D. P., Kabesch, M.

“…Background Genome‐wide association studies (GWAS) repeatedly identified 1q23 (FCER1A), 5q31 (RAD50‐IL13 and IL4), and 12q13 (STAT6) as major susceptibility…”
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Tissue factor‐independent inhibition of thrombin generation by tissue factor pathway inhibitor‐α by Thomassen, M. C. L. G. D., Heinzmann, A. C. A., Herfs, L., Hartmann, R., Dockal, M., Scheiflinger, F., Hackeng, T. M., Rosing, J.

“…Summary Background Tissue factor pathway inhibitor‐α (TFPIα) inhibits factor Xa by forming a binary TFPI–FXa complex in a reaction that is stimulated by…”
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Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells by Dickhout, Annemiek, Kaczor, Dawid M., Heinzmann, Alexandra C. A., Brouns, Sanne L. N., Heemskerk, Johan W. M., van Zandvoort, Marc A. M. J., Koenen, Rory R.

“…The chemokines CCL5 and CXCL4 are deposited by platelets onto endothelial cells, inducing monocyte arrest. Here, the fate of CCL5 and CXCL4 after endothelial…”
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Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact by Toncheva, A. A., Potaczek, D. P., Schedel, M., Gersting, S. W., Michel, S., Krajnov, N., Gaertner, V. D., Klingbeil, J. M., Illig, T., Franke, A., Winkler, C., Hohlfeld, J. M., Vogelberg, C., Berg, A., Bufe, A., Heinzmann, A., Laub, O., Rietschel, E., Simma, B., Genuneit, J., Muntau, A. C., Kabesch, M.

“…Background Genomewide association studies identified ORMDL3 as a plausible asthma candidate gene. ORMDL proteins regulate sphingolipid metabolism and ceramide…”
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Direct inhibition of factor VIIa by TFPI and TFPI constructs by Peraramelli, S., Thomassen, S., Heinzmann, A., Rosing, J., Hackeng, T. M., Hartmann, R., Scheiflinger, F., Dockal, M.

“…Summary Background Tissue factor pathway inhibitor (TFPI) is a multi‐Kunitz domain protease inhibitor that down‐regulates the extrinsic coagulation pathway by…”
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Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles by Benedikter, Birke J., Bouwman, Freek G., Heinzmann, Alexandra C. A., Vajen, Tanja, Mariman, Edwin C., Wouters, Emiel F. M., Savelkoul, Paul H. M., Koenen, Rory R., Rohde, Gernot G. U., van Oerle, Rene, Spronk, Henri M., Stassen, Frank R. M.

“…Airway epithelial cells secrete extracellular vesicles (EVs) under basal conditions and when exposed to cigarette smoke extract (CSE). Getting insights into…”
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Lactobacillus GG has in vitro effects on enhanced interleukin-10 and interferon-γ release of mononuclear cells but no in vivo effects in supplemented mothers and their neonates by Kopp, M. V., Goldstein, M., Dietschek, A., Sofke, J., Heinzmann, A., Urbanek, R.

“…Summary Background The value of probiotics for primary prevention is controversial. Moreover, only little is known about the underlying immunological…”
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A role of FCER1A and FCER2 polymorphisms in IgE regulation by Sharma, V., Michel, S., Gaertner, V., Franke, A., Vogelberg, C., Berg, A., Bufe, A., Heinzmann, A., Laub, O., Rietschel, E., Simma, B., Frischer, T., Genuneit, J., Potaczek, D. P., Kabesch, M.

“…Background Both FCER2 and FCER1A encode subunits of IgE receptors. Variants in FCER1A were previously identified as major determinants of IgE levels in…”
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Endocavitary contrast enhanced ultrasound (CEUS)--work in progress by Heinzmann, A, Müller, T, Leitlein, J, Braun, B, Kubicka, S, Blank, W

“…To demonstrate the benefit concerning localisation, measurement and visualisation of complications of drained fluid collections in the abdomen by applying…”
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Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions by Coenen, Daniëlle M, Heinzmann, Alexandra C A, Oggero, Silvia, Albers, Hugo J, Nagy, Magdolna, Hagué, Perrine, Kuijpers, Marijke J E, Vanderwinden, Jean-Marie, van der Meer, Andries D, Perretti, Mauro, Koenen, Rory R, Cosemans, Judith M E M

“…platelets possess not only haemostatic but also inflammatory properties, which combined are thought to play a detrimental role in thromboinflammatory diseases…”
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Genetic variants of IL-13 signalling and human asthma and atopy by HEINZMANN, A, MAO, X.-Q, ROBERTS, M. H, SUGIMOTO, R, ARIMA, K, ARINOBU, Y, YU, B, KRUSE, S, ENOMOTO, T, DAKE, Y, KAWAI, M, SHIMAZU, S, AKAIWA, M, SASAKI, S, ADRA, C. N, KITAICHI, M, INOUE, H, YAMAUCHI, K, TOMICHI, N, KURIMOTO, F, HAMASAKI, N, HOPKIN, J. M, IZUHARA, K, KREOMER, R. T, SHIRAKAWA, T, DEICHMANN, K. A, GAO, P.-S, OHSHIMA, K, UMESHITA, R, ABE, Y, BRAUN, S, YAMASHITA, T

“…Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (T(h)2) cytokine-driven inflammatory mechanisms. IL-4 operates…”
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ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels by Puthothu, B, Krueger, M, Bernhardt, M, Heinzmann, A

“…Intercellular adhesion molecule-1 (ICAM1) acts as ligand for beta2-integrin molecules and mediates leucocyte trafficking to the site of inflammation…”
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Polymorphisms in the IRF-4 gene, asthma and recurrent bronchitis in children by Pinto, L. A., Michel, S., Klopp, N., Vogelberg, C., von Berg, A., Bufe, A., Heinzmann, A., Laub, O., Simma, B., Frischer, T., Genuneit, J., Gorski, M., Illig, T., Kabesch, M.

“…Summary Background Interferon‐regulatory factors (IRFs) play a crucial role in immunity, not only influencing interferon expression but also T cell…”
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WS23.3 ICM is sensitive to detect potentiation of CFTR-mediated Cl− secretion in patients with cystic fibrosis and the G551D mutation treated with ivacaftor by Graeber, S.Y, Hug, M.J, Sommerburg, O, Mainz, J.G, Heinzmann, A, Tümmler, B, Mall, M.A

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Is toll‐like receptor 6 or toll‐like receptor 10 involved in asthma genetics – or both? by Puthothu, B., Heinzmann, A.

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Polymorphisms of interleukin 18 in the genetics of preterm birth and bronchopulmonary dysplasia by Krueger, M, Heinzmann, A, Mailaparambil, B, Härtel, C, Göpel, W

“…Interleukin 18 (IL-18) is an important cytokine and involved in the pathogenesis and genetics of many diseases. The authors studied two different populations…”
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Detection of an iliacoenteric fistula as a rare cause of lower gastrointestinal bleeding by contrast-enhanced ultrasound (CEUS) by Nonnenmacher, S, Müller, T, Haug, U, Blank, W, Kubicka, S, Heinzmann, A

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