Search Results - "Heinzl, Geoffrey"

Differentiating the Effects of Oxidative Stress Tests on Biopharmaceuticals by Heinzl, Geoffrey A., Lai, Lo, Rao, V. Ashutosh

“…Purpose A rapid and broadly applicable method to assess relevant oxidative damage in biopharmaceuticals is important for lifecycle management of product…”
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Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa by Heinzl, Geoffrey A, Huang, Weiliang, Yu, Wenbo, Giardina, Bennett J, Zhou, Yue, MacKerell, Alexander D, Wilks, Angela, Xue, Fengtian

“…New therapeutic targets are required to combat multidrug resistant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due…”
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The Asp99–Arg188 salt bridge of the Pseudomonas aeruginosa HemO is critical in allowing conformational flexibility during catalysis by Heinzl, Geoffrey A., Huang, Weiliang, Robinson, Elizabeth, Xue, Fengtian, Möenne-Loccoz, Pierre, Wilks, Angela

“…The P. aeruginosa iron-regulated heme oxygenase (HemO) is required within the host for the utilization of heme as an iron source. As iron is essential for…”
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Correction to: The Asp99–Arg188 salt bridge of the Pseudomonas aeruginosa HemO is critical in allowing conformational flexibility during catalysis by Heinzl, Geoffrey A., Huang, Weiliang, Robinson, Elizabeth, Xue, Fengtian, Möene-Loccoz, Pierre, Wilks, Angela

“…In the original publication, fifth author’s name was incorrectly published as Pierre Moenne-Loccoz…”
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Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of P. aeruginosa by Hom, Kellie, Heinzl, Geoffrey A, Eakanunkul, Suntara, Lopes, Pedro E. M, Xue, Fengtian, MacKerell, Alexander D, Wilks, Angela

“…Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in…”
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Heme oxygenation and the widening paradigm of heme degradation by Wilks, Angela, Heinzl, Geoffrey

“…•Heme oxygenases utilize heme as both a substrate and cofactor.•The activation of O2 to the ferric hydroperoxide intermediate leads to heme hydroxylation.•Heme…”
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Base-catalyzed one-step synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines by He, Xinhua, Kassab, Shaymaa E., Heinzl, Geoffrey, Xue, Fengtian

“…[Display omitted] We report a practical high-yield synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines using a base-assisted cyclocondensation of…”
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Room temperature catalyst-free Knoevenagel condensation: facile access to isatinylidenerhodanines by Xue, Fengtian, MacKerell, Alexander D., Heinzl, Geoffrey, Hom, Kellie

“…A catalyst-free Knoevenagel type synthesis of isatinylidenerhodanines is reported starting from substituted isatins and rhodanines. The reaction proceeds…”
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Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling by Jung, Kwan-Young, Samadani, Ramin, Chauhan, Jay, Nevels, Kerrick, Yap, Jeremy L, Zhang, Jun, Worlikar, Shilpa, Lanning, Maryanna E, Chen, Lijia, Ensey, Mary, Shukla, Sagar, Salmo, Rosene, Heinzl, Geoffrey, Gordon, Caryn, Dukes, Troy, MacKerell, Jr, Alexander D, Shapiro, Paul, Fletcher, Steven

“…We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione,…”
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Inhibiting the Iron-regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa via Competitive and Non-competitive Mechanisms by Heinzl, Geoffrey Addison

“…The discovery and development of new antimicrobials has become a top priority as resistance to known therapeutics continues to grow. While most antimicrobials…”
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