Search Results - "Heinz, Leonhard X."

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses by Köberlin, Marielle S., Snijder, Berend, Heinz, Leonhard X., Baumann, Christoph L., Fauster, Astrid, Vladimer, Gregory I., Gavin, Anne-Claude, Superti-Furga, Giulio

“…Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory…”
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Crystal structure of mammalian acid sphingomyelinase by Gorelik, Alexei, Illes, Katalin, Heinz, Leonhard X., Superti-Furga, Giulio, Nagar, Bhushan

“…Acid sphingomyelinase (ASMase, ASM, SMPD1 ) converts sphingomyelin into ceramide, modulating membrane properties and signal transduction. Inactivating…”
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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 by Heinz, Leonhard X., Lee, JangEun, Kapoor, Utkarsh, Kartnig, Felix, Sedlyarov, Vitaly, Papakostas, Konstantinos, César-Razquin, Adrian, Essletzbichler, Patrick, Goldmann, Ulrich, Stefanovic, Adrijana, Bigenzahn, Johannes W., Scorzoni, Stefania, Pizzagalli, Mattia D., Bensimon, Ariel, Müller, André C., King, F. James, Li, Jun, Girardi, Enrico, Mbow, M. Lamine, Whitehurst, Charles E., Rebsamen, Manuele, Superti-Furga, Giulio

“…Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses 1 – 3 . Here we show that a previously…”
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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1 by Groß, Olaf, Yazdi, Amir S., Thomas, Christina J., Masin, Mark, Heinz, Leonhard X., Guarda, Greta, Quadroni, Manfredo, Drexler, Stefan K., Tschopp, Jurg

“…Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β), inflammasomes occupy a central role in the inflammatory response…”
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LZTR1 is a regulator of RAS ubiquitination and signaling by Bigenzahn, Johannes W, Collu, Giovanna M, Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I, Heinz, Leonhard X, Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A, Müller, André C, Winter, Georg E, Kralovics, Robert, Brummelkamp, Thijn R, Mlodzik, Marek, Superti-Furga, Giulio

“…In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding…”
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Functional crosstalk between membrane lipids and TLR biology by Köberlin, Marielle S, Heinz, Leonhard X, Superti-Furga, Giulio

“…Highlights • Membrane lipid metabolism and TLR signaling are highly connected processes. • Cytokine release is altered in lysosomal lipid storage disorders in…”
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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification by Sedlyarov, Vitaly, Eichner, Ruth, Girardi, Enrico, Essletzbichler, Patrick, Goldmann, Ulrich, Nunes-Hasler, Paula, Srndic, Ismet, Moskovskich, Anna, Heinz, Leonhard X., Kartnig, Felix, Bigenzahn, Johannes W., Rebsamen, Manuele, Kovarik, Pavel, Demaurex, Nicolas, Superti-Furga, Giulio

“…Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we…”
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A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity by Boeszoermenyi, Andras, Bernaleau, Léa, Chen, Xudong, Kartnig, Felix, Xie, Min, Zhang, Haobo, Zhang, Sensen, Delacrétaz, Maeva, Koren, Anna, Hopp, Ann-Katrin, Dvorak, Vojtech, Kubicek, Stefan, Aletaha, Daniel, Yang, Maojun, Rebsamen, Manuele, Heinz, Leonhard X., Superti-Furga, Giulio

“…Dysregulation of pathogen-recognition pathways of the innate immune system is associated with multiple autoimmune disorders. Due to the intricacies of the…”
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Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking by Fauster, Astrid, Rebsamen, Manuele, Willmann, Katharina L., César-Razquin, Adrian, Girardi, Enrico, Bigenzahn, Johannes W., Schischlik, Fiorella, Scorzoni, Stefania, Bruckner, Manuela, Konecka, Justyna, Hörmann, Katrin, Heinz, Leonhard X., Boztug, Kaan, Superti-Furga, Giulio

“…Regulation of cell and tissue homeostasis by programmed cell death is a fundamental process with wide physiological and pathological implications. The advent…”
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The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity by Heinz, Leonhard X., Baumann, Christoph L., Köberlin, Marielle S., Snijder, Berend, Gawish, Riem, Shui, Guanghou, Sharif, Omar, Aspalter, Irene M., Müller, André C., Kandasamy, Richard K., Breitwieser, Florian P., Pichlmair, Andreas, Bruckner, Manuela, Rebsamen, Manuele, Blüml, Stephan, Karonitsch, Thomas, Fauster, Astrid, Colinge, Jacques, Bennett, Keiryn L., Knapp, Sylvia, Wenk, Markus R., Superti-Furga, Giulio

“…Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular…”
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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration by Krishnaswamy, Jayendra Kumar, Singh, Arpita, Gowthaman, Uthaman, Wu, Renee, Gorrepati, Pavane, Nascimento, Manuela Sales, Gallman, Antonia, Liu, Dong, Rhebergen, Anne Marie, Calabro, Samuele, Xu, Lan, Ranney, Patricia, Srivastava, Anuj, Ranson, Matthew, Gorham, James D., McCaw, Zachary, Kleeberger, Steven R., Heinz, Leonhard X., Müller, André C., Bennett, Keiryn L., Superti-Furga, Giulio, Henao-Mejia, Jorge, Sutterwala, Fayyaz S., Williams, Adam, Flavell, Richard A., Eisenbarth, Stephanie C.

“…Significance Understanding dendritic cell (DC) migration during an immune response is fundamental to defining the rules that govern T cell-mediated immunity…”
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A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations by Hörmann, Katrin, Stukalov, Alexey, Müller, André C, Heinz, Leonhard X, Superti-Furga, Giulio, Colinge, Jacques, Bennett, Keiryn L

“…Plasma membrane (PM) proteins contribute to the identity of a cell, mediate contact and communication, and account for more than two-thirds of known drug…”
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The accelerated waning of immunity and reduced effect of booster in patients treated with bDMARD and tsDMARD after SARS-CoV-2 mRNA vaccination by Tobudic, Selma, Simader, Elisabeth, Deimel, Thomas, Straub, Jennifer, Kartnig, Felix, Heinz, Leonhard X, Mandl, Peter, Haslacher, Helmuth, Perkmann, Thomas, Schneider, Lisa, Nothnagl, Thomas, Radner, Helga, Winkler, Florian, Burgmann, Heinz, Stiasny, Karin, Novacek, Gottfried, Reinisch, Walter, Aletaha, Daniel, Winkler, Stefan, Blüml, Stephan

“…This study aimed to assess the duration of humoral responses after two doses of SARS-CoV-2 mRNA vaccines in patients with inflammatory joint diseases and IBD…”
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Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story by Bonelli, Michael, Kerschbaumer, Andreas, Kastrati, Kastriot, Ghoreschi, Kamran, Gadina, Massimo, Heinz, Leonhard X, Smolen, Josef S, Aletaha, Daniel, O'Shea, John, Laurence, Arian

“…Fundamental insight gained over the last decades led to the discovery of cytokines as pivotal drivers of inflammatory diseases such as rheumatoid arthritis,…”
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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 by Rebsamen, Manuele, Pochini, Lorena, Stasyk, Taras, de Araújo, Mariana E. G., Galluccio, Michele, Kandasamy, Richard K., Snijder, Berend, Fauster, Astrid, Rudashevskaya, Elena L., Bruckner, Manuela, Scorzoni, Stefania, Filipek, Przemyslaw A., Huber, Kilian V. M., Bigenzahn, Johannes W., Heinz, Leonhard X., Kraft, Claudine, Bennett, Keiryn L., Indiveri, Cesare, Huber, Lukas A., Superti-Furga, Giulio

“…The mTORC1 protein kinase complex integrates nutrient and growth stimuli to modulate signalling pathways that regulate cellular metabolism and physiology, but…”
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Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomised controlled trial by Bonelli, Michael, Mrak, Daniel, Tobudic, Selma, Sieghart, Daniela, Koblischke, Maximilian, Mandl, Peter, Kornek, Barbara, Simader, Elisabeth, Radner, Helga, Perkmann, Thomas, Haslacher, Helmuth, Mayer, Margareta, Hofer, Philipp, Redlich, Kurt, Husar-Memmer, Emma, Fritsch-Stork, Ruth, Thalhammer, Renate, Stiasny, Karin, Winkler, Stefan, Smolen, Josef S, Aberle, Judith H, Zeitlinger, Markus, Heinz, Leonhard X, Aletaha, Daniel

“…SARS-CoV-2-induced COVID-19 has led to exponentially rising mortality, particularly in immunosuppressed patients, who inadequately respond to conventional…”
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Differential involvement of PU.1 and Id2 downstream of TGF-β1 during Langerhans-cell commitment by Heinz, Leonhard X., Platzer, Barbara, Reisner, Peter M., Jörgl, Almut, Taschner, Sabine, Göbel, Florian, Strobl, Herbert

“…Langerhans cells (LCs) are highly abundant dendritic cells (DCs) in epidermal and mucosal tissues. The transcription factors PU.1 and Id2 have been implicated…”
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Immunogenicity and safety of a fourth COVID-19 vaccination in rituximab-treated patients: an open-label extension study by Mrak, Daniel, Simader, Elisabeth, Sieghart, Daniela, Mandl, Peter, Radner, Helga, Perkmann, Thomas, Haslacher, Helmuth, Mayer, Margareta, Koblischke, Maximilian, Hofer, Philipp, Göschl, Lisa, Kartnig, Felix, Deimel, Thomas, Kerschbaumer, Andreas, Hummel, Thomas, Kornek, Barbara, Thalhammer, Renate, Stiasny, Karin, Winkler, Stefan, Smolen, Josef S, Aberle, Judith H, Aletaha, Daniel, Heinz, Leonhard X, Bonelli, Michael

“…Patients under rituximab therapy are at high risk for a severe COVID-19 disease course. Humoral immune responses to SARS-CoV-2 vaccination are vastly…”
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Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity by Gorelik, Alexei, Heinz, Leonhard X., Illes, Katalin, Superti-Furga, Giulio, Nagar, Bhushan

“…The enzyme acid sphingomyelinase-like phosphodiesterase 3B (SMPDL3B) was shown to act as a negative regulator of innate immune signaling, affecting cellular…”
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TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation by Suto, Takahito, Tosevska, Anela, Dalwigk, Karolina, Kugler, Maximillian, Dellinger, Mirjam, Stanic, Irena, Platzer, Alexander, Niederreiter, Birgit, Sevelda, Florian, Bonelli, Michael, Pap, Thomas, Kiener, Hans, Okamura, Koichi, Chikuda, Hirotaka, Aletaha, Daniel, Heinz, Leonhard X, Karonitsch, Thomas

“…TNF-induced activation of fibroblast-like synoviocytes (FLS) is a critical determinant for synovial inflammation and joint destruction in rheumatoid arthritis…”
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