Search Results - "Heintz, Nathaniel"

Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain by Kriaucionis, Skirmantas, Heintz, Nathaniel

“…Despite the importance of epigenetic regulation in neurological disorders, little is known about neuronal chromatin. Cerebellar Purkinje neurons have large and…”
Get full text

5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes by Mellén, Marian, Ayata, Pinar, Heintz, Nathaniel

“…5-hydroxymethylcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its accumulation is cell-specific and correlated with gene expression…”
Get full text

GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits by Gerfen, Charles R., Paletzki, Ronald, Heintz, Nathaniel

“…Recent development of molecular genetic techniques are rapidly advancing understanding of the functional role of brain circuits in behavior. Critical to this…”
Get full text

Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP) by Heiman, Myriam, Kulicke, Ruth, Fenster, Robert J, Greengard, Paul, Heintz, Nathaniel

“…Translating ribosome affinity purification (TRAP) combines cell type–specific transgene expression with affinity purification of translating ribosomes and can…”
Get full text

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors by Li, Kun, Nakajima, Miho, Ibañez-Tallon, Ines, Heintz, Nathaniel

“…The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor…”
Get full text

Cell-Type-Specific Contributions of Medial Prefrontal Neurons to Flexible Behaviors by Nakayama, Hirofumi, Ibañez-Tallon, Ines, Heintz, Nathaniel

“…Behavioral flexibility and impulse control are necessary for successful execution of adaptive behavior. They are impaired in patients with damage to the…”
Get full text

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex by Morishita, Hirofumi, Miwa, Julie M, Heintz, Nathaniel, Hensch, Takao K

“…Experience-dependent brain plasticity typically declines after an early critical period during which circuits are established. Loss of plasticity with closure…”
Get full text

Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit by Anthony, Todd E., Dee, Nick, Bernard, Amy, Lerchner, Walter, Heintz, Nathaniel, Anderson, David J.

“…The extended amygdala has dominated research on the neural circuitry of fear and anxiety, but the septohippocampal axis also plays an important role. The…”
Get full text

Bac to the future: The use of bac transgenic mice for neuroscience research by Heintz, Nathaniel

“…The development of methods for engineering bacterial artificial chromosomes (BACs), and for the efficient production of BAC transgenic mice, has allowed the…”
Get full text

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System by Mellén, Marian, Ayata, Pinar, Dewell, Scott, Kriaucionis, Skirmantas, Heintz, Nathaniel

“…The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those…”
Get full text

Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells by Dougherty, Joseph D, Schmidt, Eric F, Nakajima, Miho, Heintz, Nathaniel

“…We have recently developed a novel method for the affinity purification of the complete suite of translating mRNA from genetically labeled cell populations…”
Get full text

Local production of corticotropin-releasing hormone in prefrontal cortex modulates male-specific novelty exploration by Riad, Michael H, Park, Kwanghoon, Ibañez-Tallon, Ines, Heintz, Nathaniel

“…Neuromodulatory substances can be released from distal afferents for communication between brain structures or produced locally to modulate neighboring circuit…”
Get full text

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons by Li, Lishi, Rutlin, Michael, Abraira, Victoria E., Cassidy, Colleen, Kus, Laura, Gong, Shiaoching, Jankowski, Michael P., Luo, Wenqin, Heintz, Nathaniel, Koerber, H. Richard, Woodbury, C. Jeffery, Ginty, David D.

“…Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and…”
Get full text

Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors by Shrestha, Prerana, Mousa, Awni, Heintz, Nathaniel

“…Major depressive disorder (MDD) is a prevalent illness that can be precipitated by acute or chronic stress. Studies of patients with Wolfram syndrome and…”
Get full text

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn by Abraira, Victoria E., Kuehn, Emily D., Chirila, Anda M., Springel, Mark W., Toliver, Alexis A., Zimmerman, Amanda L., Orefice, Lauren L., Boyle, Kieran A., Bai, Ling, Song, Bryan J., Bashista, Karleena A., O'Neill, Thomas G., Zhuo, Justin, Tsan, Connie, Hoynoski, Jessica, Rutlin, Michael, Kus, Laura, Niederkofler, Vera, Watanabe, Masahiko, Dymecki, Susan M., Nelson, Sacha B., Heintz, Nathaniel, Hughes, David I., Ginty, David D.

“…The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array…”
Get full text

Serotonin receptor 4 in the hippocampus modulates mood and anxiety by Karayol, Remzi, Medrihan, Lucian, Warner-Schmidt, Jennifer L., Fait, Ben W., Rao, Meghana N., Holzner, Eva B., Greengard, Paul, Heintz, Nathaniel, Schmidt, Eric F.

“…Serotonin receptor 4 (5-HT 4 R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting…”
Get full text

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types by Heiman, Myriam, Schaefer, Anne, Gong, Shiaoching, Peterson, Jayms D., Day, Michelle, Ramsey, Keri E., Suárez-Fariñas, Mayte, Schwarz, Cordelia, Stephan, Dietrich A., Surmeier, D. James, Greengard, Paul, Heintz, Nathaniel

“…The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using bacterial artificial…”
Get full text

Species and cell-type properties of classically defined human and rodent neurons and glia by Xu, Xiao, Stoyanova, Elitsa I, Lemiesz, Agata E, Xing, Jie, Mash, Deborah C, Heintz, Nathaniel

“…Determination of the molecular properties of genetically targeted cell types has led to fundamental insights into mouse brain function and dysfunction. Here,…”
Get full text

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
Get full text

Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus by Mulvey, Bernard, Bhatti, Dionnet L., Gyawali, Sandeep, Lake, Allison M., Kriaucionis, Skirmantas, Ford, Christopher P., Bruchas, Michael R., Heintz, Nathaniel, Dougherty, Joseph D.

“…Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders…”
Get full text