Search Results - "Heinrikson, R. L"

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity by Yan, Riqiang, Gurney, Mark E, Bienkowski, Michael J, Shuck, Mary E, Miao, Huiyi, Tory, Monica C, Pauley, Adele M, Brashler, John R, Stratman, Nancy C, Mathews, W. Rodney, Buhl, Allen E, Carter, Donald B, Tomasselli, Alfredo G, Parodi, Luis A, Heinrikson, Robert L

“…Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases,…”
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Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease by ROHER, A. E, LOWENSON, J. D, GREENBERG, B. D, CLARKE, S, WOLKOW, C, RONG WANG, COTTER, R. J, REARDON, I. M, ZÜRCHER-NEELY, H. A, HEINRIKSON, R. L, BALL, M. J

“…The structure of beta-amyloid (beta A) from Alzheimer disease brains was examined to determine if post-translational modifications might be linked to the…”
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High yield expression of human BACE constructs in Eschericia coli for refolding, purification, and high resolution diffracting crystal forms by Tomasselli, A G, Paddock, D J, Emmons, T L, Mildner, A M, Leone, J W, Lull, J M, Cialdella, J I, Prince, D B, Fischer, H D, Heinrikson, R L, Benson, T E

“…BACE (beta-site APP cleaving enzyme) or beta-secretase, the enzyme responsible for processing APP to give the N-terminal portion of the Abeta peptide, is a…”
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Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase by Wilborn, T W, Comer, K A, Dooley, T P, Reardon, I M, Heinrikson, R L, Falany, C N

“…A cDNA encoding the human liver phenol-sulfating form of phenol sulfotransferase (P-PST) has been isolated and characterized from a lambda Uni-Zap XR human…”
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Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide by Zhang, Z Y, Poorman, R A, Maggiora, L L, Heinrikson, R L, Kézdy, F J

“…Human immunodeficiency virus 1 (HIV-1) protease is an aspartyl protease composed of two identical protomers linked by a four-stranded antiparallel beta-sheet…”
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Nucleotide sequence and expression of the capsid protein gene of feline calicivirus by Neill, J.D. (Pioneer Hi-Bred International, Inc., Johnston, IA), Reardon, I.M, Heinrikson, R.L

“…The sequence of the 3'-terminal 2,486 bases of the feline calicivirus (FCV) genome was determined. This region of the FCV genome, from which the 2.4-kb…”
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Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction by Emmons, T L, Shuck, M E, Babcock, M S, Holloway, J S, Leone, J W, Durbin, J D, Paddock, D J, Prince, D B, Heinrikson, R L, Fischer, H D, Bienkowski, M J, Benson, T E, Tomasselli, A G

“…BACE, or beta-secretase, is an attractive target in the treatment of Alzheimer's Disease because of its involvement in the generation of amyloid beta peptides…”
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A cumulative specificity model for proteases from human immunodeficiency virus types 1 and 2, inferred from statistical analysis of an extended substrate data base by POORMAN, R. A, TOMASSELLI, A. G, HEINRIKSON, R. L, KEZDY, F. J

“…Statistical analysis of an expanded data base of regions in viral polyproteins and in non-viral proteins that are sensitive to hydrolysis by the protease from…”
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A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation by McQuade, T. J., Tomasselli, A. G., Liu, L., Karacostas, V., Moss, B., Sawyer, T. K., Heinrikson, R. L., Tarpley, W. G.

“…A synthetic peptidemimetic substrate of the human immunodeficiency virus 1 (HIV-1) protease with a nonhydrolyzable pseudodipeptidyl insert at the protease…”
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The lysine-49 phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. Relation of structure and function to other phospholipases A2 by Maraganore, J M, Heinrikson, R L

“…A new class of phospholipases A2 that have a lysine at position 49 differ from the more conventional Asp-49 enzymes with respect to the sequential binding of…”
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Mechanism, Structure-Activity Studies, and Potential Applications of Glutathione S-Transferase-Catalyzed Cleavage of Sulfonamides by ZHIYANG ZHAO, KOEPLINGER, K. A, PETERSON, T, CONRADI, R. A, BURTON, P. S, SUARATO, A, HEINRIKSON, R. L, TOMASSELLI, A. G

“…The mechanism of sulfonamide cleavage of PNU-109112, a potent HIV-1 protease inhibitor, by glutathione- S -transferase (GST) was investigated in the presence…”
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The crystal structure of a lysine 49 phospholipase A2 from the venom of the cottonmouth snake at 2.0-A resolution by Holland, D R, Clancy, L L, Muchmore, S W, Ryde, T J, Einspahr, H M, Finzel, B C, Heinrikson, R L, Watenpaugh, K D

“…The crystal structure of a lysine 49 variant phospholipase A2 (K49 PLA2) has been determined at 2.0-A resolution. This particular phospholipase A2, purified…”
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A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding by Maraganore, J M, Merutka, G, Cho, W, Welches, W, Kézdy, F J, Heinrikson, R L

“…We report here the discovery of a new class of phospholipases A2 in which Asp-49, a residue considered to be an obligate component of the catalytic apparatus,…”
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The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13 by A W Yem, A G Tomasselli, R L Heinrikson, H Zurcher-Neely, V A Ruff, R A Johnson, M R Deibel, Jr

“…Extracts from human Jurkat cells or from calf thymus contain a 60-kDa protein that is bound to immobilized FK506. As expected, the NH2-terminal sequences of…”
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Activated Sulfonamides are Cleaved by Glutathione-S-Transferases by KOEPLINGER, K. A, ZHIYANG ZHAO, PETERSON, T, LEONE, J. W, SCHWENDE, F. S, HEINRIKSON, R. L, TOMASSELLI, A. G

“…In preclinical pharmacokinetic studies and in in vitro rat, dog, and human primary hepatocyte incubations, the sulfonamide (-NH-SO 2 -) bond of a potent…”
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The chemical basis for interfacial activation of monomeric phospholipases A2. Autocatalytic derivatization of the enzyme by acyl transfer from substrate by Cho, W, Tomasselli, A G, Heinrikson, R L, Kézdy, F J

“…A basic monomeric phospholipase A2 from the venom of the American water moccasin, Agkistrodon piscivorus piscivorus, undergoes Ca2+-dependent, autocatalytic…”
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Heterodimer formation is essential for heparanase enzymatic activity by Levy-Adam, Flonia, Miao, Hua-Quan, Heinrikson, Robert L, Vlodavsky, Israel, Ilan, Neta

“…Heparanase is an endo-β- d-glucuronidase involved in cleavage of heparan sulfate residues and hence participates in extracellular matrix degradation and…”
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Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus by TOMASSELLI, A. G, HUI, J. O, ADAMS, L, CHOSAY, J, LOWERY, D, GREENBERG, B, YEM, A, DEIBEL, M. R, ZÜRCHER-NEELY, H, HEINRIKSON, R. L

“…We show here for the first time that actin, troponin C, Alzheimer amyloid precursor protein (AAP), and pro-interleukin 1 beta (pro-IL-1 beta), are substrates…”
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Dissection and sequence analysis of phospholipases A2 by Heinrikson, R L

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The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors by MULICHAK, A. M, HUI, J. O, TOMASSELLI, A. G, HEINRIKSON, R. L, CURRY, K. A, CHE-SHEN TOMICH, SUVIT THAISRIVONGS, SAWYER, T. K, WATENPAUGH, K. D

“…The crystal structure of human immunodeficiency virus (HIV) type 2 protease has been determined in complexes with peptidic inhibitors Noa-His-Cha psi…”
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